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The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study.
Sci Rep 2017; 7(1):9825SR

Abstract

Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. OCT images were obtained in 103 highly myopic eyes (≤-6.00 diopters) and 227 normal eyes. The mean SFCT in highly myopic eyes was 110.6 ± 85.2 μm (range, 3 to 395 μm). The SFCT of high myopia without posterior scleral staphyloma(55 eyes) was 157.79 ± 85.18 μm, which was significantly greater than that (54.94 ± 49.96 μm) of high myopia with posterior scleral staphyloma (48 eyes) (P < 0.001). In multivariate analysis, posterior scleral staphyloma was the most important factor of choroidal thinning in high myopia (F = 22.63; P < 0.001), then age (F = 19.14; P < 0.001), axial length (F = 17.37; P < 0.001) and gender (F = 17.31; P < 0.001). The SFCT in highly myopic eyes is very thin and undergoes further thinning with increasing age and axial length (refractive error). Posterior staphyloma formation was a key factor in choroidal thinning in highly myopic eyes and to be a good indicator for risk management of choroidal thinning. Abnormalities of the choroid may play a role in the pathogenesis of myopic degeneration.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Department of Ophthalmology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. honghexili@163.com.Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28852194

Citation

Zhou, Ling Xiao, et al. "The Relationship Between Scleral Staphyloma and Choroidal Thinning in Highly Myopic Eyes: the Beijing Eye Study." Scientific Reports, vol. 7, no. 1, 2017, p. 9825.
Zhou LX, Shao L, Xu L, et al. The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. Sci Rep. 2017;7(1):9825.
Zhou, L. X., Shao, L., Xu, L., Wei, W. B., Wang, Y. X., & You, Q. S. (2017). The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. Scientific Reports, 7(1), p. 9825. doi:10.1038/s41598-017-10660-z.
Zhou LX, et al. The Relationship Between Scleral Staphyloma and Choroidal Thinning in Highly Myopic Eyes: the Beijing Eye Study. Sci Rep. 2017 08 29;7(1):9825. PubMed PMID: 28852194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between scleral staphyloma and choroidal thinning in highly myopic eyes: The Beijing Eye Study. AU - Zhou,Ling Xiao, AU - Shao,Lei, AU - Xu,Liang, AU - Wei,Wen Bin, AU - Wang,Ya Xing, AU - You,Qi Sheng, Y1 - 2017/08/29/ PY - 2017/04/26/received PY - 2017/08/14/accepted PY - 2017/8/31/entrez PY - 2017/8/31/pubmed PY - 2019/4/24/medline SP - 9825 EP - 9825 JF - Scientific reports JO - Sci Rep VL - 7 IS - 1 N2 - Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. OCT images were obtained in 103 highly myopic eyes (≤-6.00 diopters) and 227 normal eyes. The mean SFCT in highly myopic eyes was 110.6 ± 85.2 μm (range, 3 to 395 μm). The SFCT of high myopia without posterior scleral staphyloma(55 eyes) was 157.79 ± 85.18 μm, which was significantly greater than that (54.94 ± 49.96 μm) of high myopia with posterior scleral staphyloma (48 eyes) (P < 0.001). In multivariate analysis, posterior scleral staphyloma was the most important factor of choroidal thinning in high myopia (F = 22.63; P < 0.001), then age (F = 19.14; P < 0.001), axial length (F = 17.37; P < 0.001) and gender (F = 17.31; P < 0.001). The SFCT in highly myopic eyes is very thin and undergoes further thinning with increasing age and axial length (refractive error). Posterior staphyloma formation was a key factor in choroidal thinning in highly myopic eyes and to be a good indicator for risk management of choroidal thinning. Abnormalities of the choroid may play a role in the pathogenesis of myopic degeneration. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28852194/The_relationship_between_scleral_staphyloma_and_choroidal_thinning_in_highly_myopic_eyes:_The_Beijing_Eye_Study_ L2 - http://dx.doi.org/10.1038/s41598-017-10660-z DB - PRIME DP - Unbound Medicine ER -