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Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults.
Metab Syndr Relat Disord 2017; 15(8):416-422MS

Abstract

BACKGROUND

Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults.

METHODS

We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis.

RESULTS

The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01).

CONCLUSIONS

Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD.

Authors+Show Affiliations

1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Mediplex Sejong Hospital , Incheon, South Korea .2 Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine , Incheon, South Korea .3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam, South Korea .3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam, South Korea .3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam, South Korea .4 Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University , Seoul, South Korea .5 Department of Preventive Medicine, Yonsei University College of Medicine , Seoul, South Korea . 6 Department of Preventive Medicine, Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine , Seoul, South Korea .4 Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University , Seoul, South Korea .3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam, South Korea .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28832275

Citation

Kim, Yoon Ji, et al. "Association Between Obesity and Chronic Kidney Disease, Defined By Both Glomerular Filtration Rate and Albuminuria, in Korean Adults." Metabolic Syndrome and Related Disorders, vol. 15, no. 8, 2017, pp. 416-422.
Kim YJ, Hwang SD, Oh TJ, et al. Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults. Metab Syndr Relat Disord. 2017;15(8):416-422.
Kim, Y. J., Hwang, S. D., Oh, T. J., Kim, K. M., Jang, H. C., Kimm, H., ... Lim, S. (2017). Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults. Metabolic Syndrome and Related Disorders, 15(8), pp. 416-422. doi:10.1089/met.2017.0053.
Kim YJ, et al. Association Between Obesity and Chronic Kidney Disease, Defined By Both Glomerular Filtration Rate and Albuminuria, in Korean Adults. Metab Syndr Relat Disord. 2017;15(8):416-422. PubMed PMID: 28832275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults. AU - Kim,Yoon Ji, AU - Hwang,Seun Deuk, AU - Oh,Tae Jung, AU - Kim,Kyoung Min, AU - Jang,Hak Chul, AU - Kimm,Heejin, AU - Kim,Hyeon Chang, AU - Jee,Sun Ha, AU - Lim,Soo, Y1 - 2017/08/23/ PY - 2017/8/24/pubmed PY - 2018/6/13/medline PY - 2017/8/24/entrez KW - albuminuria KW - chronic kidney disease KW - glomerular filtration rate KW - obesity SP - 416 EP - 422 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 15 IS - 8 N2 - BACKGROUND: Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults. METHODS: We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis. RESULTS: The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01). CONCLUSIONS: Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/28832275/Association_Between_Obesity_and_Chronic_Kidney_Disease_Defined_by_Both_Glomerular_Filtration_Rate_and_Albuminuria_in_Korean_Adults_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2017.0053?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -