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Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis.
Nutrients. 2017 Aug 26; 9(9)N

Abstract

Irritable bowel syndrome (IBS) affects 7-15% of the general population. A recently devised dietary approach consists of restricting foods with highly fermentable oligo-, di-, and monosaccharides, and polyols (FODMAPs), which can trigger and/or exacerbate IBS symptoms. The aim of this study is to use meta-analysis to provide an update on the randomised control trials (RCTs) and cohort studies, and examine them separately in relation to diet type. Papers were selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. Cohen's d and odds ratios were used as a measure of effect size for RCTs. A random effects model was used to account for different sources of variation among studies. Heterogeneity was assessed using Q statistics, I², Tau, and Tau². Publication bias was analysed and represented by a funnel plot, and funnel plot symmetry was assessed with Egger's test. The results showed that in the RCTs, the patients receiving a low-FODMAP diet experienced a statistically significant pain and bloating reduction compared with those receiving a traditional diet; as regards to stool consistency, there was no significant difference between treatments. A significant reduction in abdominal pain and bloating were described by patients receiving a low-FODMAP diet compared with those receiving a high-FODMAP diet. In cohort studies, pain and bloating were significantly reduced after treatment compared with the baseline diet. We conclude that there is evidence that a low-FODMAP diet could have a favourable impact on IBS symptoms, especially abdominal pain and bloating. However, it remains to be demonstrated whether a low-FODMAP diet is superior to conventional IBS diets, especially in the long term.

Authors+Show Affiliations

Department of Life, Health and Environmental Sciences, Epidemiology and Biostatistics Unit, University of L'Aquila, 67100 L'Aquila, Italy. emma.altobelli@cc.univaq.it.Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, 67100 L'Aquila, Italy. valerio.delnegro@gmail.com.Department of Life, Health and Environmental Sciences, Epidemiology and Biostatistics Unit, University of L'Aquila, 67100 L'Aquila, Italy. paolomatteoangeletti@gmail.com.Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, 67100 L'Aquila, Italy. giovanni.latella@cc.univaq.it.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

28846594

Citation

Altobelli, Emma, et al. "Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: a Meta-Analysis." Nutrients, vol. 9, no. 9, 2017.
Altobelli E, Del Negro V, Angeletti PM, et al. Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis. Nutrients. 2017;9(9).
Altobelli, E., Del Negro, V., Angeletti, P. M., & Latella, G. (2017). Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis. Nutrients, 9(9). https://doi.org/10.3390/nu9090940
Altobelli E, et al. Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: a Meta-Analysis. Nutrients. 2017 Aug 26;9(9) PubMed PMID: 28846594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis. AU - Altobelli,Emma, AU - Del Negro,Valerio, AU - Angeletti,Paolo Matteo, AU - Latella,Giovanni, Y1 - 2017/08/26/ PY - 2017/06/15/received PY - 2017/08/21/revised PY - 2017/08/22/accepted PY - 2017/8/29/entrez PY - 2017/8/29/pubmed PY - 2018/5/10/medline KW - epidemiology KW - irritable bowel syndrome KW - meta-analysis KW - nutrition JF - Nutrients JO - Nutrients VL - 9 IS - 9 N2 - Irritable bowel syndrome (IBS) affects 7-15% of the general population. A recently devised dietary approach consists of restricting foods with highly fermentable oligo-, di-, and monosaccharides, and polyols (FODMAPs), which can trigger and/or exacerbate IBS symptoms. The aim of this study is to use meta-analysis to provide an update on the randomised control trials (RCTs) and cohort studies, and examine them separately in relation to diet type. Papers were selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. Cohen's d and odds ratios were used as a measure of effect size for RCTs. A random effects model was used to account for different sources of variation among studies. Heterogeneity was assessed using Q statistics, I², Tau, and Tau². Publication bias was analysed and represented by a funnel plot, and funnel plot symmetry was assessed with Egger's test. The results showed that in the RCTs, the patients receiving a low-FODMAP diet experienced a statistically significant pain and bloating reduction compared with those receiving a traditional diet; as regards to stool consistency, there was no significant difference between treatments. A significant reduction in abdominal pain and bloating were described by patients receiving a low-FODMAP diet compared with those receiving a high-FODMAP diet. In cohort studies, pain and bloating were significantly reduced after treatment compared with the baseline diet. We conclude that there is evidence that a low-FODMAP diet could have a favourable impact on IBS symptoms, especially abdominal pain and bloating. However, it remains to be demonstrated whether a low-FODMAP diet is superior to conventional IBS diets, especially in the long term. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28846594/Low_FODMAP_Diet_Improves_Irritable_Bowel_Syndrome_Symptoms:_A_Meta_Analysis_ L2 - https://www.mdpi.com/resolver?pii=nu9090940 DB - PRIME DP - Unbound Medicine ER -