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MicroRNAs in Neurodegenerative Diseases.
Int Rev Cell Mol Biol. 2017; 334:309-343.IR

Abstract

MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain. MicroRNAs have been described as the main regulator of homeostasis in neurons, and their dysregulation results in pathological conditions in the brain. In this review, we will focus on the role of MicroRNAs as novel drug targets and biomarkers of the three main neurodegenerative disorders (Alzheimer's disease, Parkinson's diseases, and Huntington's disease) and their role in other neurological disorders including traumatic brain injury and status epilepticus.

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Authors+Show Affiliations

Quinlan S
Royal College of Surgeons in Ireland, Dublin, Ireland.
Kenny A
Royal College of Surgeons in Ireland, Dublin, Ireland.
Medina M
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
Engel T
Royal College of Surgeons in Ireland, Dublin, Ireland.
Jimenez-Mateos EM
Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: evajimenez@rcsi.ie.

MeSH

AnimalsBiomarkersBrainHumansMicroRNAsNeurodegenerative Diseases

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28838542

Citation

Quinlan, Sean, et al. "MicroRNAs in Neurodegenerative Diseases." International Review of Cell and Molecular Biology, vol. 334, 2017, pp. 309-343.
Quinlan S, Kenny A, Medina M, et al. MicroRNAs in Neurodegenerative Diseases. Int Rev Cell Mol Biol. 2017;334:309-343.
Quinlan, S., Kenny, A., Medina, M., Engel, T., & Jimenez-Mateos, E. M. (2017). MicroRNAs in Neurodegenerative Diseases. International Review of Cell and Molecular Biology, 334, 309-343. https://doi.org/10.1016/bs.ircmb.2017.04.002
Quinlan S, et al. MicroRNAs in Neurodegenerative Diseases. Int Rev Cell Mol Biol. 2017;334:309-343. PubMed PMID: 28838542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs in Neurodegenerative Diseases. AU - Quinlan,Sean, AU - Kenny,Aidan, AU - Medina,Miguel, AU - Engel,Tobias, AU - Jimenez-Mateos,Eva M, Y1 - 2017/06/16/ PY - 2017/8/26/entrez PY - 2017/8/26/pubmed PY - 2018/5/1/medline KW - Alzheimer's disease KW - Biomarkers KW - Huntington's disease KW - MicroRNAs KW - Neurodegeneration KW - Parkinson's disease SP - 309 EP - 343 JF - International review of cell and molecular biology JO - Int Rev Cell Mol Biol VL - 334 N2 - MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain. MicroRNAs have been described as the main regulator of homeostasis in neurons, and their dysregulation results in pathological conditions in the brain. In this review, we will focus on the role of MicroRNAs as novel drug targets and biomarkers of the three main neurodegenerative disorders (Alzheimer's disease, Parkinson's diseases, and Huntington's disease) and their role in other neurological disorders including traumatic brain injury and status epilepticus. SN - 1937-6448 UR - https://www.unboundmedicine.com/medline/citation/28838542/MicroRNAs_in_Neurodegenerative_Diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1937-6448(17)30051-5 DB - PRIME DP - Unbound Medicine ER -