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Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs.
BMC Complement Altern Med. 2017 Aug 31; 17(1):436.BC

Abstract

BACKGROUND

Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective intervention for PD. Our aim was to determine the effectiveness of acupoint-stimulation compared with Non-Steroidal Anti-Inflammatory Drugs (NASIDs) in the treatment of PD.

METHODS

Six databases were searched to December 2014. Sixteen studies involving 1679 PD patients were included. We included randomized controlled trials that compared acupoint-stimulation with NASIDs for the treatment of PD. The main outcomes assessed were clinical effectiveness rate, symptom score, visual analogue score, variation in peripheral blood prostaglandin F2α (PGF2α) and side effects. All analyses were performed using Comprehensive Meta-Analysis statistical software.

RESULTS

(1) The total efficacy was better than control group: odds ratio = 5.57; 95% confidence interval (95% CI) = 3.96, 7.83; P < 0.00001; (2) The effect of intervention was positive in relieving the severity of PD symptoms: mean difference (MD) = 2.99; 95%CI = 2.49, 3.49; P < 0.00001; (3) No statistical difference existed between two groups in terms of a reduction in the VAS: MD = 1.24; 95%CI = -3.37, 5.85; P = 0.60; (4) The effect of intervention on the variation in peripheral blood PGF2α between two groups was positive: MD = 7.55; 95%CI = 4.29,10.82; P < 0.00001; (5) The side effects of control groups was more than the acupoint-stimulation group: OR = 0.03; 95%CI =0.00,0.22; P = 0.0005.

CONCLUSIONS

According to this article, acupoint-stimulation can relieve pain effectively in the treatment of PD and offers advantages in increasing the overall effectiveness.

Authors+Show Affiliations

Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Department of Gynecology and Obstetrics, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin, 300100, China.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Department of Neurology, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin, 300100, China.Department of Chinese Medicine, Tianjin Hearing Impairment Specialist Hospital, Tianjin, 300150, China.Department of Public Health, School of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.Department of Gynecology and Obstetrics of Chinese Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.Department of Chemical Engineering, University of Florida, 1006 Center Drive, Gainesville, FL, 32611, USA. zaky@ufl.edu. Institute for Cell & Tissue Science and Engineering, University of Florida, Gainesville, FL, 32611, USA. zaky@ufl.edu.Laboratory of Anatomy, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yu Quan Road, Nankai District, Tianjin, 300193, China. haiguagua@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28859645

Citation

Xu, Yang, et al. "Effects of Acupoint-stimulation for the Treatment of Primary Dysmenorrhoea Compared With NSAIDs: a Systematic Review and Meta-analysis of 19 RCTs." BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017, p. 436.
Xu Y, Zhao W, Li T, et al. Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs. BMC Complement Altern Med. 2017;17(1):436.
Xu, Y., Zhao, W., Li, T., Bu, H., Zhao, Z., Zhao, Y., & Song, S. (2017). Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs. BMC Complementary and Alternative Medicine, 17(1), 436. https://doi.org/10.1186/s12906-017-1924-8
Xu Y, et al. Effects of Acupoint-stimulation for the Treatment of Primary Dysmenorrhoea Compared With NSAIDs: a Systematic Review and Meta-analysis of 19 RCTs. BMC Complement Altern Med. 2017 Aug 31;17(1):436. PubMed PMID: 28859645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs. AU - Xu,Yang, AU - Zhao,Wenli, AU - Li,Te, AU - Bu,Huaien, AU - Zhao,Zhimei, AU - Zhao,Ye, AU - Song,Shilin, Y1 - 2017/08/31/ PY - 2016/11/07/received PY - 2017/08/11/accepted PY - 2017/9/2/entrez PY - 2017/9/2/pubmed PY - 2017/9/9/medline KW - Acupoint-stimulation KW - Meta-analysis KW - Non-steroidal anti-inflammatory drugs KW - Primary dysmenorrhoea KW - Systematic review SP - 436 EP - 436 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 17 IS - 1 N2 - BACKGROUND: Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective intervention for PD. Our aim was to determine the effectiveness of acupoint-stimulation compared with Non-Steroidal Anti-Inflammatory Drugs (NASIDs) in the treatment of PD. METHODS: Six databases were searched to December 2014. Sixteen studies involving 1679 PD patients were included. We included randomized controlled trials that compared acupoint-stimulation with NASIDs for the treatment of PD. The main outcomes assessed were clinical effectiveness rate, symptom score, visual analogue score, variation in peripheral blood prostaglandin F2α (PGF2α) and side effects. All analyses were performed using Comprehensive Meta-Analysis statistical software. RESULTS: (1) The total efficacy was better than control group: odds ratio = 5.57; 95% confidence interval (95% CI) = 3.96, 7.83; P < 0.00001; (2) The effect of intervention was positive in relieving the severity of PD symptoms: mean difference (MD) = 2.99; 95%CI = 2.49, 3.49; P < 0.00001; (3) No statistical difference existed between two groups in terms of a reduction in the VAS: MD = 1.24; 95%CI = -3.37, 5.85; P = 0.60; (4) The effect of intervention on the variation in peripheral blood PGF2α between two groups was positive: MD = 7.55; 95%CI = 4.29,10.82; P < 0.00001; (5) The side effects of control groups was more than the acupoint-stimulation group: OR = 0.03; 95%CI =0.00,0.22; P = 0.0005. CONCLUSIONS: According to this article, acupoint-stimulation can relieve pain effectively in the treatment of PD and offers advantages in increasing the overall effectiveness. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/28859645/Effects_of_acupoint_stimulation_for_the_treatment_of_primary_dysmenorrhoea_compared_with_NSAIDs:_a_systematic_review_and_meta_analysis_of_19_RCTs_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1924-8 DB - PRIME DP - Unbound Medicine ER -