Tags

Type your tag names separated by a space and hit enter

Identification of PGC-1α activating constituents in Zingiberaceous crude drugs.
Fitoterapia. 2017 Oct; 122:40-44.F

Abstract

The activity of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) as an index of thermogenesis induced by four Indonesian Zingiberaceous crude drugs, Boesenbergia rotunda, Curcuma longa, Kaempferia galanga, Zingiber montanum, was examined, and GC-MS analyses of extracts of these drugs were performed. The results showed that activation of PGC-1α by K. galanga was high, whereas no activation was shown for the other drugs. Ethyl p-methoxycinnamate and ethyl cinnamate were identified as the PGC-1α activating compounds of K. galanga. Furthermore, study on the structure-activity relationship revealed that ethyl p-methoxycinnamate has the strongest activity among the cinnamic acid derivatives. This suggests that the ester structure and the methoxy group are important factors responsible for the PGC-1α activity.

Authors+Show Affiliations

College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.Sumitomo Chemical Asia PTE Ltd., 150 Beach Road, #17-07 Gateway West, 189720, Singapore.Graduate School of Life Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.College of Pharmaceutical Science, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan. Electronic address: ktanaka@fc.ritsumei.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28827002

Citation

Nishidono, Yuto, et al. "Identification of PGC-1α Activating Constituents in Zingiberaceous Crude Drugs." Fitoterapia, vol. 122, 2017, pp. 40-44.
Nishidono Y, Fujita T, Kawanami A, et al. Identification of PGC-1α activating constituents in Zingiberaceous crude drugs. Fitoterapia. 2017;122:40-44.
Nishidono, Y., Fujita, T., Kawanami, A., Nishizawa, M., & Tanaka, K. (2017). Identification of PGC-1α activating constituents in Zingiberaceous crude drugs. Fitoterapia, 122, 40-44. https://doi.org/10.1016/j.fitote.2017.08.007
Nishidono Y, et al. Identification of PGC-1α Activating Constituents in Zingiberaceous Crude Drugs. Fitoterapia. 2017;122:40-44. PubMed PMID: 28827002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of PGC-1α activating constituents in Zingiberaceous crude drugs. AU - Nishidono,Yuto, AU - Fujita,Takashi, AU - Kawanami,Akira, AU - Nishizawa,Mikio, AU - Tanaka,Ken, Y1 - 2017/08/18/ PY - 2017/07/14/received PY - 2017/08/14/revised PY - 2017/08/17/accepted PY - 2017/8/23/pubmed PY - 2017/11/4/medline PY - 2017/8/23/entrez KW - Ethyl p-methoxycinnamate KW - Kaempferia galanga KW - PGC-1α KW - Zingiberaceae SP - 40 EP - 44 JF - Fitoterapia JO - Fitoterapia VL - 122 N2 - The activity of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) as an index of thermogenesis induced by four Indonesian Zingiberaceous crude drugs, Boesenbergia rotunda, Curcuma longa, Kaempferia galanga, Zingiber montanum, was examined, and GC-MS analyses of extracts of these drugs were performed. The results showed that activation of PGC-1α by K. galanga was high, whereas no activation was shown for the other drugs. Ethyl p-methoxycinnamate and ethyl cinnamate were identified as the PGC-1α activating compounds of K. galanga. Furthermore, study on the structure-activity relationship revealed that ethyl p-methoxycinnamate has the strongest activity among the cinnamic acid derivatives. This suggests that the ester structure and the methoxy group are important factors responsible for the PGC-1α activity. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/28827002/Identification_of_PGC_1α_activating_constituents_in_Zingiberaceous_crude_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(17)31006-7 DB - PRIME DP - Unbound Medicine ER -