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Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats.
Biomed Pharmacother. 2017 Nov; 95:223-229.BP

Abstract

Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervical hyperkeratosis induced by intramuscular injection of Estradiol benzoate (60μg/100g) 3 times per week for 4 weeks. We measured the serum levels of total cholesterol, uterine weights, uterine tissue malondialdehyde, total nitrites, superoxide dismutase activity, caspase-3, interleukin-1b immunoexpression and histopathology. Our results showed that Estradiol benzoate succeeded to induce cervical hyperkeratosis which was detected by typical histopathological changes. In addition; there was significant reduction in superoxide dismutase levels and caspase-3 immunoexpression but significant increase in serum total cholesterol, malondialdehyde, total nitrites and interleukin-1b immunoexpression. Diacerein could improve all measured parameters to normal levels. It markedly prevented cervical hyperkeratosis through its anti-inflammatory (IL-1b receptor inhibitor), antioxidant and anti-apoptotic effects.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, El-Minia University, El-Minia, Egypt. Electronic address: marwamonier@yahoo.com.Department of Pathology, Faculty of Medicine, El-Minia University, El-Minia, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28843910

Citation

Refaie, Marwa M M., and Maram El-Hussieny. "Diacerein Inhibits Estradiol-benzoate Induced Cervical Hyperkeratosis in Female Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 95, 2017, pp. 223-229.
Refaie MMM, El-Hussieny M. Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats. Biomed Pharmacother. 2017;95:223-229.
Refaie, M. M. M., & El-Hussieny, M. (2017). Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 95, 223-229. https://doi.org/10.1016/j.biopha.2017.08.053
Refaie MMM, El-Hussieny M. Diacerein Inhibits Estradiol-benzoate Induced Cervical Hyperkeratosis in Female Rats. Biomed Pharmacother. 2017;95:223-229. PubMed PMID: 28843910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats. AU - Refaie,Marwa M M, AU - El-Hussieny,Maram, Y1 - 2017/09/12/ PY - 2017/06/14/received PY - 2017/08/08/revised PY - 2017/08/09/accepted PY - 2017/8/28/pubmed PY - 2018/6/19/medline PY - 2017/8/28/entrez KW - Cervical hyperkeratosis KW - Diacerein KW - Estradiol benzoate KW - Interleukin-1b SP - 223 EP - 229 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 95 N2 - Cervical hyperkeratosis is a common gynecological lesion and usually caused by inflammation or trauma. We investigated the effect of Diacerein on Estradiol benzoate-induced cervical hyperkeratosis. Diacerein (50mg/kg/day) was given orally to rats for 4 weeks in the presence or absence of cervical hyperkeratosis induced by intramuscular injection of Estradiol benzoate (60μg/100g) 3 times per week for 4 weeks. We measured the serum levels of total cholesterol, uterine weights, uterine tissue malondialdehyde, total nitrites, superoxide dismutase activity, caspase-3, interleukin-1b immunoexpression and histopathology. Our results showed that Estradiol benzoate succeeded to induce cervical hyperkeratosis which was detected by typical histopathological changes. In addition; there was significant reduction in superoxide dismutase levels and caspase-3 immunoexpression but significant increase in serum total cholesterol, malondialdehyde, total nitrites and interleukin-1b immunoexpression. Diacerein could improve all measured parameters to normal levels. It markedly prevented cervical hyperkeratosis through its anti-inflammatory (IL-1b receptor inhibitor), antioxidant and anti-apoptotic effects. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/28843910/Diacerein_inhibits_Estradiol_benzoate_induced_cervical_hyperkeratosis_in_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)32876-7 DB - PRIME DP - Unbound Medicine ER -