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Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice.
Cancer Prev Res (Phila) 2017; 10(11):660-670CP

Abstract

Caloric restriction (CR) and endurance exercise elicit wide-ranging health benefits including reduced risk of select cancers. In addition, diet composition influences oncogenesis, although its interactions with exercise and CR are not well understood. Therefore, to investigate the potential interactions between diet and lifestyle interventions on liver tumorigenesis, the carcinogen diethylnitrosamine was administered to 72 male C57Bl/6 mice that were subsequently fed diets enriched with lard (CTL) or olive oil and were further stratified to voluntary wheel running (Ex) or 30% CR for 49 weeks. Although Ex and diet composition did not influence liver oncogenesis, CR prevented hepatic tumor formation. In addition, CR reduced steatosis, hepatocyte ballooning, inflammation, and immune cell infiltration, all of which are hallmarks in the progression of nonalcoholic fatty liver disease to liver tumorigenesis. RNA sequencing of nontransformed liver tissues from CR mice revealed changes in metabolic pathways and reduced inflammation, cytokine production, stellate cell activation and migration, and genes associated with liver injury and oncogenesis. These data demonstrate that CR protects against steatosis, liver inflammation, and liver injury and is a robust deterrent of carcinogen-induced hepatic oncogenesis. Cancer Prev Res; 10(11); 660-70. ©2017 AACR.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, Minneapolis, Minnesota.Department of Pathology and Laboratory Medicine. Veterans Administration Medical Center. Minneapolis, Minnesota.Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota. dmashek@umn.edu. Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28847977

Citation

Ploeger, Jonathan M., et al. "Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice." Cancer Prevention Research (Philadelphia, Pa.), vol. 10, no. 11, 2017, pp. 660-670.
Ploeger JM, Manivel JC, Boatner LN, et al. Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice. Cancer Prev Res (Phila). 2017;10(11):660-670.
Ploeger, J. M., Manivel, J. C., Boatner, L. N., & Mashek, D. G. (2017). Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice. Cancer Prevention Research (Philadelphia, Pa.), 10(11), pp. 660-670. doi:10.1158/1940-6207.CAPR-17-0174.
Ploeger JM, et al. Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice. Cancer Prev Res (Phila). 2017;10(11):660-670. PubMed PMID: 28847977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice. AU - Ploeger,Jonathan M, AU - Manivel,Juan C, AU - Boatner,Lauren N, AU - Mashek,Douglas G, Y1 - 2017/08/28/ PY - 2017/06/06/received PY - 2017/07/27/revised PY - 2017/08/22/accepted PY - 2017/8/30/pubmed PY - 2018/6/22/medline PY - 2017/8/30/entrez SP - 660 EP - 670 JF - Cancer prevention research (Philadelphia, Pa.) JO - Cancer Prev Res (Phila) VL - 10 IS - 11 N2 - Caloric restriction (CR) and endurance exercise elicit wide-ranging health benefits including reduced risk of select cancers. In addition, diet composition influences oncogenesis, although its interactions with exercise and CR are not well understood. Therefore, to investigate the potential interactions between diet and lifestyle interventions on liver tumorigenesis, the carcinogen diethylnitrosamine was administered to 72 male C57Bl/6 mice that were subsequently fed diets enriched with lard (CTL) or olive oil and were further stratified to voluntary wheel running (Ex) or 30% CR for 49 weeks. Although Ex and diet composition did not influence liver oncogenesis, CR prevented hepatic tumor formation. In addition, CR reduced steatosis, hepatocyte ballooning, inflammation, and immune cell infiltration, all of which are hallmarks in the progression of nonalcoholic fatty liver disease to liver tumorigenesis. RNA sequencing of nontransformed liver tissues from CR mice revealed changes in metabolic pathways and reduced inflammation, cytokine production, stellate cell activation and migration, and genes associated with liver injury and oncogenesis. These data demonstrate that CR protects against steatosis, liver inflammation, and liver injury and is a robust deterrent of carcinogen-induced hepatic oncogenesis. Cancer Prev Res; 10(11); 660-70. ©2017 AACR. SN - 1940-6215 UR - https://www.unboundmedicine.com/medline/citation/28847977/Caloric_Restriction_Prevents_Carcinogen_Initiated_Liver_Tumorigenesis_in_Mice_ L2 - http://cancerpreventionresearch.aacrjournals.org/cgi/pmidlookup?view=long&pmid=28847977 DB - PRIME DP - Unbound Medicine ER -