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Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1.
Biosci Biotechnol Biochem. 2017 Oct; 81(10):1908-1916.BB

Abstract

The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement.

Authors+Show Affiliations

a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin , P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28831863

Citation

Zhao, Xuan, et al. "Emodin Extends Lifespan of Caenorhabditis Elegans Through insulin/IGF-1 Signaling Pathway Depending On DAF-16 and SIR-2.1." Bioscience, Biotechnology, and Biochemistry, vol. 81, no. 10, 2017, pp. 1908-1916.
Zhao X, Lu L, Qi Y, et al. Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1. Biosci Biotechnol Biochem. 2017;81(10):1908-1916.
Zhao, X., Lu, L., Qi, Y., Li, M., & Zhou, L. (2017). Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1. Bioscience, Biotechnology, and Biochemistry, 81(10), 1908-1916. https://doi.org/10.1080/09168451.2017.1365592
Zhao X, et al. Emodin Extends Lifespan of Caenorhabditis Elegans Through insulin/IGF-1 Signaling Pathway Depending On DAF-16 and SIR-2.1. Biosci Biotechnol Biochem. 2017;81(10):1908-1916. PubMed PMID: 28831863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1. AU - Zhao,Xuan, AU - Lu,Lulu, AU - Qi,Yonghao, AU - Li,Miao, AU - Zhou,Lijun, Y1 - 2017/08/23/ PY - 2017/8/24/pubmed PY - 2017/10/19/medline PY - 2017/8/24/entrez KW - DAF-16 KW - SIR-2.1 KW - emodin KW - insulin/IGF-1 signaling pathway KW - lifespan SP - 1908 EP - 1916 JF - Bioscience, biotechnology, and biochemistry JO - Biosci. Biotechnol. Biochem. VL - 81 IS - 10 N2 - The naturally occurring anthraquinone emodin has been serving primarily as an anti-bacterial and anti-inflammatory agent. However, little is known about its potential on anti-aging. This investigation examined the effect of emodin on lifespan and focused on its physiological molecular mechanisms in vivo. Using Caenorhabditis elegans (C. elegans) as an animal model, we found emodin could extend lifespan of worms and improve their antioxidant capacity. Our mechanistic studies revealed that emodin might function via insulin/IGF-1 signaling (IIS) pathway involving, specifically the core transcription factor DAF-16. Quantitative RT-PCR results illustrated that emodin up-regulated transcription of DAF-16 target genes which express antioxidants to promote antioxidant capacity and lifespan of worms. In addition, attenuated effect in sir-2.1 mutants suggests that emodin likely functioned in a SIR-2.1-dependent manner. Our study uncovers a novel role of emodin in prolonging lifespan and supports the understanding of emodin being a beneficial dietary supplement. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/28831863/Emodin_extends_lifespan_of_Caenorhabditis_elegans_through_insulin/IGF_1_signaling_pathway_depending_on_DAF_16_and_SIR_2_1_ L2 - http://www.tandfonline.com/doi/full/10.1080/09168451.2017.1365592 DB - PRIME DP - Unbound Medicine ER -