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Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients.
Br J Radiol. 2017 Nov; 90(1079):20170311.BJ

Abstract

OBJECTIVE

The aim of the study was to evaluate the CT and fluorine-18-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) imaging findings of lung mucosa associated lymphoid tissue (MALT) lymphoma.

METHODS

28 patients with histologically confirmed pulmonary MALT lymphoma who underwent a chest CT and 18F-FDG PET/CT for staging were retrospectively analysed. The CT images were evaluated to determine morphological pattern of appearance, laterality, localization, number, size, presence of thoracic lymphadenopaties and secondary/combined findings. PET images were analysed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax), lesion-to-liver SUVmax ratio and lesion-to-blood pool SUVmax ratio. The relationship between qualitative and semi-quantitative features at 18F-FDG PET/CT and CT findings were also analysed.

RESULTS

A total of 57 pulmonary lesions were identified by CT: 37 areas of consolidation, 4 masses, 12 nodules and 4 ground-glass opacities. Solitary and multiple lesions were detected in 10 and 18 patients, respectively; among patients with multiple lesions, 16 were bilateral and 2 unilateral. 18F-FDG PET/CT revealed increased 18F-FDG uptake in 47/57 lesions, in 26/28 patients. 18F-FDG avidity was significantly associated only with tumour size.

CONCLUSIONS

Pulmonary MALT lymphoma is 18F-FDG avid in most cases and 18F-FDG avidity is correlated with tumour size. Consolidation is the most frequent morphological pattern of disease presentation. Advances in knowledge: This study demonstrated that lung MALT lymphoma are 18F-FDG avid in most cases depending on tumour size. Single or multiple areas of consolidation are the most common pattern of presentation of lung MALT lymphoma at CT.

Authors+Show Affiliations

1 Nuclear Medicine, Spedali Civili Brescia, Brescia, Italy.2 Department of Radiology, University of Brescia and Spedali Civili Brescia, Brescia, Italy.1 Nuclear Medicine, Spedali Civili Brescia, Brescia, Italy.1 Nuclear Medicine, Spedali Civili Brescia, Brescia, Italy.2 Department of Radiology, University of Brescia and Spedali Civili Brescia, Brescia, Italy.3 Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.3 Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28830222

Citation

Albano, Domenico, et al. "Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma: 18F-FDG PET/CT and CT Findings in 28 Patients." The British Journal of Radiology, vol. 90, no. 1079, 2017, p. 20170311.
Albano D, Borghesi A, Bosio G, et al. Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients. Br J Radiol. 2017;90(1079):20170311.
Albano, D., Borghesi, A., Bosio, G., Bertoli, M., Maroldi, R., Giubbini, R., & Bertagna, F. (2017). Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients. The British Journal of Radiology, 90(1079), 20170311. https://doi.org/10.1259/bjr.20170311
Albano D, et al. Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma: 18F-FDG PET/CT and CT Findings in 28 Patients. Br J Radiol. 2017;90(1079):20170311. PubMed PMID: 28830222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary mucosa-associated lymphoid tissue lymphoma: 18F-FDG PET/CT and CT findings in 28 patients. AU - Albano,Domenico, AU - Borghesi,Andrea, AU - Bosio,Giovanni, AU - Bertoli,Mattia, AU - Maroldi,Roberto, AU - Giubbini,Raffaele, AU - Bertagna,Francesco, Y1 - 2017/10/03/ PY - 2017/8/24/pubmed PY - 2017/10/19/medline PY - 2017/8/24/entrez SP - 20170311 EP - 20170311 JF - The British journal of radiology JO - Br J Radiol VL - 90 IS - 1079 N2 - OBJECTIVE: The aim of the study was to evaluate the CT and fluorine-18-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) imaging findings of lung mucosa associated lymphoid tissue (MALT) lymphoma. METHODS: 28 patients with histologically confirmed pulmonary MALT lymphoma who underwent a chest CT and 18F-FDG PET/CT for staging were retrospectively analysed. The CT images were evaluated to determine morphological pattern of appearance, laterality, localization, number, size, presence of thoracic lymphadenopaties and secondary/combined findings. PET images were analysed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax), lesion-to-liver SUVmax ratio and lesion-to-blood pool SUVmax ratio. The relationship between qualitative and semi-quantitative features at 18F-FDG PET/CT and CT findings were also analysed. RESULTS: A total of 57 pulmonary lesions were identified by CT: 37 areas of consolidation, 4 masses, 12 nodules and 4 ground-glass opacities. Solitary and multiple lesions were detected in 10 and 18 patients, respectively; among patients with multiple lesions, 16 were bilateral and 2 unilateral. 18F-FDG PET/CT revealed increased 18F-FDG uptake in 47/57 lesions, in 26/28 patients. 18F-FDG avidity was significantly associated only with tumour size. CONCLUSIONS: Pulmonary MALT lymphoma is 18F-FDG avid in most cases and 18F-FDG avidity is correlated with tumour size. Consolidation is the most frequent morphological pattern of disease presentation. Advances in knowledge: This study demonstrated that lung MALT lymphoma are 18F-FDG avid in most cases depending on tumour size. Single or multiple areas of consolidation are the most common pattern of presentation of lung MALT lymphoma at CT. SN - 1748-880X UR - https://www.unboundmedicine.com/medline/citation/28830222/Pulmonary_mucosa_associated_lymphoid_tissue_lymphoma:_18F_FDG_PET/CT_and_CT_findings_in_28_patients_ L2 - http://www.birpublications.org/doi/full/10.1259/bjr.20170311?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -