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Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles.
Int J Mol Med. 2017 Oct; 40(4):1194-1200.IJ

Abstract

It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.

Authors+Show Affiliations

Amorepacific R&D Center, Yongin-si, Gyeonggi-do 446-729, Republic of Korea.Amorepacific R&D Center, Yongin-si, Gyeonggi-do 446-729, Republic of Korea.Amorepacific R&D Center, Yongin-si, Gyeonggi-do 446-729, Republic of Korea.Department of Dermatology, Dankook Medical College, Cheonan, Chungcheongnam-do 31116, Republic of Korea.Amorepacific R&D Center, Yongin-si, Gyeonggi-do 446-729, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28849028

Citation

Lee, Yonghee, et al. "Panax Ginseng Extract Antagonizes the Effect of DKK‑1-induced Catagen-like Changes of Hair Follicles." International Journal of Molecular Medicine, vol. 40, no. 4, 2017, pp. 1194-1200.
Lee Y, Kim SN, Hong YD, et al. Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. Int J Mol Med. 2017;40(4):1194-1200.
Lee, Y., Kim, S. N., Hong, Y. D., Park, B. C., & Na, Y. (2017). Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. International Journal of Molecular Medicine, 40(4), 1194-1200. https://doi.org/10.3892/ijmm.2017.3107
Lee Y, et al. Panax Ginseng Extract Antagonizes the Effect of DKK‑1-induced Catagen-like Changes of Hair Follicles. Int J Mol Med. 2017;40(4):1194-1200. PubMed PMID: 28849028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Panax ginseng extract antagonizes the effect of DKK‑1-induced catagen-like changes of hair follicles. AU - Lee,Yonghee, AU - Kim,Su Na, AU - Hong,Yong Deog, AU - Park,Byung Cheol, AU - Na,Yongjoo, Y1 - 2017/08/25/ PY - 2017/01/03/received PY - 2017/08/11/accepted PY - 2017/8/30/pubmed PY - 2018/5/16/medline PY - 2017/8/30/entrez SP - 1194 EP - 1200 JF - International journal of molecular medicine JO - Int J Mol Med VL - 40 IS - 4 N2 - It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/28849028/Panax_ginseng_extract_antagonizes_the_effect_of_DKK‑1_induced_catagen_like_changes_of_hair_follicles_ DB - PRIME DP - Unbound Medicine ER -