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A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects.
J Neuroradiol. 2018 Feb; 45(1):23-31.JN

Abstract

PURPOSE

Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls.

MATERIAL AND METHODS

Twenty-nine morphological measurements were taken on 302 mid-sagittal MR images of adult female CMI patients (n=162) and healthy controls (n=140). All MR images were voluntarily provided by CMI subjects through an online database and control participant images were obtained through the Human Connectome Project and a local hospital system.

RESULTS

Analyses were performed on the full dataset of adult female MR images and a restricted dataset of 229 participants that were equated for age, race, and body mass index. Eighteen group differences were identified in the PCF area that we grouped into three clusters; PCF structures heights, clivus angulation, and odontoid process irregularity. Fourteen group differences persisted after equating our CMI and control groups on demographic characteristics.

CONCLUSION

PCF structures reliably differ in adult female CMI patients relative to healthy controls. These differences reflect structural abnormalities in the osseous and soft tissue structures of the clivus, odontoid process, and cerebellum. Clinical and pathophysiological implications are discussed.

Authors+Show Affiliations

Department of Psychology, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA.Department of Biomedical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA.Department of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA.Department of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA.Department of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27703, USA.Department of Biological Engineering, University of Idaho, Moscow, ID, 83844, USA.Department of Radiology, Division of Neuroradiology, University of Michigan Health System, Ann Arbor, MI, 48103, USA.Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, 21218, USA.Department of Psychology, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA.Department of Biomedical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA; Department of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, Akron, OH, 44325, USA. Electronic address: Loth@uakron.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28826656

Citation

Houston, James R., et al. "A Morphometric Assessment of Type I Chiari Malformation Above the McRae Line: a Retrospective Case-control Study in 302 Adult Female Subjects." Journal of Neuroradiology = Journal De Neuroradiologie, vol. 45, no. 1, 2018, pp. 23-31.
Houston JR, Eppelheimer MS, Pahlavian SH, et al. A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects. J Neuroradiol. 2018;45(1):23-31.
Houston, J. R., Eppelheimer, M. S., Pahlavian, S. H., Biswas, D., Urbizu, A., Martin, B. A., Bapuraj, J. R., Luciano, M., Allen, P. A., & Loth, F. (2018). A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects. Journal of Neuroradiology = Journal De Neuroradiologie, 45(1), 23-31. https://doi.org/10.1016/j.neurad.2017.06.006
Houston JR, et al. A Morphometric Assessment of Type I Chiari Malformation Above the McRae Line: a Retrospective Case-control Study in 302 Adult Female Subjects. J Neuroradiol. 2018;45(1):23-31. PubMed PMID: 28826656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects. AU - Houston,James R, AU - Eppelheimer,Maggie S, AU - Pahlavian,Soroush Heidari, AU - Biswas,Dipankar, AU - Urbizu,Aintzane, AU - Martin,Bryn A, AU - Bapuraj,Jayapalli Rajiv, AU - Luciano,Mark, AU - Allen,Philip A, AU - Loth,Francis, Y1 - 2017/08/18/ PY - 2017/01/26/received PY - 2017/06/23/revised PY - 2017/06/30/accepted PY - 2017/8/23/pubmed PY - 2018/7/22/medline PY - 2017/8/23/entrez KW - Chiari I malformation KW - Cranio-vertebral junction KW - MRI KW - Morphometry KW - Odontoid KW - Posterior cranial fossa SP - 23 EP - 31 JF - Journal of neuroradiology = Journal de neuroradiologie JO - J Neuroradiol VL - 45 IS - 1 N2 - PURPOSE: Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls. MATERIAL AND METHODS: Twenty-nine morphological measurements were taken on 302 mid-sagittal MR images of adult female CMI patients (n=162) and healthy controls (n=140). All MR images were voluntarily provided by CMI subjects through an online database and control participant images were obtained through the Human Connectome Project and a local hospital system. RESULTS: Analyses were performed on the full dataset of adult female MR images and a restricted dataset of 229 participants that were equated for age, race, and body mass index. Eighteen group differences were identified in the PCF area that we grouped into three clusters; PCF structures heights, clivus angulation, and odontoid process irregularity. Fourteen group differences persisted after equating our CMI and control groups on demographic characteristics. CONCLUSION: PCF structures reliably differ in adult female CMI patients relative to healthy controls. These differences reflect structural abnormalities in the osseous and soft tissue structures of the clivus, odontoid process, and cerebellum. Clinical and pathophysiological implications are discussed. SN - 0150-9861 UR - https://www.unboundmedicine.com/medline/citation/28826656/A_morphometric_assessment_of_type_I_Chiari_malformation_above_the_McRae_line:_A_retrospective_case_control_study_in_302_adult_female_subjects_ DB - PRIME DP - Unbound Medicine ER -