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Exploiting the high oxidation potential of carisoprodol on a boron-doped diamond electrode: an improved method for its simultaneous determination with acetaminophen and caffeine.
Analyst. 2017 Sep 08; 142(18):3514-3521.A

Abstract

A boron-doped diamond electrode (BDDE) was employed for the first time in the development of a voltammetric method for the simultaneous determination of acetaminophen (ACT), caffeine (CAF) and carisoprodol (CAR). CAR presents a high oxidation potential (2.0 V) and this electrode is suitable for this purpose due to its wide electrochemical potential window. The anodic peak potentials of ACT, CAF and CAR oxidation on the BDDE were found to be 0.980 V, 1.50 V and 2.03 V (vs. Ag/AgCl (3.0 mol L-1 KCl)), respectively, by cyclic voltammetry. After optimization of the analytical conditions employing BDDE at pH 6.0 in a Britton-Robinson buffer solution, square-wave voltammetry (SWV) was applied to the simultaneous determination, by which the peak currents for the three molecules were found to vary linearly with their concentrations in the range of 2.99-283 μmol L-1 for ACT, 2.99-84.8 μmol L-1 for CAF and 19.9-207 μmol L-1 for CAR, with detection limits of 0.768 μmol L-1, 0.771 μmol L-1, and 3.11 μmol L-1, respectively. The proposed method was employed for the simultaneous determination of the three molecules in pharmaceutical formulations and the results were successfully validated with a comparative spectrophotometric method. The use of BDDE showed advantages such as low cost, suitable linearity for simultaneous quantification in real samples, no adsorption problems, and possessing rapidity and excellent reproducibility. This electrode represents a suitable electrochemical sensor for the routine analysis of these drugs.

Authors+Show Affiliations

Universidade Estadual de Londrina (UEL), Centro de Ciências Exatas, Departamento de Química, Rodovia Celso Garcia Cid, PR 445 Km 380, Londrina - PR, C.P. 10.011 86057-970, Brazil. elensartori@uel.br.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28832032

Citation

Eisele, Ana Paula Pires, et al. "Exploiting the High Oxidation Potential of Carisoprodol On a Boron-doped Diamond Electrode: an Improved Method for Its Simultaneous Determination With Acetaminophen and Caffeine." The Analyst, vol. 142, no. 18, 2017, pp. 3514-3521.
Eisele APP, Valezi CF, Sartori ER. Exploiting the high oxidation potential of carisoprodol on a boron-doped diamond electrode: an improved method for its simultaneous determination with acetaminophen and caffeine. Analyst. 2017;142(18):3514-3521.
Eisele, A. P. P., Valezi, C. F., & Sartori, E. R. (2017). Exploiting the high oxidation potential of carisoprodol on a boron-doped diamond electrode: an improved method for its simultaneous determination with acetaminophen and caffeine. The Analyst, 142(18), 3514-3521. https://doi.org/10.1039/c7an01074e
Eisele APP, Valezi CF, Sartori ER. Exploiting the High Oxidation Potential of Carisoprodol On a Boron-doped Diamond Electrode: an Improved Method for Its Simultaneous Determination With Acetaminophen and Caffeine. Analyst. 2017 Sep 8;142(18):3514-3521. PubMed PMID: 28832032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploiting the high oxidation potential of carisoprodol on a boron-doped diamond electrode: an improved method for its simultaneous determination with acetaminophen and caffeine. AU - Eisele,Ana Paula Pires, AU - Valezi,Camila Farinha, AU - Sartori,Elen Romão, PY - 2017/8/24/pubmed PY - 2018/12/12/medline PY - 2017/8/24/entrez SP - 3514 EP - 3521 JF - The Analyst JO - Analyst VL - 142 IS - 18 N2 - A boron-doped diamond electrode (BDDE) was employed for the first time in the development of a voltammetric method for the simultaneous determination of acetaminophen (ACT), caffeine (CAF) and carisoprodol (CAR). CAR presents a high oxidation potential (2.0 V) and this electrode is suitable for this purpose due to its wide electrochemical potential window. The anodic peak potentials of ACT, CAF and CAR oxidation on the BDDE were found to be 0.980 V, 1.50 V and 2.03 V (vs. Ag/AgCl (3.0 mol L-1 KCl)), respectively, by cyclic voltammetry. After optimization of the analytical conditions employing BDDE at pH 6.0 in a Britton-Robinson buffer solution, square-wave voltammetry (SWV) was applied to the simultaneous determination, by which the peak currents for the three molecules were found to vary linearly with their concentrations in the range of 2.99-283 μmol L-1 for ACT, 2.99-84.8 μmol L-1 for CAF and 19.9-207 μmol L-1 for CAR, with detection limits of 0.768 μmol L-1, 0.771 μmol L-1, and 3.11 μmol L-1, respectively. The proposed method was employed for the simultaneous determination of the three molecules in pharmaceutical formulations and the results were successfully validated with a comparative spectrophotometric method. The use of BDDE showed advantages such as low cost, suitable linearity for simultaneous quantification in real samples, no adsorption problems, and possessing rapidity and excellent reproducibility. This electrode represents a suitable electrochemical sensor for the routine analysis of these drugs. SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/28832032/Exploiting_the_high_oxidation_potential_of_carisoprodol_on_a_boron_doped_diamond_electrode:_an_improved_method_for_its_simultaneous_determination_with_acetaminophen_and_caffeine_ L2 - https://doi.org/10.1039/c7an01074e DB - PRIME DP - Unbound Medicine ER -