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Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine.
Drug Alcohol Depend. 2017 11 01; 180:39-45.DA

Abstract

Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA). Locomotor stimulant effects were assessed in an open-field assay for locomotor activity using Swiss-Webster mice. Discriminative stimulus effects were assessed in Sprague-Dawley rats trained to discriminate either cocaine, methamphetamine, DOM, or MDMA from vehicle. The benzofuran compounds produced locomotor stimulation whereas 4-FA depressed locomotor activity. The benzofurans substituted for the discriminative stimulus effects of MDMA, but only partially or not at all for methamphetamine, cocaine, and DOM, whereas 4-FA fully substituted for MDMA, methamphetamine and cocaine, but not DOM. These results indicate an MDMA-like pattern of abuse might be expected for the benzofurans, whereas 4-FA may be substituted for psychostimulants and MDMA.

Authors+Show Affiliations

University of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States.University of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States.University of North Texas Health Science Center, Center for Neuroscience Discovery, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. Electronic address: michael.gatch@unthsc.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28865391

Citation

Dolan, Sean B., et al. "Discriminative Stimulus and Locomotor Effects of Para-substituted and Benzofuran Analogs of Amphetamine." Drug and Alcohol Dependence, vol. 180, 2017, pp. 39-45.
Dolan SB, Forster MJ, Gatch MB. Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine. Drug Alcohol Depend. 2017;180:39-45.
Dolan, S. B., Forster, M. J., & Gatch, M. B. (2017). Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine. Drug and Alcohol Dependence, 180, 39-45. https://doi.org/10.1016/j.drugalcdep.2017.07.041
Dolan SB, Forster MJ, Gatch MB. Discriminative Stimulus and Locomotor Effects of Para-substituted and Benzofuran Analogs of Amphetamine. Drug Alcohol Depend. 2017 11 1;180:39-45. PubMed PMID: 28865391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine. AU - Dolan,Sean B, AU - Forster,Michael J, AU - Gatch,Michael B, Y1 - 2017/08/24/ PY - 2017/06/12/received PY - 2017/07/24/revised PY - 2017/07/25/accepted PY - 2017/9/3/pubmed PY - 2018/4/21/medline PY - 2017/9/3/entrez KW - Amphetamine KW - Benzofuran KW - Drug discrimination KW - Rat SP - 39 EP - 45 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 180 N2 - Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA). Locomotor stimulant effects were assessed in an open-field assay for locomotor activity using Swiss-Webster mice. Discriminative stimulus effects were assessed in Sprague-Dawley rats trained to discriminate either cocaine, methamphetamine, DOM, or MDMA from vehicle. The benzofuran compounds produced locomotor stimulation whereas 4-FA depressed locomotor activity. The benzofurans substituted for the discriminative stimulus effects of MDMA, but only partially or not at all for methamphetamine, cocaine, and DOM, whereas 4-FA fully substituted for MDMA, methamphetamine and cocaine, but not DOM. These results indicate an MDMA-like pattern of abuse might be expected for the benzofurans, whereas 4-FA may be substituted for psychostimulants and MDMA. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/28865391/Discriminative_stimulus_and_locomotor_effects_of_para_substituted_and_benzofuran_analogs_of_amphetamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(17)30427-1 DB - PRIME DP - Unbound Medicine ER -