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Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy.
Graefes Arch Clin Exp Ophthalmol. 2017 Nov; 255(11):2255-2261.GA

Abstract

PURPOSE

The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA).

METHODS

In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation. The characteristics of the images were analyzed. Optic nerve head (ONH) and radial peripapillary capillaries (RPC) vessel densities (VDs) were compared between NA-AION and controls.

RESULTS

In two of four NA-AION cases and in the A-AION patient, OCT-A clearly identified the boundary of the ischemic area at the level of the optic nerve head, which was comparable to optic disc filling defects detected by FA. In the other two NA-AION cases, a generalized leakage from the disc was visible with FA, yet OCT-A still demonstrated sectorial peripapillary capillary network reduction. Both ONH and RPC VDs were reduced in NA-AION patients, when compared to controls.

CONCLUSIONS

OCT-A was able to identify microvascular defects and VD reduction in cases of acute optic disc edema due to NA-AION and A-AION. OCT-A provides additional information in ischemic conditions of the optic nerve head.

Authors+Show Affiliations

Studio Oculistico d'Azeglio, Piazza Galileo 6, 40123, Bologna, Italy. balduccinicole@gmail.com. Ophthalmology Unit, Sant'Orsola-Malpighi Hospital, Bologna, Italy. balduccinicole@gmail.com.Ophthalmology Unit, Sant'Orsola-Malpighi Hospital, Bologna, Italy.Ophthalmology Unit, Sant'Orsola-Malpighi Hospital, Bologna, Italy.Studio Oculistico d'Azeglio, Piazza Galileo 6, 40123, Bologna, Italy. Scientific Institute San Raffaele, Via Olgettina, 60, Milan, Italy.Ophthalmology Unit, Sant'Orsola-Malpighi Hospital, Bologna, Italy.GB Bietti Foundation IRCCS, Via Livenza, 3, 00128, Rome, Italy.GB Bietti Foundation IRCCS, Via Livenza, 3, 00128, Rome, Italy.Department of Ophthalmology, Doheny Eye Institute, University of California, Los Angeles, CA, USA.Ophthalmology Unit, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28861697

Citation

Balducci, Nicole, et al. "Optical Coherence Tomography Angiography in Acute Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 255, no. 11, 2017, pp. 2255-2261.
Balducci N, Morara M, Veronese C, et al. Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(11):2255-2261.
Balducci, N., Morara, M., Veronese, C., Barboni, P., Casadei, N. L., Savini, G., Parisi, V., Sadun, A. A., & Ciardella, A. (2017). Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(11), 2255-2261. https://doi.org/10.1007/s00417-017-3774-y
Balducci N, et al. Optical Coherence Tomography Angiography in Acute Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy. Graefes Arch Clin Exp Ophthalmol. 2017;255(11):2255-2261. PubMed PMID: 28861697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. AU - Balducci,Nicole, AU - Morara,Mariachiara, AU - Veronese,Chiara, AU - Barboni,Piero, AU - Casadei,Nicoletta Lelli, AU - Savini,Giacomo, AU - Parisi,Vincenzo, AU - Sadun,Alfredo A, AU - Ciardella,Antonio, Y1 - 2017/08/31/ PY - 2017/03/27/received PY - 2017/08/02/accepted PY - 2017/07/25/revised PY - 2017/9/2/pubmed PY - 2017/12/16/medline PY - 2017/9/2/entrez KW - A-AION KW - Arteritic anterior ischemic optic neuropathy KW - Fluorescein angiography KW - NA-AION KW - Non-arteritic anterior ischemic optic neuropathy KW - OCT-A;optical coherence tomography angiography KW - Vessel density SP - 2255 EP - 2261 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 255 IS - 11 N2 - PURPOSE: The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHODS: In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation. The characteristics of the images were analyzed. Optic nerve head (ONH) and radial peripapillary capillaries (RPC) vessel densities (VDs) were compared between NA-AION and controls. RESULTS: In two of four NA-AION cases and in the A-AION patient, OCT-A clearly identified the boundary of the ischemic area at the level of the optic nerve head, which was comparable to optic disc filling defects detected by FA. In the other two NA-AION cases, a generalized leakage from the disc was visible with FA, yet OCT-A still demonstrated sectorial peripapillary capillary network reduction. Both ONH and RPC VDs were reduced in NA-AION patients, when compared to controls. CONCLUSIONS: OCT-A was able to identify microvascular defects and VD reduction in cases of acute optic disc edema due to NA-AION and A-AION. OCT-A provides additional information in ischemic conditions of the optic nerve head. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/28861697/Optical_coherence_tomography_angiography_in_acute_arteritic_and_non_arteritic_anterior_ischemic_optic_neuropathy_ L2 - https://dx.doi.org/10.1007/s00417-017-3774-y DB - PRIME DP - Unbound Medicine ER -