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Rutin alleviates diabetic cardiomyopathy and improves cardiac function in diabetic ApoEknockout mice.
Eur J Pharmacol 2017; 814:151-160EJ

Abstract

Rutin, a natural bioflavonoid, has demonstrated anti-diabetic and anti-oxidative bioactivity. Oxidative stress is a potential therapeutic target for diabetic cardiomyopathy. We investigated whether rutinadministration (60mg/kg body weight) reduces diabetic cardiomyopathy in a diabetic ApoE knock out mouse model. Diabetes was induced in ApoEknockout mice (male, C57BL/6 background) with a high fat diet combined with injection of streptozotocin. Cardiac function was evaluated by echocardiography and cardiac catheter hemodynamic analysis. Cardiac myocardial hypertrophy, myocardial fibrosis, lipid content, myocardial capillary density, and oxidative stress were detected by a series of histopathological analyses, western blotting, and reactive oxygen species analysis. Diabetic mice showed myocardial hypertrophy, lipid accumulation, myocardial fibrosis, elevated collagen content, deteriorating oxidative stress, and left ventricular systolic and diastolic dysfunction. Rutin reversed the myocardial hypertrophy, alleviated extracellular collagen deposition, and lipid accumulation, but increased capillary density in diabetic myocardial tissues. Moreover, rutin substantially improved cardiac function while decreasing blood glucose and lipid content. Therapeutic rutin administration reduced cardiac remodeling and improved myocardial function in diabetic mice, at least in part by reducing oxidative damage and ectopic lipid deposition, inhibiting fibrosis, and promoting angiogenesis. Thus, rutin may represent a potential therapeutic agent for diabetic cardiomyopathy.

Authors+Show Affiliations

Department of Cardiology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China; Department of Geriatric Medicine, Lai Wu City People's Hospital, Laiwu, Shandong 271100, China.Laiwu Municipal Center for Disease Control and Prevention, Laiwu, Shandong 271100, China.Department of Geriatric Medicine, Lai Wu City People's Hospital, Laiwu, Shandong 271100, China.Department of Geriatric Medicine, Lai Wu City People's Hospital, Laiwu, Shandong 271100, China.Department of Geriatric Medicine, Lai Wu City People's Hospital, Laiwu, Shandong 271100, China.Department of Cardiology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China. Electronic address: sdqdanyi@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28826911

Citation

Huang, Ruo, et al. "Rutin Alleviates Diabetic Cardiomyopathy and Improves Cardiac Function in Diabetic ApoEknockout Mice." European Journal of Pharmacology, vol. 814, 2017, pp. 151-160.
Huang R, Shi Z, Chen L, et al. Rutin alleviates diabetic cardiomyopathy and improves cardiac function in diabetic ApoEknockout mice. Eur J Pharmacol. 2017;814:151-160.
Huang, R., Shi, Z., Chen, L., Zhang, Y., Li, J., & An, Y. (2017). Rutin alleviates diabetic cardiomyopathy and improves cardiac function in diabetic ApoEknockout mice. European Journal of Pharmacology, 814, pp. 151-160. doi:10.1016/j.ejphar.2017.08.023.
Huang R, et al. Rutin Alleviates Diabetic Cardiomyopathy and Improves Cardiac Function in Diabetic ApoEknockout Mice. Eur J Pharmacol. 2017 Nov 5;814:151-160. PubMed PMID: 28826911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin alleviates diabetic cardiomyopathy and improves cardiac function in diabetic ApoEknockout mice. AU - Huang,Ruo, AU - Shi,Zhendong, AU - Chen,Li, AU - Zhang,Yanqun, AU - Li,Jing, AU - An,Yi, Y1 - 2017/08/19/ PY - 2017/04/05/received PY - 2017/08/16/revised PY - 2017/08/18/accepted PY - 2017/8/23/pubmed PY - 2018/6/2/medline PY - 2017/8/23/entrez KW - Cardiomyopathy KW - Diabetes KW - Myocardial dysfunction KW - Oxidative stress KW - Rutin SP - 151 EP - 160 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 814 N2 - Rutin, a natural bioflavonoid, has demonstrated anti-diabetic and anti-oxidative bioactivity. Oxidative stress is a potential therapeutic target for diabetic cardiomyopathy. We investigated whether rutinadministration (60mg/kg body weight) reduces diabetic cardiomyopathy in a diabetic ApoE knock out mouse model. Diabetes was induced in ApoEknockout mice (male, C57BL/6 background) with a high fat diet combined with injection of streptozotocin. Cardiac function was evaluated by echocardiography and cardiac catheter hemodynamic analysis. Cardiac myocardial hypertrophy, myocardial fibrosis, lipid content, myocardial capillary density, and oxidative stress were detected by a series of histopathological analyses, western blotting, and reactive oxygen species analysis. Diabetic mice showed myocardial hypertrophy, lipid accumulation, myocardial fibrosis, elevated collagen content, deteriorating oxidative stress, and left ventricular systolic and diastolic dysfunction. Rutin reversed the myocardial hypertrophy, alleviated extracellular collagen deposition, and lipid accumulation, but increased capillary density in diabetic myocardial tissues. Moreover, rutin substantially improved cardiac function while decreasing blood glucose and lipid content. Therapeutic rutin administration reduced cardiac remodeling and improved myocardial function in diabetic mice, at least in part by reducing oxidative damage and ectopic lipid deposition, inhibiting fibrosis, and promoting angiogenesis. Thus, rutin may represent a potential therapeutic agent for diabetic cardiomyopathy. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/28826911/Rutin_alleviates_diabetic_cardiomyopathy_and_improves_cardiac_function_in_diabetic_ApoEknockout_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(17)30538-1 DB - PRIME DP - Unbound Medicine ER -