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Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies.
BMJ Open. 2017 Aug 27; 7(8):e016404.BO

Abstract

OBJECTIVE

To determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA).

METHODS

A comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model.

RESULTS

A total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 (95% CI 1.138 to 2.216; p<0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.

CONCLUSION

This meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA.

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Authors+Show Affiliations

Chen Y
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Zhu B
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China.
Wu X
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China.
Li S
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Tao F
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, China.

MeSH

Dietary SupplementsFemaleHumansInfant, NewbornInfant, Small for Gestational AgeMaternal Nutritional Physiological PhenomenaOdds RatioPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsVitamin DVitamin D DeficiencyVitamins

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

28844987

Citation

Chen, Yao, et al. "Association Between Maternal Vitamin D Deficiency and Small for Gestational Age: Evidence From a Meta-analysis of Prospective Cohort Studies." BMJ Open, vol. 7, no. 8, 2017, pp. e016404.
Chen Y, Zhu B, Wu X, et al. Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies. BMJ Open. 2017;7(8):e016404.
Chen, Y., Zhu, B., Wu, X., Li, S., & Tao, F. (2017). Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies. BMJ Open, 7(8), e016404. https://doi.org/10.1136/bmjopen-2017-016404
Chen Y, et al. Association Between Maternal Vitamin D Deficiency and Small for Gestational Age: Evidence From a Meta-analysis of Prospective Cohort Studies. BMJ Open. 2017 Aug 27;7(8):e016404. PubMed PMID: 28844987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies. AU - Chen,Yao, AU - Zhu,Beibei, AU - Wu,Xiaoyan, AU - Li,Si, AU - Tao,Fangbiao, Y1 - 2017/08/27/ PY - 2017/8/29/entrez PY - 2017/8/29/pubmed PY - 2018/7/26/medline KW - cohort study KW - meta-analysis KW - small for gestational age KW - vitamin D SP - e016404 EP - e016404 JF - BMJ open JO - BMJ Open VL - 7 IS - 8 N2 - OBJECTIVE: To determine whether maternal vitamin D deficiency during pregnancy is associated with small for gestational age (SGA). METHODS: A comprehensive literature search of PubMed, the Cochrane Library, Embase, and the Elsevier ScienceDirect library was conducted to identify relevant articles reporting prospective cohort studies in English, with the last report included published in February 2017. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to evaluate the correlation in a random effects model. RESULTS: A total of 13 cohort studies were included in this meta-analysis with a sample of 28 285 individuals from seven countries. The pooled overall OR for babies born SGA was 1.588 (95% CI 1.138 to 2.216; p<0.01) for women with vitamin D deficiency. The prevalence of vitamin D deficiency during pregnancy varied from 13.2% to 77.3%. Subgroup analyses identified no significant differences in the association between vitamin D deficiency and SGA based on study quality, gestational week during which blood sampling was performed, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D. CONCLUSION: This meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/28844987/Association_between_maternal_vitamin_D_deficiency_and_small_for_gestational_age:_evidence_from_a_meta_analysis_of_prospective_cohort_studies_ L2 - https://bmjopen.bmj.com/lookup/pmidlookup?view=long&amp;pmid=28844987 DB - PRIME DP - Unbound Medicine ER -