Inhibition by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C, of enzyme induction by glucocorticoid and of nuclear translocation of glucocorticoid-receptor complexes.Biochem Biophys Res Commun. 1987 Apr 14; 144(1):152-9.BB
Abstract
Induction of tyrosine aminotransferase by glucocorticoid in rat hepatocytes was inhibited concentration-dependently by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7), an inhibitor of protein kinase C, but not by N- [2-(methyl-amino)-ethyl]-5-isoquinolinesulfonamide dihydrochloride, an inhibitor of cyclic nucleotide dependent protein kinases. H-7 also inhibited the accumulation of glucocorticoid-receptor complexes in the nuclear fraction with associated accumulation of these complexes in the cytoplasmic fraction, but did not affect incorporation of glucocorticoid into hepatocytes. These results indicate that protein kinase C may be essential in translocation of glucocorticoid-receptor complexes to the nuclei.
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
2883968
Citation
Kido, H, et al. "Inhibition By 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an Inhibitor of Protein Kinase C, of Enzyme Induction By Glucocorticoid and of Nuclear Translocation of Glucocorticoid-receptor Complexes." Biochemical and Biophysical Research Communications, vol. 144, no. 1, 1987, pp. 152-9.
Kido H, Fukusen N, Katunuma N. Inhibition by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C, of enzyme induction by glucocorticoid and of nuclear translocation of glucocorticoid-receptor complexes. Biochem Biophys Res Commun. 1987;144(1):152-9.
Kido, H., Fukusen, N., & Katunuma, N. (1987). Inhibition by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C, of enzyme induction by glucocorticoid and of nuclear translocation of glucocorticoid-receptor complexes. Biochemical and Biophysical Research Communications, 144(1), 152-9.
Kido H, Fukusen N, Katunuma N. Inhibition By 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an Inhibitor of Protein Kinase C, of Enzyme Induction By Glucocorticoid and of Nuclear Translocation of Glucocorticoid-receptor Complexes. Biochem Biophys Res Commun. 1987 Apr 14;144(1):152-9. PubMed PMID: 2883968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Inhibition by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C, of enzyme induction by glucocorticoid and of nuclear translocation of glucocorticoid-receptor complexes.
AU - Kido,H,
AU - Fukusen,N,
AU - Katunuma,N,
PY - 1987/4/14/pubmed
PY - 1987/4/14/medline
PY - 1987/4/14/entrez
SP - 152
EP - 9
JF - Biochemical and biophysical research communications
JO - Biochem Biophys Res Commun
VL - 144
IS - 1
N2 - Induction of tyrosine aminotransferase by glucocorticoid in rat hepatocytes was inhibited concentration-dependently by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7), an inhibitor of protein kinase C, but not by N- [2-(methyl-amino)-ethyl]-5-isoquinolinesulfonamide dihydrochloride, an inhibitor of cyclic nucleotide dependent protein kinases. H-7 also inhibited the accumulation of glucocorticoid-receptor complexes in the nuclear fraction with associated accumulation of these complexes in the cytoplasmic fraction, but did not affect incorporation of glucocorticoid into hepatocytes. These results indicate that protein kinase C may be essential in translocation of glucocorticoid-receptor complexes to the nuclei.
SN - 0006-291X
UR - https://www.unboundmedicine.com/medline/citation/2883968/Inhibition_by_1__5_isoquinolinesulfonyl__2_methylpiperazine_an_inhibitor_of_protein_kinase_C_of_enzyme_induction_by_glucocorticoid_and_of_nuclear_translocation_of_glucocorticoid_receptor_complexes_
DB - PRIME
DP - Unbound Medicine
ER -
