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A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma.
Leuk Lymphoma 2018; 59(5):1180-1187LL

Abstract

Hodgkin lymphoma (HL) survivors are at increased risk of thyroid cancer (TC). We sought to determine whether increased risks of high-risk pathology or mortality are seen with thyroid cancer after HL (HL-TC) compared with first primary thyroid cancer (TC-1). From the Surveillance, Epidemiology and End Results (SEER) registry, we compared patient and tumor characteristics as well as survival outcomes between HL-TC and TC-1 and fit a multivariable Cox model to assess for a possible association between HL history and overall survival after TC. Among 139,297 TC-1 and 174 HL-TC patients, history of HL was not associated with anaplastic or sarcoma TC. Multivariable analyzes showed that history of HL was not associated with a difference in risk of death after TC (hazard ratio: 0.96, 95% confidence interval: (0.81, 1.13), p = .61). Despite a significantly increased risk of TC among HL survivors, prior HL is not associated with more aggressive pathologic subtypes or worse prognosis.

Authors+Show Affiliations

a University of Rochester School of Medicine , Rochester , NY , USA.b University of Rochester Medical Center , Division of Medical Oncology , Rochester , NY , USA.c Department of Radiation Oncology , Massachusetts General Hospital , Boston , MA , USA.d Department of Radiation Oncology , University of Rochester Medical Center , Rochester , NY , USA.d Department of Radiation Oncology , University of Rochester Medical Center , Rochester , NY , USA.d Department of Radiation Oncology , University of Rochester Medical Center , Rochester , NY , USA.d Department of Radiation Oncology , University of Rochester Medical Center , Rochester , NY , USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28862484

Citation

Chowdhry, Amit K., et al. "A Population-based Study of Prognosis and Survival in Patients With Second Primary Thyroid Cancer After Hodgkin Lymphoma." Leukemia & Lymphoma, vol. 59, no. 5, 2018, pp. 1180-1187.
Chowdhry AK, Fung C, Chowdhry VK, et al. A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma. Leuk Lymphoma. 2018;59(5):1180-1187.
Chowdhry, A. K., Fung, C., Chowdhry, V. K., Bergsma, D., Dhakal, S., Constine, L. S., & Milano, M. T. (2018). A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma. Leukemia & Lymphoma, 59(5), pp. 1180-1187. doi:10.1080/10428194.2017.1369063.
Chowdhry AK, et al. A Population-based Study of Prognosis and Survival in Patients With Second Primary Thyroid Cancer After Hodgkin Lymphoma. Leuk Lymphoma. 2018;59(5):1180-1187. PubMed PMID: 28862484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based study of prognosis and survival in patients with second primary thyroid cancer after Hodgkin lymphoma. AU - Chowdhry,Amit K, AU - Fung,Chunkit, AU - Chowdhry,Varun K, AU - Bergsma,Derek, AU - Dhakal,Sughosh, AU - Constine,Louis S, AU - Milano,Michael T, Y1 - 2017/09/01/ PY - 2017/9/2/pubmed PY - 2019/1/12/medline PY - 2017/9/2/entrez KW - Hodgkin lymphoma KW - Second malignancy KW - cancer survivorship KW - thyroid cancer SP - 1180 EP - 1187 JF - Leukemia & lymphoma JO - Leuk. Lymphoma VL - 59 IS - 5 N2 - Hodgkin lymphoma (HL) survivors are at increased risk of thyroid cancer (TC). We sought to determine whether increased risks of high-risk pathology or mortality are seen with thyroid cancer after HL (HL-TC) compared with first primary thyroid cancer (TC-1). From the Surveillance, Epidemiology and End Results (SEER) registry, we compared patient and tumor characteristics as well as survival outcomes between HL-TC and TC-1 and fit a multivariable Cox model to assess for a possible association between HL history and overall survival after TC. Among 139,297 TC-1 and 174 HL-TC patients, history of HL was not associated with anaplastic or sarcoma TC. Multivariable analyzes showed that history of HL was not associated with a difference in risk of death after TC (hazard ratio: 0.96, 95% confidence interval: (0.81, 1.13), p = .61). Despite a significantly increased risk of TC among HL survivors, prior HL is not associated with more aggressive pathologic subtypes or worse prognosis. SN - 1029-2403 UR - https://www.unboundmedicine.com/medline/citation/28862484/A_population_based_study_of_prognosis_and_survival_in_patients_with_second_primary_thyroid_cancer_after_Hodgkin_lymphoma_ L2 - http://www.tandfonline.com/doi/full/10.1080/10428194.2017.1369063 DB - PRIME DP - Unbound Medicine ER -