TY - JOUR T1 - Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats. AU - Refaie,Marwa M M, AU - El-Hussieny,Maram, Y1 - 2017/09/12/ PY - 2017/06/14/received PY - 2017/08/08/revised PY - 2017/08/09/accepted PY - 2017/8/28/pubmed PY - 2018/6/19/medline PY - 2017/8/28/entrez KW - Cervical hyperkeratosis KW - Diacerein KW - Estradiol benzoate KW - Interleukin-1b SP - 223 EP - 229 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 95 N2 - Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervical hyperkeratosis induced by intramuscular injection of Estradiol benzoate (60μg/100g) 3 times per week for 4 weeks. We measured the serum levels of total cholesterol, uterine weights, uterine tissue malondialdehyde, total nitrites, superoxide dismutase activity, caspase-3, interleukin-1b immunoexpression and histopathology. Our results showed that Estradiol benzoate succeeded to induce cervical hyperkeratosis which was detected by typical histopathological changes. In addition; there was significant reduction in superoxide dismutase levels and caspase-3 immunoexpression but significant increase in serum total cholesterol, malondialdehyde, total nitrites and interleukin-1b immunoexpression. Diacerein could improve all measured parameters to normal levels. It markedly prevented cervical hyperkeratosis through its anti-inflammatory (IL-1b receptor inhibitor), antioxidant and anti-apoptotic effects. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28843910/Diacerein_inhibits_Estradiol_benzoate_induced_cervical_hyperkeratosis_in_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)32876-7 DB - PRIME DP - Unbound Medicine ER -