Tags

Type your tag names separated by a space and hit enter

Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome.
J Psychopharmacol. 2017 09; 31(9):1250-1262.JP

Abstract

Animal and clinical researches indicate that the opioid system exerts a crucial role in the etiology of mood disorders and is a target for intervention in depression treatment. This study investigated the contribution of the opioid system to the antidepressant-like action of acute or repeated m-trifluoromethyl-diphenyl diselenide administration to Swiss mice. m-Trifluoromethyl-diphenyl diselenide (50 mg/kg, intragastric) produced an antidepressant-like action in the forced swimming test from 30 min to 24 h after treatment. This effect was blocked by the µ and δ-opioid receptor antagonists, naloxonazine (10 mg/kg, intraperitoneally) and naltrindole (3 mg/kg, intraperitoneally), and it was potentiated by a κ-opioid receptor antagonist, norbinaltrophimine (1 mg/kg, subcutaneously). Combined treatment with subeffective doses of m-trifluoromethyl-diphenyl diselenide (10 mg/kg, intragastric) and morphine (1 mg/kg, subcutaneously) resulted in a synergistic antidepressant-like effect. The opioid system contribution to the m-trifluoromethyl-diphenyl diselenide antidepressant-like action was also demonstrated in the modified tail suspension test, decreasing mouse immobility and swinging time and increasing curling time, results similar to those observed using morphine, a positive control. Treatment with m-trifluoromethyl-diphenyl diselenide induced neither tolerance to the antidepressant-like action nor physical signs of withdrawal, which could be associated with the fact that m-trifluoromethyl-diphenyl diselenide did not change the mouse cortical and hippocampal glutamate uptake and release. m-Trifluoromethyl-diphenyl diselenide treatments altered neither locomotor nor toxicological parameters in mice. These findings demonstrate that m-trifluoromethyl-diphenyl diselenide elicited an antidepressant-like action by direct or indirect μ and δ-opioid receptor activation and the κ-opioid receptor blockade, without inducing tolerance, physical signs of withdrawal and toxicity.

Authors+Show Affiliations

1 Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, Brasil.1 Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, Brasil.1 Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, Brasil.2 Departamento de Patologia, Universidade Federal de Santa Maria, Santa Maria, Brazil.1 Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, Brasil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28857657

Citation

Rosa, Suzan G., et al. "Opioid System Contribution to the Antidepressant-like Action of M-trifluoromethyl-diphenyl Diselenide in Mice: a Compound Devoid of Tolerance and Withdrawal Syndrome." Journal of Psychopharmacology (Oxford, England), vol. 31, no. 9, 2017, pp. 1250-1262.
Rosa SG, Pesarico AP, Tagliapietra CF, et al. Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome. J Psychopharmacol. 2017;31(9):1250-1262.
Rosa, S. G., Pesarico, A. P., Tagliapietra, C. F., da Luz, S. C., & Nogueira, C. W. (2017). Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome. Journal of Psychopharmacology (Oxford, England), 31(9), 1250-1262. https://doi.org/10.1177/0269881117724353
Rosa SG, et al. Opioid System Contribution to the Antidepressant-like Action of M-trifluoromethyl-diphenyl Diselenide in Mice: a Compound Devoid of Tolerance and Withdrawal Syndrome. J Psychopharmacol. 2017;31(9):1250-1262. PubMed PMID: 28857657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome. AU - Rosa,Suzan G, AU - Pesarico,Ana P, AU - Tagliapietra,Carolina F, AU - da Luz,Sônia Ca, AU - Nogueira,Cristina W, Y1 - 2017/08/31/ PY - 2017/9/1/pubmed PY - 2018/5/18/medline PY - 2017/9/1/entrez KW - Antidepressant-like KW - opioid system KW - selenium KW - tolerance KW - withdrawal signs SP - 1250 EP - 1262 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 31 IS - 9 N2 - Animal and clinical researches indicate that the opioid system exerts a crucial role in the etiology of mood disorders and is a target for intervention in depression treatment. This study investigated the contribution of the opioid system to the antidepressant-like action of acute or repeated m-trifluoromethyl-diphenyl diselenide administration to Swiss mice. m-Trifluoromethyl-diphenyl diselenide (50 mg/kg, intragastric) produced an antidepressant-like action in the forced swimming test from 30 min to 24 h after treatment. This effect was blocked by the µ and δ-opioid receptor antagonists, naloxonazine (10 mg/kg, intraperitoneally) and naltrindole (3 mg/kg, intraperitoneally), and it was potentiated by a κ-opioid receptor antagonist, norbinaltrophimine (1 mg/kg, subcutaneously). Combined treatment with subeffective doses of m-trifluoromethyl-diphenyl diselenide (10 mg/kg, intragastric) and morphine (1 mg/kg, subcutaneously) resulted in a synergistic antidepressant-like effect. The opioid system contribution to the m-trifluoromethyl-diphenyl diselenide antidepressant-like action was also demonstrated in the modified tail suspension test, decreasing mouse immobility and swinging time and increasing curling time, results similar to those observed using morphine, a positive control. Treatment with m-trifluoromethyl-diphenyl diselenide induced neither tolerance to the antidepressant-like action nor physical signs of withdrawal, which could be associated with the fact that m-trifluoromethyl-diphenyl diselenide did not change the mouse cortical and hippocampal glutamate uptake and release. m-Trifluoromethyl-diphenyl diselenide treatments altered neither locomotor nor toxicological parameters in mice. These findings demonstrate that m-trifluoromethyl-diphenyl diselenide elicited an antidepressant-like action by direct or indirect μ and δ-opioid receptor activation and the κ-opioid receptor blockade, without inducing tolerance, physical signs of withdrawal and toxicity. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/28857657/Opioid_system_contribution_to_the_antidepressant_like_action_of_m_trifluoromethyl_diphenyl_diselenide_in_mice:_A_compound_devoid_of_tolerance_and_withdrawal_syndrome_ L2 - https://journals.sagepub.com/doi/10.1177/0269881117724353?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -