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Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial.
Trials. 2017 08 31; 18(1):405.T

Abstract

BACKGROUND

Aerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes.

METHODS/DESIGN

Stroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups. All participants will receive training for 60 minutes per day, 3 days per week for 12 weeks. The aerobic exercise group will receive stationary bicycle training, the cognitive training group will receive cognitive-based training, and the sequential group will first receive 30 minutes of aerobic exercise, followed by 30 minutes of cognitive training. The outcome measures involve cognitive functions, physiological biomarkers, daily function and quality of life, physical functions, and social participation. Participants will be assessed before and immediately after the interventions, and 6 months after the interventions. Repeated measures of analysis of variance will be used to evaluate the changes in outcome measures at the three assessments.

DISCUSSION

This trial aims to explore the benefits of innovative intervention approaches to improve the cognitive function, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline. The findings will provide evidence to advance post-stroke cognitive rehabilitation.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT02550990 . Registered on 6 September 2015.

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Authors+Show Affiliations

Yeh TT
School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wu CY
Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. cywu@mail.cgu.edu.tw. Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan. cywu@mail.cgu.edu.tw. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. cywu@mail.cgu.edu.tw.
Hsieh YW
Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan. Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Chang KC
Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. kcchang@cgmh.org.tw.
Lee LC
Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan.
Hung JW
Department of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
Lin KC
School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan. Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
Teng CH
Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Liao YH
Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.

MeSH

Activities of Daily LivingAdultAgedAged, 80 and overBicyclingClinical ProtocolsCognitionCognition DisordersCognitive Behavioral TherapyCombined Modality TherapyDisability EvaluationExercise TherapyFemaleHumansMaleMental Status and Dementia TestsMiddle AgedQuality of LifeRecovery of FunctionResearch DesignSingle-Blind MethodSocial ParticipationStrokeStroop TestTaiwanTime FactorsTreatment OutcomeWalk TestYoung Adult

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

28859664

Clinical Trial Links

Clinical trial which this article describes

Citation

Yeh, Ting-Ting, et al. "Synergistic Effects of Aerobic Exercise and Cognitive Training On Cognition, Physiological Markers, Daily Function, and Quality of Life in Stroke Survivors With Cognitive Decline: Study Protocol for a Randomized Controlled Trial." Trials, vol. 18, no. 1, 2017, p. 405.
Yeh TT, Wu CY, Hsieh YW, et al. Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial. Trials. 2017;18(1):405.
Yeh, T. T., Wu, C. Y., Hsieh, Y. W., Chang, K. C., Lee, L. C., Hung, J. W., Lin, K. C., Teng, C. H., & Liao, Y. H. (2017). Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial. Trials, 18(1), 405. https://doi.org/10.1186/s13063-017-2153-7
Yeh TT, et al. Synergistic Effects of Aerobic Exercise and Cognitive Training On Cognition, Physiological Markers, Daily Function, and Quality of Life in Stroke Survivors With Cognitive Decline: Study Protocol for a Randomized Controlled Trial. Trials. 2017 08 31;18(1):405. PubMed PMID: 28859664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial. AU - Yeh,Ting-Ting, AU - Wu,Ching-Yi, AU - Hsieh,Yu-Wei, AU - Chang,Ku-Chou, AU - Lee,Lin-Chien, AU - Hung,Jen-Wen, AU - Lin,Keh-Chung, AU - Teng,Ching-Hung, AU - Liao,Yi-Han, Y1 - 2017/08/31/ PY - 2017/03/03/received PY - 2017/08/16/accepted PY - 2017/9/2/entrez PY - 2017/9/2/pubmed PY - 2018/5/22/medline KW - Aerobic exercise KW - Cognitive rehabilitation KW - Cognitive training KW - Sequential training KW - Stroke SP - 405 EP - 405 JF - Trials JO - Trials VL - 18 IS - 1 N2 - BACKGROUND: Aerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes. METHODS/DESIGN: Stroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups. All participants will receive training for 60 minutes per day, 3 days per week for 12 weeks. The aerobic exercise group will receive stationary bicycle training, the cognitive training group will receive cognitive-based training, and the sequential group will first receive 30 minutes of aerobic exercise, followed by 30 minutes of cognitive training. The outcome measures involve cognitive functions, physiological biomarkers, daily function and quality of life, physical functions, and social participation. Participants will be assessed before and immediately after the interventions, and 6 months after the interventions. Repeated measures of analysis of variance will be used to evaluate the changes in outcome measures at the three assessments. DISCUSSION: This trial aims to explore the benefits of innovative intervention approaches to improve the cognitive function, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline. The findings will provide evidence to advance post-stroke cognitive rehabilitation. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02550990 . Registered on 6 September 2015. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/28859664/Synergistic_effects_of_aerobic_exercise_and_cognitive_training_on_cognition_physiological_markers_daily_function_and_quality_of_life_in_stroke_survivors_with_cognitive_decline:_study_protocol_for_a_randomized_controlled_trial_ L2 - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2153-7 DB - PRIME DP - Unbound Medicine ER -
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