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Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS.
J Anal Toxicol. 2017 07 01; 41(6):493-497.JA

Abstract

Recently, it has been documented that there has been a rise in synthetic opioid abuse. Synthetic opioids are compounds that were created to act as agonists for the opioid receptors. Like synthetic cannabinoids, most of these compounds were created by research groups or pharmaceutical companies in an attempt to find compounds that have medicinal use. Synthetic opioids have severe health implications when abused that can include hospitalization and death. Due to the high potency and the low dose required to produce the desired effects for these compounds, it was hypothesized that they may not be detectable in human performance case samples. However, this report documents a male driver who was involved in a single-vehicle incident. First responders treated the subject with naloxone as opioid drug impairment was suspected and he was transported to the local emergency room. The subject consented to a blood draw for a driving under the influence (DUI) investigation. Initial routine testing identified alprazolam at 55 ng/mL and fentanyl at less than 0.5 ng/mL. Further testing using a validated liquid chromatography-tandem mass spectrometry (LC-MS-MS) assay, confirmed the presence of carfentanil, furanyl fentanyl, para-fluoroisobutyryl fentanyl, U-47700 and its metabolite. To the author's knowledge, this is the first report of a DUI cases where carfentanil, U-47700 and other synthetic opioids were confirmed and described in a human performance blood sample. This case demonstrates the need to supplement routine toxicological analyses with a sensitive methodology that can detect synthetic opioids in human performance cases where opioid use may be implicated.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Rosenstiel Medical Science Building (RMSB), 1600 NW 10th Avenue, 7th Floor Suite 7020 (R-5), Miami, FL 33136, USA.Email: lreidy@med.miami.edu

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28830119

Citation

Seither, Joshua, and Lisa Reidy. "Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case By LC-MS-MS." Journal of Analytical Toxicology, vol. 41, no. 6, 2017, pp. 493-497.
Seither J, Reidy L. Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS. J Anal Toxicol. 2017;41(6):493-497.
Seither, J., & Reidy, L. (2017). Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS. Journal of Analytical Toxicology, 41(6), 493-497. https://doi.org/10.1093/jat/bkx049
Seither J, Reidy L. Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case By LC-MS-MS. J Anal Toxicol. 2017 07 1;41(6):493-497. PubMed PMID: 28830119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC-MS-MS. AU - Seither,Joshua, AU - Reidy,Lisa, PY - 2017/01/27/received PY - 2017/06/21/accepted PY - 2017/8/24/entrez PY - 2017/8/24/pubmed PY - 2017/12/21/medline SP - 493 EP - 497 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 41 IS - 6 N2 - Recently, it has been documented that there has been a rise in synthetic opioid abuse. Synthetic opioids are compounds that were created to act as agonists for the opioid receptors. Like synthetic cannabinoids, most of these compounds were created by research groups or pharmaceutical companies in an attempt to find compounds that have medicinal use. Synthetic opioids have severe health implications when abused that can include hospitalization and death. Due to the high potency and the low dose required to produce the desired effects for these compounds, it was hypothesized that they may not be detectable in human performance case samples. However, this report documents a male driver who was involved in a single-vehicle incident. First responders treated the subject with naloxone as opioid drug impairment was suspected and he was transported to the local emergency room. The subject consented to a blood draw for a driving under the influence (DUI) investigation. Initial routine testing identified alprazolam at 55 ng/mL and fentanyl at less than 0.5 ng/mL. Further testing using a validated liquid chromatography-tandem mass spectrometry (LC-MS-MS) assay, confirmed the presence of carfentanil, furanyl fentanyl, para-fluoroisobutyryl fentanyl, U-47700 and its metabolite. To the author's knowledge, this is the first report of a DUI cases where carfentanil, U-47700 and other synthetic opioids were confirmed and described in a human performance blood sample. This case demonstrates the need to supplement routine toxicological analyses with a sensitive methodology that can detect synthetic opioids in human performance cases where opioid use may be implicated. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/28830119/Confirmation_of_Carfentanil_U_47700_and_Other_Synthetic_Opioids_in_a_Human_Performance_Case_by_LC_MS_MS_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkx049 DB - PRIME DP - Unbound Medicine ER -