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Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials.
J Int Med Res. 2018 Feb; 46(2):654-662.JI

Abstract

Objective To investigate the efficacy and safety of ondansetron during cesarean section under spinal anesthesia. Methods We sought randomized controlled trials (RCTs) on ondansetron during spinal anesthesia for cesarean section in The Cochrane Library, PubMed, MEDLINE, and Web of Science from their inception to September 2016. Results Altogether, 21 RCTs were included in this study. Meta-analysis showed that the ondansetron group had a lower incidence of nausea/vomiting and bradycardia than the placebo group during cesarean section under spinal anesthesia [relative risk (RR) = 0.43, 95% confidence interval (CI) (0.36, 0.51) and RR = 0.45, 95% CI (0.26, 0.80), respectively]. There were no significant differences in the incidences of pruritus, hypotension, or shivering during cesarean section under spinal anesthesia [RR = 0.92, 95% CI (0.83, 1.02); RR = 0.72 (0.50, 1.06), 95% CI (0.50, 1.06); and RR = 0.89, 95% CI (0.71, 1.11), respectively]. Conclusion Ondansetron effectively reduces the incidences of nausea/vomiting and bradycardia under spinal anesthesia during cesarean section.

Authors+Show Affiliations

1 117835 Zhaoqing Medical College , Zhaoqing, China.1 117835 Zhaoqing Medical College , Zhaoqing, China.1 117835 Zhaoqing Medical College , Zhaoqing, China.2 Department of Anesthesiology, The First People's Hospital of Changde, Changde, China.1 117835 Zhaoqing Medical College , Zhaoqing, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28856920

Citation

Zhou, Chengmao, et al. "Efficacy of Ondansetron for Spinal Anesthesia During Cesarean Section: a Meta-analysis of Randomized Trials." The Journal of International Medical Research, vol. 46, no. 2, 2018, pp. 654-662.
Zhou C, Zhu Y, Bao Z, et al. Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials. J Int Med Res. 2018;46(2):654-662.
Zhou, C., Zhu, Y., Bao, Z., Wang, X., & Liu, Q. (2018). Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials. The Journal of International Medical Research, 46(2), 654-662. https://doi.org/10.1177/0300060517716502
Zhou C, et al. Efficacy of Ondansetron for Spinal Anesthesia During Cesarean Section: a Meta-analysis of Randomized Trials. J Int Med Res. 2018;46(2):654-662. PubMed PMID: 28856920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of ondansetron for spinal anesthesia during cesarean section: a meta-analysis of randomized trials. AU - Zhou,Chengmao, AU - Zhu,Yu, AU - Bao,Zeqing, AU - Wang,Xianxue, AU - Liu,Qili, Y1 - 2017/08/31/ PY - 2017/9/1/pubmed PY - 2018/8/18/medline PY - 2017/9/1/entrez KW - Ondansetron KW - RCT KW - cesarean section KW - meta-analysis KW - nausea/vomiting KW - shivering KW - spinal anesthesia SP - 654 EP - 662 JF - The Journal of international medical research JO - J. Int. Med. Res. VL - 46 IS - 2 N2 - Objective To investigate the efficacy and safety of ondansetron during cesarean section under spinal anesthesia. Methods We sought randomized controlled trials (RCTs) on ondansetron during spinal anesthesia for cesarean section in The Cochrane Library, PubMed, MEDLINE, and Web of Science from their inception to September 2016. Results Altogether, 21 RCTs were included in this study. Meta-analysis showed that the ondansetron group had a lower incidence of nausea/vomiting and bradycardia than the placebo group during cesarean section under spinal anesthesia [relative risk (RR) = 0.43, 95% confidence interval (CI) (0.36, 0.51) and RR = 0.45, 95% CI (0.26, 0.80), respectively]. There were no significant differences in the incidences of pruritus, hypotension, or shivering during cesarean section under spinal anesthesia [RR = 0.92, 95% CI (0.83, 1.02); RR = 0.72 (0.50, 1.06), 95% CI (0.50, 1.06); and RR = 0.89, 95% CI (0.71, 1.11), respectively]. Conclusion Ondansetron effectively reduces the incidences of nausea/vomiting and bradycardia under spinal anesthesia during cesarean section. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/28856920/Efficacy_of_ondansetron_for_spinal_anesthesia_during_cesarean_section:_a_meta_analysis_of_randomized_trials_ L2 - http://journals.sagepub.com/doi/full/10.1177/0300060517716502?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -