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The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.
ACS Chem Neurosci. 2017 11 15; 8(11):2356-2368.AC

Abstract

Among the diseases affecting the central nervous system (CNS), neurodegenerations attract the interest of both the clinician and the medicinal chemist. The increasing average age of population, the growing number of patients, and the lack of long-term effective remedies push ahead the quest for novel tools against this class of pathologies. We present a review on the state of the art of the molecules (or combination of molecules) of natural origin that are currently under study against two well-defined pathologies: Parkinson's disease (PD) and Huntington's disease (HD). Nowadays, very few tools are available for preventing or counteracting the progression of such diseases. Two major parameters were considered for the preparation of this review: particular attention was reserved to these research works presenting well-defined molecular mechanisms for the studied compounds, and where available, papers reporting in vivo data were preferred. A literature search for peer-reviewed articles using PubMed, Scopus, and Reaxys databases was performed, exploiting different keywords and logical operators: 91 papers were considered (preferentially published after 2015). The review presents a brief overview on the etiology of the studied neurodegenerations and the current treatments, followed by a detailed discussion of the natural and semisynthetic compounds dividing them in different paragraphs considering their several mechanisms of action.

Authors+Show Affiliations

Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Padova 35131, Italy.Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Padova 35131, Italy.Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Padova 35131, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28862431

Citation

Zanforlin, Enrico, et al. "The Medicinal Chemistry of Natural and Semisynthetic Compounds Against Parkinson's and Huntington's Diseases." ACS Chemical Neuroscience, vol. 8, no. 11, 2017, pp. 2356-2368.
Zanforlin E, Zagotto G, Ribaudo G. The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases. ACS Chem Neurosci. 2017;8(11):2356-2368.
Zanforlin, E., Zagotto, G., & Ribaudo, G. (2017). The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases. ACS Chemical Neuroscience, 8(11), 2356-2368. https://doi.org/10.1021/acschemneuro.7b00283
Zanforlin E, Zagotto G, Ribaudo G. The Medicinal Chemistry of Natural and Semisynthetic Compounds Against Parkinson's and Huntington's Diseases. ACS Chem Neurosci. 2017 11 15;8(11):2356-2368. PubMed PMID: 28862431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases. AU - Zanforlin,Enrico, AU - Zagotto,Giuseppe, AU - Ribaudo,Giovanni, Y1 - 2017/09/15/ PY - 2017/9/2/pubmed PY - 2018/6/27/medline PY - 2017/9/2/entrez KW - CNS KW - Dementia KW - Huntington’s disease KW - Parkinson’s disease KW - natural products KW - semisynthetic compounds SP - 2356 EP - 2368 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 8 IS - 11 N2 - Among the diseases affecting the central nervous system (CNS), neurodegenerations attract the interest of both the clinician and the medicinal chemist. The increasing average age of population, the growing number of patients, and the lack of long-term effective remedies push ahead the quest for novel tools against this class of pathologies. We present a review on the state of the art of the molecules (or combination of molecules) of natural origin that are currently under study against two well-defined pathologies: Parkinson's disease (PD) and Huntington's disease (HD). Nowadays, very few tools are available for preventing or counteracting the progression of such diseases. Two major parameters were considered for the preparation of this review: particular attention was reserved to these research works presenting well-defined molecular mechanisms for the studied compounds, and where available, papers reporting in vivo data were preferred. A literature search for peer-reviewed articles using PubMed, Scopus, and Reaxys databases was performed, exploiting different keywords and logical operators: 91 papers were considered (preferentially published after 2015). The review presents a brief overview on the etiology of the studied neurodegenerations and the current treatments, followed by a detailed discussion of the natural and semisynthetic compounds dividing them in different paragraphs considering their several mechanisms of action. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/28862431/The_Medicinal_Chemistry_of_Natural_and_Semisynthetic_Compounds_against_Parkinson's_and_Huntington's_Diseases_ L2 - https://doi.org/10.1021/acschemneuro.7b00283 DB - PRIME DP - Unbound Medicine ER -