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Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study.
Parkinsonism Relat Disord. 2017 Nov; 44:18-22.PR

Abstract

BACKGROUND

We investigated the prevalence and impact of restless legs syndrome (RLS) and leg motor restlessness (LMR) in patients with Parkinson's disease (PD) in a multicenter study.

METHODS

A total of 436 PD patients and 401 age- and sex-matched controls were included in this study. RLS was diagnosed based on four essential features. LMR was diagnosed when a participant exhibited the urge to move his or her legs but did not meet the four essential features of RLS.

RESULTS

The RLS prevalence did not differ between PD patients and controls (3.4% vs. 2.7%), while LMR prevalence was significantly higher in PD patients than in controls (12.8% vs. 4.5%). PD patients with RLS or LMR had a higher prevalence of excessive daytime sleepiness (EDS) (50.7%, vs. 6.9%), probable REM sleep behavior disorder (38.0% vs. 3.4%) and PD-related sleep problems (49.3% vs. 20.7%) than controls with RLS or LMR. RLS/LMR preceding PD onset was related to an older age of PD onset.

CONCLUSION

Our study revealed an increased prevalence of LMR but not RLS in PD patients. LMR could be an early manifestation of PD; however, whether LMR is within the range of RLS or whether LMR and RLS constitute different entities in PD requires further studies.

Authors+Show Affiliations

Department of Neurology, Dokkyo Medical University, Tochigi, Japan. Electronic address: keisuke@dokkyomed.ac.jp.Department of Neurology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.Department of Neurology, Dokkyo Medical University, Tochigi, Japan; Neuro-urology and Continence Center, Dokkyo Medical University Hospital, Tochigi, Japan.Department of Clinical Medicine for Nursing, Dokkyo Medical University School of Nursing, Tochigi, Japan.Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.Department of Neurology, Saitama Medical University, Saitama, Japan.Department of Neurology, Dokkyo Medical University, Tochigi, Japan.Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.Department of Neurology, Dokkyo Medical University, Tochigi, Japan.Department of Neurology, Dokkyo Medical University, Tochigi, Japan.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28827009

Citation

Suzuki, Keisuke, et al. "Characterizing Restless Legs Syndrome and Leg Motor Restlessness in Patients With Parkinson's Disease: a Multicenter Case-controlled Study." Parkinsonism & Related Disorders, vol. 44, 2017, pp. 18-22.
Suzuki K, Okuma Y, Uchiyama T, et al. Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study. Parkinsonism Relat Disord. 2017;44:18-22.
Suzuki, K., Okuma, Y., Uchiyama, T., Miyamoto, M., Sakakibara, R., Shimo, Y., Hattori, N., Kuwabara, S., Yamamoto, T., Kaji, Y., Hirano, S., Numao, A., & Hirata, K. (2017). Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study. Parkinsonism & Related Disorders, 44, 18-22. https://doi.org/10.1016/j.parkreldis.2017.08.007
Suzuki K, et al. Characterizing Restless Legs Syndrome and Leg Motor Restlessness in Patients With Parkinson's Disease: a Multicenter Case-controlled Study. Parkinsonism Relat Disord. 2017;44:18-22. PubMed PMID: 28827009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson's disease: A multicenter case-controlled study. AU - Suzuki,Keisuke, AU - Okuma,Yasuyuki, AU - Uchiyama,Tomoyuki, AU - Miyamoto,Masayuki, AU - Sakakibara,Ryuji, AU - Shimo,Yasushi, AU - Hattori,Nobutaka, AU - Kuwabara,Satoshi, AU - Yamamoto,Toshimasa, AU - Kaji,Yoshiaki, AU - Hirano,Shigeki, AU - Numao,Ayaka, AU - Hirata,Koichi, AU - ,, Y1 - 2017/08/14/ PY - 2017/04/01/received PY - 2017/07/29/revised PY - 2017/08/08/accepted PY - 2017/8/23/pubmed PY - 2018/7/28/medline PY - 2017/8/23/entrez KW - Leg motor restlessness KW - Parkinson's disease KW - Restless legs syndrome SP - 18 EP - 22 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 44 N2 - BACKGROUND: We investigated the prevalence and impact of restless legs syndrome (RLS) and leg motor restlessness (LMR) in patients with Parkinson's disease (PD) in a multicenter study. METHODS: A total of 436 PD patients and 401 age- and sex-matched controls were included in this study. RLS was diagnosed based on four essential features. LMR was diagnosed when a participant exhibited the urge to move his or her legs but did not meet the four essential features of RLS. RESULTS: The RLS prevalence did not differ between PD patients and controls (3.4% vs. 2.7%), while LMR prevalence was significantly higher in PD patients than in controls (12.8% vs. 4.5%). PD patients with RLS or LMR had a higher prevalence of excessive daytime sleepiness (EDS) (50.7%, vs. 6.9%), probable REM sleep behavior disorder (38.0% vs. 3.4%) and PD-related sleep problems (49.3% vs. 20.7%) than controls with RLS or LMR. RLS/LMR preceding PD onset was related to an older age of PD onset. CONCLUSION: Our study revealed an increased prevalence of LMR but not RLS in PD patients. LMR could be an early manifestation of PD; however, whether LMR is within the range of RLS or whether LMR and RLS constitute different entities in PD requires further studies. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/28827009/Characterizing_restless_legs_syndrome_and_leg_motor_restlessness_in_patients_with_Parkinson's_disease:_A_multicenter_case_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(17)30288-2 DB - PRIME DP - Unbound Medicine ER -