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Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes.
ACS Sens 2017; 2(10):1505-1511AS

Abstract

The detection of four different polyquaterniums (PQs) using a fully reversible potentiometric polyion sensor in three different detection modes is described. The polyion sensing "pulstrodes" serve as the detector for direct dose-response experiments, beaker titrations, and in a flow-injection analysis (FIA) system. Direct polycation response toward PQ-2, PQ-6, PQ-10, and poly(2-methacryloxyethyltrimethylammonium) chloride (PMETAC) yields characteristic information about each PQ species (e.g., relative charge densities, etc.) via syringe pump addition of each PQ species to a background electrolyte solution. Quantitative titrations are performed using a syringe pump to deliver heparin as the polyanion titrant to quantify all four PQs at μg/mL levels. Both the direct and indirect methods incorporate the use of a three-electrode system including counter, double junction reference, and working electrodes. The working electrode possesses a plasticized poly(vinyl chloride) (PVC) membrane containing the neutral lipophilic salt of dinonylnaphthalenesulfonate (DNNS-) tridodecylmethylammonium (TDMA+). Further, the titration method is shown to be useful to quantify PQ-6 levels in recreational swimming pool water collected in Ann Arbor, MI. Finally, a FIA system equipped with a pulstrode detector is used to demonstrate the ability to potentially quantify PQ levels via a more streamlined and semiautomated testing platform.

Authors+Show Affiliations

Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28862444

Citation

Ferguson, Stephen A., and Mark E. Meyerhoff. "Manual and Flow-Injection Detection/Quantification of Polyquaterniums Via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes." ACS Sensors, vol. 2, no. 10, 2017, pp. 1505-1511.
Ferguson SA, Meyerhoff ME. Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes. ACS Sens. 2017;2(10):1505-1511.
Ferguson, S. A., & Meyerhoff, M. E. (2017). Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes. ACS Sensors, 2(10), pp. 1505-1511. doi:10.1021/acssensors.7b00527.
Ferguson SA, Meyerhoff ME. Manual and Flow-Injection Detection/Quantification of Polyquaterniums Via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes. ACS Sens. 2017 10 27;2(10):1505-1511. PubMed PMID: 28862444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes. AU - Ferguson,Stephen A, AU - Meyerhoff,Mark E, Y1 - 2017/09/18/ PY - 2017/9/2/pubmed PY - 2018/2/14/medline PY - 2017/9/2/entrez KW - flow-injection analysis KW - polyquaternium KW - potentiometric titration KW - potentiometry KW - pulstrode SP - 1505 EP - 1511 JF - ACS sensors JO - ACS Sens VL - 2 IS - 10 N2 - The detection of four different polyquaterniums (PQs) using a fully reversible potentiometric polyion sensor in three different detection modes is described. The polyion sensing "pulstrodes" serve as the detector for direct dose-response experiments, beaker titrations, and in a flow-injection analysis (FIA) system. Direct polycation response toward PQ-2, PQ-6, PQ-10, and poly(2-methacryloxyethyltrimethylammonium) chloride (PMETAC) yields characteristic information about each PQ species (e.g., relative charge densities, etc.) via syringe pump addition of each PQ species to a background electrolyte solution. Quantitative titrations are performed using a syringe pump to deliver heparin as the polyanion titrant to quantify all four PQs at μg/mL levels. Both the direct and indirect methods incorporate the use of a three-electrode system including counter, double junction reference, and working electrodes. The working electrode possesses a plasticized poly(vinyl chloride) (PVC) membrane containing the neutral lipophilic salt of dinonylnaphthalenesulfonate (DNNS-) tridodecylmethylammonium (TDMA+). Further, the titration method is shown to be useful to quantify PQ-6 levels in recreational swimming pool water collected in Ann Arbor, MI. Finally, a FIA system equipped with a pulstrode detector is used to demonstrate the ability to potentially quantify PQ levels via a more streamlined and semiautomated testing platform. SN - 2379-3694 UR - https://www.unboundmedicine.com/medline/citation/28862444/Manual_and_Flow_Injection_Detection/Quantification_of_Polyquaterniums_via_Fully_Reversible_Polyion_Sensitive_Polymeric_Membrane_Based_Ion_Selective_Electrodes_ DB - PRIME DP - Unbound Medicine ER -