Tags

Type your tag names separated by a space and hit enter

Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial.
J Altern Complement Med. 2018 Mar; 24(3):243-248.JA

Abstract

BACKGROUND

Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions.

OBJECTIVE

This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients.

DESIGN, SETTING, AND PARTICIPANTS

A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016. Fifty subjects with elevated serum thyroid stimulating hormone (TSH) levels (4.5-10 μIU/L) aged between 18 and 50 were randomized in either treatment (n = 25) or placebo (n = 25) groups for an 8-week treatment period.

INTERVENTIONS

Ashwagandha root extract (600 mg daily) or starch as placebo. Efficacy Variables: Serum TSH, serum triiodothyronine (T3), and thyroxine (T4) levels.

RESULTS

A total of four subjects (two from each group) withdrew their consent before the second visit. Eight weeks of treatment with ashwagandha improved serum TSH (p < 0.001), T3 (p = 0.0031), and T4 (p = 0.0096) levels significantly compared to placebo. Ashwagandha treatment effectively normalized the serum thyroid indices during the 8-week treatment period in a significant manner (time-effects: TSH [p < 0.001], T3 [p < 0.001], and T4 [p < 0.001]). Four subjects (8%) (ashwagandha: 1[4%]; Placebo: 3[12%]) out of 50 reported few mild and temporary adverse effects during this study.

CONCLUSION

Treatment with ashwagandha may be beneficial for normalizing thyroid indices in subclinical hypothyroid patients.

Authors+Show Affiliations

Consultant Physician, Sudbhawana Hospital , Varanasi, India .Consultant Physician, Sudbhawana Hospital , Varanasi, India .Consultant Physician, Sudbhawana Hospital , Varanasi, India .

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28829155

Citation

Sharma, Ashok Kumar, et al. "Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: a Double-Blind, Randomized Placebo-Controlled Trial." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 24, no. 3, 2018, pp. 243-248.
Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med. 2018;24(3):243-248.
Sharma, A. K., Basu, I., & Singh, S. (2018). Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. Journal of Alternative and Complementary Medicine (New York, N.Y.), 24(3), 243-248. https://doi.org/10.1089/acm.2017.0183
Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: a Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med. 2018;24(3):243-248. PubMed PMID: 28829155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. AU - Sharma,Ashok Kumar, AU - Basu,Indraneel, AU - Singh,Siddarth, Y1 - 2017/08/22/ PY - 2017/8/23/pubmed PY - 2018/5/15/medline PY - 2017/8/23/entrez KW - Withania somnifera (L.) Dunal, KW - ashwagandha KW - efficacy KW - safety KW - subclinical hypothyroidism SP - 243 EP - 248 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 24 IS - 3 N2 - BACKGROUND: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions. OBJECTIVE: This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients. DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016. Fifty subjects with elevated serum thyroid stimulating hormone (TSH) levels (4.5-10 μIU/L) aged between 18 and 50 were randomized in either treatment (n = 25) or placebo (n = 25) groups for an 8-week treatment period. INTERVENTIONS: Ashwagandha root extract (600 mg daily) or starch as placebo. Efficacy Variables: Serum TSH, serum triiodothyronine (T3), and thyroxine (T4) levels. RESULTS: A total of four subjects (two from each group) withdrew their consent before the second visit. Eight weeks of treatment with ashwagandha improved serum TSH (p < 0.001), T3 (p = 0.0031), and T4 (p = 0.0096) levels significantly compared to placebo. Ashwagandha treatment effectively normalized the serum thyroid indices during the 8-week treatment period in a significant manner (time-effects: TSH [p < 0.001], T3 [p < 0.001], and T4 [p < 0.001]). Four subjects (8%) (ashwagandha: 1[4%]; Placebo: 3[12%]) out of 50 reported few mild and temporary adverse effects during this study. CONCLUSION: Treatment with ashwagandha may be beneficial for normalizing thyroid indices in subclinical hypothyroid patients. SN - 1557-7708 UR - https://www.unboundmedicine.com/medline/citation/28829155/Efficacy_and_Safety_of_Ashwagandha_Root_Extract_in_Subclinical_Hypothyroid_Patients:_A_Double_Blind_Randomized_Placebo_Controlled_Trial_ L2 - https://www.liebertpub.com/doi/10.1089/acm.2017.0183?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -