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Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort.
Am J Clin Nutr 2017; 106(4):1113-1120AJ

Abstract

Background:

Consumption of coffee, one of the most popular beverages around the world, has been associated with a lower risk of cardiovascular and all-cause mortality in population-based studies. However, little is known about these associations in patient populations.

Objective:

This prospective study aimed to examine the consumption of caffeinated and decaffeinated coffee in relation to cardiovascular disease (CVD) mortality, ischemic heart disease (IHD) mortality, and all-cause mortality in patients with a prior myocardial infarction (MI).

Design:

We included 4365 Dutch patients from the Alpha Omega Cohort who were aged 60-80 y (21% female) and had experienced an MI <10 y before study enrollment. At baseline (2002-2006), dietary data including coffee consumption over the past month was collected with a 203-item validated food-frequency questionnaire. Causes of death were monitored until 1 January 2013. HRs for mortality in categories of coffee consumption were obtained from multivariable Cox proportional hazard models, adjusting for lifestyle and dietary factors.

Results:

Most patients (96%) drank coffee, and the median total coffee intake was 375 mL/d (∼3 cups/d). During a median follow-up of 7.1 y, a total of 945 deaths occurred, including 396 CVD-related and 266 IHD-related deaths. Coffee consumption was inversely associated with CVD mortality, with HRs of 0.69 (95% CI: 0.54, 0.89) for >2-4 cups/d and 0.72 (0.55, 0.95) for >4 cups/d, compared with 0-2 cups/d. Corresponding HRs were 0.77 (95% CI: 0.57, 1.05) and 0.68 (95% CI: 0.48, 0.95) for IHD mortality and 0.84 (95% CI: 0.71, 1.00) and 0.82 (95% CI: 0.68, 0.98) for all-cause mortality, respectively. Similar associations were found for decaffeinated coffee and for coffee with additives.

Conclusion:

Drinking coffee, either caffeinated or decaffeinated, may lower the risk of CVD and IHD mortality in patients with a prior MI. This study was registered at clinicaltrials.gov as NCT03192410.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; and.Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; and.Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; and.Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; and. Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; and marianne.geleijnse@wur.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28835365

Citation

van Dongen, Laura H., et al. "Coffee Consumption After Myocardial Infarction and Risk of Cardiovascular Mortality: a Prospective Analysis in the Alpha Omega Cohort." The American Journal of Clinical Nutrition, vol. 106, no. 4, 2017, pp. 1113-1120.
van Dongen LH, Mölenberg FJ, Soedamah-Muthu SS, et al. Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort. Am J Clin Nutr. 2017;106(4):1113-1120.
van Dongen, L. H., Mölenberg, F. J., Soedamah-Muthu, S. S., Kromhout, D., & Geleijnse, J. M. (2017). Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort. The American Journal of Clinical Nutrition, 106(4), pp. 1113-1120. doi:10.3945/ajcn.117.153338.
van Dongen LH, et al. Coffee Consumption After Myocardial Infarction and Risk of Cardiovascular Mortality: a Prospective Analysis in the Alpha Omega Cohort. Am J Clin Nutr. 2017;106(4):1113-1120. PubMed PMID: 28835365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort. AU - van Dongen,Laura H, AU - Mölenberg,Famke Jm, AU - Soedamah-Muthu,Sabita S, AU - Kromhout,Daan, AU - Geleijnse,Johanna M, Y1 - 2017/08/23/ PY - 2017/02/01/received PY - 2017/07/20/accepted PY - 2017/8/25/pubmed PY - 2017/10/14/medline PY - 2017/8/25/entrez KW - cardiovascular disease KW - coffee KW - ischemic heart disease KW - mortality KW - myocardial infarction patients KW - prospective cohort study SP - 1113 EP - 1120 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 106 IS - 4 N2 - Background: Consumption of coffee, one of the most popular beverages around the world, has been associated with a lower risk of cardiovascular and all-cause mortality in population-based studies. However, little is known about these associations in patient populations.Objective: This prospective study aimed to examine the consumption of caffeinated and decaffeinated coffee in relation to cardiovascular disease (CVD) mortality, ischemic heart disease (IHD) mortality, and all-cause mortality in patients with a prior myocardial infarction (MI).Design: We included 4365 Dutch patients from the Alpha Omega Cohort who were aged 60-80 y (21% female) and had experienced an MI <10 y before study enrollment. At baseline (2002-2006), dietary data including coffee consumption over the past month was collected with a 203-item validated food-frequency questionnaire. Causes of death were monitored until 1 January 2013. HRs for mortality in categories of coffee consumption were obtained from multivariable Cox proportional hazard models, adjusting for lifestyle and dietary factors.Results: Most patients (96%) drank coffee, and the median total coffee intake was 375 mL/d (∼3 cups/d). During a median follow-up of 7.1 y, a total of 945 deaths occurred, including 396 CVD-related and 266 IHD-related deaths. Coffee consumption was inversely associated with CVD mortality, with HRs of 0.69 (95% CI: 0.54, 0.89) for >2-4 cups/d and 0.72 (0.55, 0.95) for >4 cups/d, compared with 0-2 cups/d. Corresponding HRs were 0.77 (95% CI: 0.57, 1.05) and 0.68 (95% CI: 0.48, 0.95) for IHD mortality and 0.84 (95% CI: 0.71, 1.00) and 0.82 (95% CI: 0.68, 0.98) for all-cause mortality, respectively. Similar associations were found for decaffeinated coffee and for coffee with additives.Conclusion: Drinking coffee, either caffeinated or decaffeinated, may lower the risk of CVD and IHD mortality in patients with a prior MI. This study was registered at clinicaltrials.gov as NCT03192410. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/28835365/Coffee_consumption_after_myocardial_infarction_and_risk_of_cardiovascular_mortality:_a_prospective_analysis_in_the_Alpha_Omega_Cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.117.153338 DB - PRIME DP - Unbound Medicine ER -