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Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia.
Clin Ther. 1987; 9(4):429-33.CT

Abstract

Anticholinergic drugs have been shown to impair new memory acquisition. In a double-blind study, 22 chronically schizophrenic patients had the anticholinergic drugs that they had been taking to control the extrapyramidal side effects (EPSE) of neuroleptic drugs discontinued and were randomly assigned to treatment either with benztropine (an anticholinergic) or with amantadine (which has little or no anticholinergic effect). The EPSE of five of the ten patients assigned to amantadine could not be adequately controlled with that drug alone, and these patients were withdrawn from the study prematurely. The five patients who completed the six-week trial on amantadine showed improved performance on tests of memory acquisition in comparison with patients treated with benztropine. Global inspection of the results showed that only 36% of the patients taking benztropine showed improvement in memory acquisition at the four- and six-week assessments, whereas 80% of the amantadine users showed improvement at the four-week assessment. Analysis of covariance, however, revealed that the performance of the latter group decreased almost to baseline at six weeks, as an additional two of the remaining patients developed distressing EPSE.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2886223

Citation

McEvoy, J P., et al. "Replacement of Chronically Administered Anticholinergic Drugs By Amantadine in Outpatient Management of Chronic Schizophrenia." Clinical Therapeutics, vol. 9, no. 4, 1987, pp. 429-33.
McEvoy JP, McCue M, Freter S. Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia. Clin Ther. 1987;9(4):429-33.
McEvoy, J. P., McCue, M., & Freter, S. (1987). Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia. Clinical Therapeutics, 9(4), 429-33.
McEvoy JP, McCue M, Freter S. Replacement of Chronically Administered Anticholinergic Drugs By Amantadine in Outpatient Management of Chronic Schizophrenia. Clin Ther. 1987;9(4):429-33. PubMed PMID: 2886223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia. AU - McEvoy,J P, AU - McCue,M, AU - Freter,S, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 429 EP - 33 JF - Clinical therapeutics JO - Clin Ther VL - 9 IS - 4 N2 - Anticholinergic drugs have been shown to impair new memory acquisition. In a double-blind study, 22 chronically schizophrenic patients had the anticholinergic drugs that they had been taking to control the extrapyramidal side effects (EPSE) of neuroleptic drugs discontinued and were randomly assigned to treatment either with benztropine (an anticholinergic) or with amantadine (which has little or no anticholinergic effect). The EPSE of five of the ten patients assigned to amantadine could not be adequately controlled with that drug alone, and these patients were withdrawn from the study prematurely. The five patients who completed the six-week trial on amantadine showed improved performance on tests of memory acquisition in comparison with patients treated with benztropine. Global inspection of the results showed that only 36% of the patients taking benztropine showed improvement in memory acquisition at the four- and six-week assessments, whereas 80% of the amantadine users showed improvement at the four-week assessment. Analysis of covariance, however, revealed that the performance of the latter group decreased almost to baseline at six weeks, as an additional two of the remaining patients developed distressing EPSE. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/2886223/Replacement_of_chronically_administered_anticholinergic_drugs_by_amantadine_in_outpatient_management_of_chronic_schizophrenia_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -