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Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly.
Endocrinol Jpn. 1986 Dec; 33(6):743-9.EJ

Abstract

The effect of a long-acting somatostatin analogue SMS 201-995 on GH secretion was investigated. Eleven acromegalic patients received a single dose of 50 micrograms SMS 201-995 administered subcutaneously, and plasma GH, IGF-I, GRF, TSH, IRI and blood glucose were determined at regular intervals. Nine of 11 patients had elevated basal plasma GH levels above 5 ng/ml. In all patients, plasma GH levels fell immediately from 39.5 +/- 17.3 ng/ml (mean +/- SEM) to 4.3 +/- 1.6 ng/ml (P less than 0.05) with a maximal inhibition of 82.9 +/- 3.3% of the basal levels and the suppression persisted for about 6 h of the observation period. IGF-I and GRF levels were not apparently altered. TSH and IRI levels also rapidly fell. Blood glucose levels fell slightly by 0.5 h. Ten of 11 patients had pain at injection sites. Except for this, no side effects were observed. Our results show that the new somatostatin analogue SMS 201-995 may inhibit GH hypersecretion in acromegalic patients for significant periods, suggesting that this agent can be a useful clinical tool for the treatment of acromegaly.

Authors

Horikawa R
No affiliation info available
Takano K
No affiliation info available
Hizuka N
No affiliation info available
Asakawa K
No affiliation info available
Shibasaki T
No affiliation info available
Masuda A
No affiliation info available
Shizume K
No affiliation info available

MeSH

AcromegalyAdultBlood GlucoseFemaleGrowth HormoneHumansInsulinInsulin SecretionInsulin-Like Growth Factor IMaleMiddle AgedOctreotideSecretory RateSomatostatinThyrotropinTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2884093

Citation

Horikawa, R, et al. "Effect of a Single Administration of Somatostatin Analogue (SMS 201-995) On GH, TSH and Insulin Secretion in Patients With Acromegaly." Endocrinologia Japonica, vol. 33, no. 6, 1986, pp. 743-9.
Horikawa R, Takano K, Hizuka N, et al. Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly. Endocrinol Jpn. 1986;33(6):743-9.
Horikawa, R., Takano, K., Hizuka, N., Asakawa, K., Shibasaki, T., Masuda, A., & Shizume, K. (1986). Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly. Endocrinologia Japonica, 33(6), 743-9.
Horikawa R, et al. Effect of a Single Administration of Somatostatin Analogue (SMS 201-995) On GH, TSH and Insulin Secretion in Patients With Acromegaly. Endocrinol Jpn. 1986;33(6):743-9. PubMed PMID: 2884093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly. AU - Horikawa,R, AU - Takano,K, AU - Hizuka,N, AU - Asakawa,K, AU - Shibasaki,T, AU - Masuda,A, AU - Shizume,K, PY - 1986/12/1/pubmed PY - 1986/12/1/medline PY - 1986/12/1/entrez SP - 743 EP - 9 JF - Endocrinologia japonica JO - Endocrinol Jpn VL - 33 IS - 6 N2 - The effect of a long-acting somatostatin analogue SMS 201-995 on GH secretion was investigated. Eleven acromegalic patients received a single dose of 50 micrograms SMS 201-995 administered subcutaneously, and plasma GH, IGF-I, GRF, TSH, IRI and blood glucose were determined at regular intervals. Nine of 11 patients had elevated basal plasma GH levels above 5 ng/ml. In all patients, plasma GH levels fell immediately from 39.5 +/- 17.3 ng/ml (mean +/- SEM) to 4.3 +/- 1.6 ng/ml (P less than 0.05) with a maximal inhibition of 82.9 +/- 3.3% of the basal levels and the suppression persisted for about 6 h of the observation period. IGF-I and GRF levels were not apparently altered. TSH and IRI levels also rapidly fell. Blood glucose levels fell slightly by 0.5 h. Ten of 11 patients had pain at injection sites. Except for this, no side effects were observed. Our results show that the new somatostatin analogue SMS 201-995 may inhibit GH hypersecretion in acromegalic patients for significant periods, suggesting that this agent can be a useful clinical tool for the treatment of acromegaly. SN - 0013-7219 UR - https://www.unboundmedicine.com/medline/citation/2884093/Effect_of_a_single_administration_of_somatostatin_analogue__SMS_201_995__on_GH_TSH_and_insulin_secretion_in_patients_with_acromegaly_ DB - PRIME DP - Unbound Medicine ER -