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Overall diet quality and risk of recurrence and progression of non-gallstone-related acute pancreatitis: a prospective cohort study.
Eur J Nutr. 2018 Oct; 57(7):2537-2545.EJ

Abstract

PURPOSE

An incident episode of acute pancreatitis is often followed by recurrent attacks and/or progression to chronic pancreatitis, especially if the etiology is non-gallstone-related. We examined whether overall diet quality influences the natural history of non-gallstone-related acute pancreatitis.

METHODS

Three hundred and eighty-six individuals (born 1914-1952) were included in a prospective study, all of whom had an incident diagnosis of non-gallstone-related acute pancreatitis in the Swedish National Patient Register between 1998 and 2013. Participants were already enrolled in two population-based cohorts and had completed a food frequency questionnaire in 1997. Overall diet quality was calculated using a recommended food score (RFS), which was based on 25 food items. Post-diagnosis follow-up was conducted throughout 2014 for recurrence of acute pancreatitis and/or progression to chronic pancreatic disease (including cancer). Hazard ratios were estimated using Cox models.

RESULTS

During 1859 person-years of follow-up, 23.3% of the study population (n = 90) developed recurrent or progressive pancreatic disease. An inverse association was observed between the RFS and risk of recurrent and progressive pancreatic disease after adjustment for age and sex (hazard ratio for each 2-unit increase 0.90, 95% confidence interval 0.81-1.01) (P overall association = 0.06). However, the association became weaker and was not statistically significant after adjustment for other potential confounders, including alcohol drinking and cigarette smoking (P overall association = 0.27).

CONCLUSIONS

In this prospective study of individuals with non-gallstone-related acute pancreatitis, there was no clear association between overall diet quality and risk of recurrent and progressive pancreatic disease.

Authors+Show Affiliations

Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 171 77, Stockholm, Sweden. viktor.oskarsson@ki.se.Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 171 77, Stockholm, Sweden. Centre for Clinical Research Sörmland, Uppsala University, 631 88, Eskilstuna, Sweden.Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 171 77, Stockholm, Sweden.Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 171 77, Stockholm, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28856418

Citation

Oskarsson, Viktor, et al. "Overall Diet Quality and Risk of Recurrence and Progression of Non-gallstone-related Acute Pancreatitis: a Prospective Cohort Study." European Journal of Nutrition, vol. 57, no. 7, 2018, pp. 2537-2545.
Oskarsson V, Sadr-Azodi O, Discacciati A, et al. Overall diet quality and risk of recurrence and progression of non-gallstone-related acute pancreatitis: a prospective cohort study. Eur J Nutr. 2018;57(7):2537-2545.
Oskarsson, V., Sadr-Azodi, O., Discacciati, A., Orsini, N., & Wolk, A. (2018). Overall diet quality and risk of recurrence and progression of non-gallstone-related acute pancreatitis: a prospective cohort study. European Journal of Nutrition, 57(7), 2537-2545. https://doi.org/10.1007/s00394-017-1526-8
Oskarsson V, et al. Overall Diet Quality and Risk of Recurrence and Progression of Non-gallstone-related Acute Pancreatitis: a Prospective Cohort Study. Eur J Nutr. 2018;57(7):2537-2545. PubMed PMID: 28856418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overall diet quality and risk of recurrence and progression of non-gallstone-related acute pancreatitis: a prospective cohort study. AU - Oskarsson,Viktor, AU - Sadr-Azodi,Omid, AU - Discacciati,Andrea, AU - Orsini,Nicola, AU - Wolk,Alicja, Y1 - 2017/08/30/ PY - 2017/05/02/received PY - 2017/08/14/accepted PY - 2017/9/1/pubmed PY - 2018/12/18/medline PY - 2017/9/1/entrez KW - Diet KW - Epidemiology KW - Pancreatitis KW - Prospective studies KW - Secondary prevention SP - 2537 EP - 2545 JF - European journal of nutrition JO - Eur J Nutr VL - 57 IS - 7 N2 - PURPOSE: An incident episode of acute pancreatitis is often followed by recurrent attacks and/or progression to chronic pancreatitis, especially if the etiology is non-gallstone-related. We examined whether overall diet quality influences the natural history of non-gallstone-related acute pancreatitis. METHODS: Three hundred and eighty-six individuals (born 1914-1952) were included in a prospective study, all of whom had an incident diagnosis of non-gallstone-related acute pancreatitis in the Swedish National Patient Register between 1998 and 2013. Participants were already enrolled in two population-based cohorts and had completed a food frequency questionnaire in 1997. Overall diet quality was calculated using a recommended food score (RFS), which was based on 25 food items. Post-diagnosis follow-up was conducted throughout 2014 for recurrence of acute pancreatitis and/or progression to chronic pancreatic disease (including cancer). Hazard ratios were estimated using Cox models. RESULTS: During 1859 person-years of follow-up, 23.3% of the study population (n = 90) developed recurrent or progressive pancreatic disease. An inverse association was observed between the RFS and risk of recurrent and progressive pancreatic disease after adjustment for age and sex (hazard ratio for each 2-unit increase 0.90, 95% confidence interval 0.81-1.01) (P overall association = 0.06). However, the association became weaker and was not statistically significant after adjustment for other potential confounders, including alcohol drinking and cigarette smoking (P overall association = 0.27). CONCLUSIONS: In this prospective study of individuals with non-gallstone-related acute pancreatitis, there was no clear association between overall diet quality and risk of recurrent and progressive pancreatic disease. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/28856418/Overall_diet_quality_and_risk_of_recurrence_and_progression_of_non_gallstone_related_acute_pancreatitis:_a_prospective_cohort_study_ L2 - https://dx.doi.org/10.1007/s00394-017-1526-8 DB - PRIME DP - Unbound Medicine ER -