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Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures.
Eur J Pediatr. 2017 Oct; 176(10):1355-1363.EJ

Abstract

Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess vertebral fracture (VF) rate in children and adolescents with IBD. Seventy patients with IBD with a median age of 13.8 years were included. The BMD and geometric parameters of the non-dominant tibia were assessed using pQCT. Dynamic muscle functions were evaluated using jumping mechanography. VFs were assessed according to the semiquantitative standardized method by Genant. The muscle functions adjusted for the patients' weight did not differ from the reference population. A low trabecular BMD (Z-score - 1.6; p < 0.001) and cortical thickness (Z-score - 0.7; p < 0.001) were found in children and adolescents with IBD. Conversely, an increased cortical BMD (Z-score 1.1; p < 0.001) was noted. No significant association was found between the 25-OHD serum levels and the bone or muscle measurements. One patient with asymptomatic VF was identified.

CONCLUSION

IBD in childhood or adolescents affects bones but not muscles. Bone changes are independent of the 25-OHD serum level. A thoracolumbar spine X-ray should not be routinely recommended in children with IBD. What is Known: • Low bone mineral density and an increased fracture rate are the complications associated with IBD. • Bone strength and structural development is strongly dependent on skeletal muscle stimulation. What is New: • Children with IBD have altered bone density and geometry but normal dynamic muscle functions. • Thoracolumbar spine X-ray should be indicated on an individual basis in children with IBD.

Authors+Show Affiliations

Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic. ondrej.soucek@lfmotol.cuni.cz.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, 150 06, Prague 5, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28840427

Citation

Maratova, Klara, et al. "Musculoskeletal System in Children and Adolescents With Inflammatory Bowel Disease: Normal Muscle Force, Decreased Trabecular Bone Mineral Density and Low Prevalence of Vertebral Fractures." European Journal of Pediatrics, vol. 176, no. 10, 2017, pp. 1355-1363.
Maratova K, Hradsky O, Matyskova J, et al. Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures. Eur J Pediatr. 2017;176(10):1355-1363.
Maratova, K., Hradsky, O., Matyskova, J., Copova, I., Soucek, O., Sumnik, Z., & Bronsky, J. (2017). Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures. European Journal of Pediatrics, 176(10), 1355-1363. https://doi.org/10.1007/s00431-017-2988-7
Maratova K, et al. Musculoskeletal System in Children and Adolescents With Inflammatory Bowel Disease: Normal Muscle Force, Decreased Trabecular Bone Mineral Density and Low Prevalence of Vertebral Fractures. Eur J Pediatr. 2017;176(10):1355-1363. PubMed PMID: 28840427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures. AU - Maratova,Klara, AU - Hradsky,Ondrej, AU - Matyskova,Jana, AU - Copova,Ivana, AU - Soucek,Ondrej, AU - Sumnik,Zdenek, AU - Bronsky,Jiri, Y1 - 2017/08/24/ PY - 2017/06/08/received PY - 2017/08/03/accepted PY - 2017/07/21/revised PY - 2017/8/26/pubmed PY - 2018/6/2/medline PY - 2017/8/26/entrez KW - Bone strength KW - Inflammatory bowel disease KW - Mechanography KW - Muscle functions KW - Peripheral quantitative computed tomography KW - Vitamin D SP - 1355 EP - 1363 JF - European journal of pediatrics JO - Eur J Pediatr VL - 176 IS - 10 N2 - : Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess vertebral fracture (VF) rate in children and adolescents with IBD. Seventy patients with IBD with a median age of 13.8 years were included. The BMD and geometric parameters of the non-dominant tibia were assessed using pQCT. Dynamic muscle functions were evaluated using jumping mechanography. VFs were assessed according to the semiquantitative standardized method by Genant. The muscle functions adjusted for the patients' weight did not differ from the reference population. A low trabecular BMD (Z-score - 1.6; p < 0.001) and cortical thickness (Z-score - 0.7; p < 0.001) were found in children and adolescents with IBD. Conversely, an increased cortical BMD (Z-score 1.1; p < 0.001) was noted. No significant association was found between the 25-OHD serum levels and the bone or muscle measurements. One patient with asymptomatic VF was identified. CONCLUSION: IBD in childhood or adolescents affects bones but not muscles. Bone changes are independent of the 25-OHD serum level. A thoracolumbar spine X-ray should not be routinely recommended in children with IBD. What is Known: • Low bone mineral density and an increased fracture rate are the complications associated with IBD. • Bone strength and structural development is strongly dependent on skeletal muscle stimulation. What is New: • Children with IBD have altered bone density and geometry but normal dynamic muscle functions. • Thoracolumbar spine X-ray should be indicated on an individual basis in children with IBD. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/28840427/Musculoskeletal_system_in_children_and_adolescents_with_inflammatory_bowel_disease:_normal_muscle_force_decreased_trabecular_bone_mineral_density_and_low_prevalence_of_vertebral_fractures_ L2 - https://dx.doi.org/10.1007/s00431-017-2988-7 DB - PRIME DP - Unbound Medicine ER -