Tags

Type your tag names separated by a space and hit enter

Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis.
Sci Rep. 2017 08 30; 7(1):9968.SR

Abstract

Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD) for several decades, and disturbed mitochondrial biogenesis (mitobiogenesis) was recently found to be a common phenomenon in PD. Baicalein, a major bioactive flavone of Scutellaria baicalensis Georgi, exerted neuroprotective effects in several experimental PD models. However, the effects of baicalein in rotenone-induced PD rats and the possible mechanisms remain poorly understood. In this study, we evaluated the therapeutic effects of baicalein and explored its mechanism of action in rotenone-induced PD models. The results indicated that behavioural impairments and the depletion of dopaminergic neurons induced by rotenone were attenuated by baicalein. Furthermore, in rotenone-induced parkinsonian rats, baicalein treatment effectively restored mitochondrial function and improved mitobiogenesis, as determined by measuring the mitochondrial density and key regulators involved in mitobiogenesis. Additionally, we confirmed that baicalein enhanced mitobiogenesis through the cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3β (GSK-3β) pathways in rotenone-treated SH-SY5Y cells. Moreover, we demonstrated that the cytoprotective effects of baicalein could be attenuated by the mitobiogenesis inhibitor chloramphenicol as well as CREB siRNA transfection. Overall, our results suggested that baicalein partially enhanced mitobiogenesis to restore mitochondrial function, thus exerting therapeutic effects in rotenone-induced PD models.

Links

PMC Free PDF
PMC Free Full Text

Authors+Show Affiliations

Zhang X
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China.
Du L
School of Biomedical Science, The Chinese University of Hong Kong, Hong Kong, S.A.R., China.
Zhang W
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China.
Yang Y
Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Zhou Q
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China.
Du G
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China. dugh@imm.ac.cn.

MeSH

AnimalsDisease Models, AnimalFlavanonesMitochondriaNeuroprotective AgentsOrganelle BiogenesisParkinson DiseaseParkinson Disease, SecondaryRatsRotenoneTherapeutic Uses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28855526

Citation

Zhang, Xue, et al. "Therapeutic Effects of Baicalein On Rotenone-induced Parkinson's Disease Through Protecting Mitochondrial Function and Biogenesis." Scientific Reports, vol. 7, no. 1, 2017, p. 9968.
Zhang X, Du L, Zhang W, et al. Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis. Sci Rep. 2017;7(1):9968.
Zhang, X., Du, L., Zhang, W., Yang, Y., Zhou, Q., & Du, G. (2017). Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis. Scientific Reports, 7(1), 9968. https://doi.org/10.1038/s41598-017-07442-y
Zhang X, et al. Therapeutic Effects of Baicalein On Rotenone-induced Parkinson's Disease Through Protecting Mitochondrial Function and Biogenesis. Sci Rep. 2017 08 30;7(1):9968. PubMed PMID: 28855526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis. AU - Zhang,Xue, AU - Du,Lida, AU - Zhang,Wen, AU - Yang,Yulin, AU - Zhou,Qimeng, AU - Du,Guanhua, Y1 - 2017/08/30/ PY - 2017/03/24/received PY - 2017/06/26/accepted PY - 2017/9/1/entrez PY - 2017/9/1/pubmed PY - 2019/4/23/medline SP - 9968 EP - 9968 JF - Scientific reports JO - Sci Rep VL - 7 IS - 1 N2 - Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD) for several decades, and disturbed mitochondrial biogenesis (mitobiogenesis) was recently found to be a common phenomenon in PD. Baicalein, a major bioactive flavone of Scutellaria baicalensis Georgi, exerted neuroprotective effects in several experimental PD models. However, the effects of baicalein in rotenone-induced PD rats and the possible mechanisms remain poorly understood. In this study, we evaluated the therapeutic effects of baicalein and explored its mechanism of action in rotenone-induced PD models. The results indicated that behavioural impairments and the depletion of dopaminergic neurons induced by rotenone were attenuated by baicalein. Furthermore, in rotenone-induced parkinsonian rats, baicalein treatment effectively restored mitochondrial function and improved mitobiogenesis, as determined by measuring the mitochondrial density and key regulators involved in mitobiogenesis. Additionally, we confirmed that baicalein enhanced mitobiogenesis through the cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3β (GSK-3β) pathways in rotenone-treated SH-SY5Y cells. Moreover, we demonstrated that the cytoprotective effects of baicalein could be attenuated by the mitobiogenesis inhibitor chloramphenicol as well as CREB siRNA transfection. Overall, our results suggested that baicalein partially enhanced mitobiogenesis to restore mitochondrial function, thus exerting therapeutic effects in rotenone-induced PD models. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28855526/Therapeutic_effects_of_baicalein_on_rotenone_induced_Parkinson's_disease_through_protecting_mitochondrial_function_and_biogenesis_ L2 - https://doi.org/10.1038/s41598-017-07442-y DB - PRIME DP - Unbound Medicine ER -