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Microbial transformation of quercetin and its prenylated derivatives.
Nat Prod Res. 2018 Apr; 32(8):902-908.NP

Abstract

The microbial transformation studies of 7-O-prenylquercetin (1), 4'-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these flavonoids. Structures of the three new (4-6) and one known (7) metabolites were elucidated as 7-O-prenylquercetin 3-O-β-D-glucopyranoside (4), 4'-O-prenylquercetin 3-O-β-D-glucopyranoside (5), 4'-O-prenylquercetin 3'-O-β-D-glucopyranoside (6) and quercetin 5-O-β-D-glucopyranoside (7) by the spectroscopic methods.

Authors+Show Affiliations

a College of Pharmacy and Research Institute of Drug Development , Chonnam National University , Gwangju , Republic of Korea.a College of Pharmacy and Research Institute of Drug Development , Chonnam National University , Gwangju , Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28826260

Citation

Xiao, Yina, and Ik-Soo Lee. "Microbial Transformation of Quercetin and Its Prenylated Derivatives." Natural Product Research, vol. 32, no. 8, 2018, pp. 902-908.
Xiao Y, Lee IS. Microbial transformation of quercetin and its prenylated derivatives. Nat Prod Res. 2018;32(8):902-908.
Xiao, Y., & Lee, I. S. (2018). Microbial transformation of quercetin and its prenylated derivatives. Natural Product Research, 32(8), 902-908. https://doi.org/10.1080/14786419.2017.1367780
Xiao Y, Lee IS. Microbial Transformation of Quercetin and Its Prenylated Derivatives. Nat Prod Res. 2018;32(8):902-908. PubMed PMID: 28826260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial transformation of quercetin and its prenylated derivatives. AU - Xiao,Yina, AU - Lee,Ik-Soo, Y1 - 2017/08/22/ PY - 2017/8/23/pubmed PY - 2018/4/18/medline PY - 2017/8/23/entrez KW - Microbial transformation KW - glucosylation KW - prenylated quercetin SP - 902 EP - 908 JF - Natural product research JO - Nat. Prod. Res. VL - 32 IS - 8 N2 - The microbial transformation studies of 7-O-prenylquercetin (1), 4'-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these flavonoids. Structures of the three new (4-6) and one known (7) metabolites were elucidated as 7-O-prenylquercetin 3-O-β-D-glucopyranoside (4), 4'-O-prenylquercetin 3-O-β-D-glucopyranoside (5), 4'-O-prenylquercetin 3'-O-β-D-glucopyranoside (6) and quercetin 5-O-β-D-glucopyranoside (7) by the spectroscopic methods. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/28826260/Microbial_transformation_of_quercetin_and_its_prenylated_derivatives_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2017.1367780 DB - PRIME DP - Unbound Medicine ER -
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