Tags

Type your tag names separated by a space and hit enter

Population data and forensic efficiency of 21 autosomal STR loci included in AGCU EX22 amplification system in the Wanzhou Han population.
Int J Legal Med. 2018 Jan; 132(1):153-155.IJ

Abstract

Autosomal short tandem repeats (STRs), widely distributed in the whole human genome, play an important role in personal identification and parentage testing. In this study, the allele frequencies and forensic efficiency parameters of 21 autosomal STR loci included in the AGCU EX22 kit were obtained from 433 Chinese Han individuals residing in the Wanzhou District in the north of Chongqing Municipality, Southwest China. No deviation from Hardy-Weinberg equilibrium was observed in all of the 21 STR loci. A total of 241 alleles were observed with allele frequencies ranging from 0.0011 to 0.5418. The cumulative power of discrimination and the cumulative probability of exclusion were 0.9999999999999999999999999 and 0.999999996, respectively. The results of genetic distance, neighbor-joining tree, principal component plots, and multidimensional scaling analysis revealed that the Wanzhou Han had more genetic differences when compared with Kazakh and Uyghur populations from Xinjiang than other included reference populations. In summary, the results in forensic characteristic analyses indicated that the 21 STRs are highly polymorphic and can be served as a useful tool in forensic routine practices. The population comparison indicated that close geographic or ethnic origin groups had a strong genetic affinity with each other.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China. renktang2012@163.com.

MeSH

Asian Continental Ancestry GroupChinaDNA FingerprintingEthnic GroupsGene FrequencyGenetics, PopulationHumansMicrosatellite RepeatsPolymorphism, Genetic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28866789

Citation

Zou, Xing, et al. "Population Data and Forensic Efficiency of 21 Autosomal STR Loci Included in AGCU EX22 Amplification System in the Wanzhou Han Population." International Journal of Legal Medicine, vol. 132, no. 1, 2018, pp. 153-155.

Zou X, Li Y, Wei Z, et al. Population data and forensic efficiency of 21 autosomal STR loci included in AGCU EX22 amplification system in the Wanzhou Han population. Int J Legal Med. 2018;132(1):153-155.

Zou, X., Li, Y., Wei, Z., Wang, T., Hu, Y., Zhu, Y., Li, J., & Tang, R. (2018). Population data and forensic efficiency of 21 autosomal STR loci included in AGCU EX22 amplification system in the Wanzhou Han population. International Journal of Legal Medicine, 132(1), 153-155. https://doi.org/10.1007/s00414-017-1680-9

Zou X, et al. Population Data and Forensic Efficiency of 21 Autosomal STR Loci Included in AGCU EX22 Amplification System in the Wanzhou Han Population. Int J Legal Med. 2018;132(1):153-155. PubMed PMID: 28866789.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Population data and forensic efficiency of 21 autosomal STR loci included in AGCU EX22 amplification system in the Wanzhou Han population. AU - Zou,Xing, AU - Li,Yongguo, AU - Wei,Zehong, AU - Wang,Ting, AU - Hu,Yue, AU - Zhu,Ying, AU - Li,Jianbo, AU - Tang,Renkuan, Y1 - 2017/09/02/ PY - 2017/07/21/received PY - 2017/08/30/accepted PY - 2017/9/4/pubmed PY - 2018/8/17/medline PY - 2017/9/4/entrez KW - Genetic polymorphism KW - Population genetic KW - Short tandem repeat (STR) SP - 153 EP - 155 JF - International journal of legal medicine JO - Int J Legal Med VL - 132 IS - 1 N2 - Autosomal short tandem repeats (STRs), widely distributed in the whole human genome, play an important role in personal identification and parentage testing. In this study, the allele frequencies and forensic efficiency parameters of 21 autosomal STR loci included in the AGCU EX22 kit were obtained from 433 Chinese Han individuals residing in the Wanzhou District in the north of Chongqing Municipality, Southwest China. No deviation from Hardy-Weinberg equilibrium was observed in all of the 21 STR loci. A total of 241 alleles were observed with allele frequencies ranging from 0.0011 to 0.5418. The cumulative power of discrimination and the cumulative probability of exclusion were 0.9999999999999999999999999 and 0.999999996, respectively. The results of genetic distance, neighbor-joining tree, principal component plots, and multidimensional scaling analysis revealed that the Wanzhou Han had more genetic differences when compared with Kazakh and Uyghur populations from Xinjiang than other included reference populations. In summary, the results in forensic characteristic analyses indicated that the 21 STRs are highly polymorphic and can be served as a useful tool in forensic routine practices. The population comparison indicated that close geographic or ethnic origin groups had a strong genetic affinity with each other. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/28866789/Population_data_and_forensic_efficiency_of_21_autosomal_STR_loci_included_in_AGCU_EX22_amplification_system_in_the_Wanzhou_Han_population_ L2 - https://dx.doi.org/10.1007/s00414-017-1680-9 DB - PRIME DP - Unbound Medicine ER -