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Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season.
Hum Vaccin Immunother. 2017 10 03; 13(10):2379-2384.HV

Abstract

Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, there is limited information regarding the preventive effect of influenza vaccination for the same season in China, in which H3N2 viruses belonging to the 3C.3a clade predominated. Through influenza virological surveillance in Beijing, China during the 2014/15 season, we estimated the influenza VE against medically attended influenza-like illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative design, and the effect of prior vaccination on current vaccination was examined. In total, 9297 patients with ILI were enrolled in this study. Among them, 3434 (36.9%) tested positive for influenza viruses: 2167 (63.1%) for A(H3N2), 1261 (36.7%) for influenza B, and 3 (0.1%) for A(H1N1)pdm09. The adjusted VE was estimated as -25% (95% CI: -70%, 8%) against A(H3N2) and -8% (95% CI: -50%, 23%) against B, with an overall VE of -18% (95% CI: -49%, 6%). The overall VE estimate for patients who received 2014/15 vaccination only was -12% (-57%, 20%), while VE for patients who received both 2013/14 and 2014/15 vaccinations was -27% (-72%, 7%). There was no evidence that the influenza vaccine protected vaccinees against medically attended influenza in Beijing, China during the 2014/15 season.

Authors+Show Affiliations

a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China. c School of Public Health, Capital Medical University , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China.a Beijing Center for Disease Prevention and Control , Beijing , China. b Beijing Research Center for Preventive Medicine , Beijing , China. c School of Public Health, Capital Medical University , Beijing , China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28846480

Citation

Ma, Chunna, et al. "Influenza Vaccine Effectiveness Against Medically Attended Influenza Illness in Beijing, China, 2014/15 Season." Human Vaccines & Immunotherapeutics, vol. 13, no. 10, 2017, pp. 2379-2384.
Ma C, Pan Y, Zhang L, et al. Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season. Hum Vaccin Immunother. 2017;13(10):2379-2384.
Ma, C., Pan, Y., Zhang, L., Zhang, Y., Wu, S., Sun, Y., Duan, W., Zhang, M., Wang, Q., & Yang, P. (2017). Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season. Human Vaccines & Immunotherapeutics, 13(10), 2379-2384. https://doi.org/10.1080/21645515.2017.1359364
Ma C, et al. Influenza Vaccine Effectiveness Against Medically Attended Influenza Illness in Beijing, China, 2014/15 Season. Hum Vaccin Immunother. 2017 10 3;13(10):2379-2384. PubMed PMID: 28846480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season. AU - Ma,Chunna, AU - Pan,Yang, AU - Zhang,Li, AU - Zhang,Yi, AU - Wu,Shuangsheng, AU - Sun,Ying, AU - Duan,Wei, AU - Zhang,Man, AU - Wang,Quanyi, AU - Yang,Peng, PY - 2017/8/29/pubmed PY - 2018/6/12/medline PY - 2017/8/29/entrez KW - China KW - influenza KW - influenza-like illness KW - test-negative design KW - vaccine effectiveness SP - 2379 EP - 2384 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 13 IS - 10 N2 - Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, there is limited information regarding the preventive effect of influenza vaccination for the same season in China, in which H3N2 viruses belonging to the 3C.3a clade predominated. Through influenza virological surveillance in Beijing, China during the 2014/15 season, we estimated the influenza VE against medically attended influenza-like illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative design, and the effect of prior vaccination on current vaccination was examined. In total, 9297 patients with ILI were enrolled in this study. Among them, 3434 (36.9%) tested positive for influenza viruses: 2167 (63.1%) for A(H3N2), 1261 (36.7%) for influenza B, and 3 (0.1%) for A(H1N1)pdm09. The adjusted VE was estimated as -25% (95% CI: -70%, 8%) against A(H3N2) and -8% (95% CI: -50%, 23%) against B, with an overall VE of -18% (95% CI: -49%, 6%). The overall VE estimate for patients who received 2014/15 vaccination only was -12% (-57%, 20%), while VE for patients who received both 2013/14 and 2014/15 vaccinations was -27% (-72%, 7%). There was no evidence that the influenza vaccine protected vaccinees against medically attended influenza in Beijing, China during the 2014/15 season. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/28846480/Influenza_vaccine_effectiveness_against_medically_attended_influenza_illness_in_Beijing_China_2014/15_season_ L2 - https://www.tandfonline.com/doi/full/10.1080/21645515.2017.1359364 DB - PRIME DP - Unbound Medicine ER -