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Liposomal curcumin and its application in cancer.
Int J Nanomedicine. 2017; 12:6027-6044.IJ

Abstract

Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Authors+Show Affiliations

Feng T
Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Wei Y
Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Lee RJ
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Zhao L
Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

MeSH

Antineoplastic Agents, PhytogenicBiological AvailabilityCurcumaCurcuminDrug Delivery SystemsHumansLiposomesNanoparticlesNeoplasmsSolubility

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28860764

Citation

Feng, Ting, et al. "Liposomal Curcumin and Its Application in Cancer." International Journal of Nanomedicine, vol. 12, 2017, pp. 6027-6044.
Feng T, Wei Y, Lee RJ, et al. Liposomal curcumin and its application in cancer. Int J Nanomedicine. 2017;12:6027-6044.
Feng, T., Wei, Y., Lee, R. J., & Zhao, L. (2017). Liposomal curcumin and its application in cancer. International Journal of Nanomedicine, 12, 6027-6044. https://doi.org/10.2147/IJN.S132434
Feng T, et al. Liposomal Curcumin and Its Application in Cancer. Int J Nanomedicine. 2017;12:6027-6044. PubMed PMID: 28860764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liposomal curcumin and its application in cancer. AU - Feng,Ting, AU - Wei,Yumeng, AU - Lee,Robert J, AU - Zhao,Ling, Y1 - 2017/08/21/ PY - 2017/9/2/entrez PY - 2017/9/2/pubmed PY - 2018/3/9/medline KW - bioavailability KW - cancer KW - curcumin KW - drug delivery KW - liposomes SP - 6027 EP - 6044 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 12 N2 - Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/28860764/Liposomal_curcumin_and_its_application_in_cancer_ L2 - https://dx.doi.org/10.2147/IJN.S132434 DB - PRIME DP - Unbound Medicine ER -