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High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes.
Diab Vasc Dis Res. 2017 11; 14(6):468-476.DV

Abstract

PURPOSE

The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls.

METHODS

Patients with newly diagnosed (<1 year) type 2 diabetes (n = 44) and controls (n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software.

RESULTS

Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm3; 0-50.5 mm3 vs 0; 0-34.3 mm3, p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume (τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume (p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05.

CONCLUSION

Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

Authors+Show Affiliations

1 Department of Cardiology, Hospital of Southwest Denmark, Esbjerg, Denmark.2 Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.3 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.4 Department of Cardiology, Odense University Hospital, Odense, Denmark.5 Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.6 Department of Radiology, Hospital of Southwest Denmark, Esbjerg, Denmark.3 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.7 Unit for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark. 8 Department of Clinical Biochemistry, Hospital of Southwest Denmark, Esbjerg, Denmark.9 Cardiology Section, Department of Internal Medicine, Holbæk Hospital, Holbæk, Denmark. 10 Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark.11 Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark.1 Department of Cardiology, Hospital of Southwest Denmark, Esbjerg, Denmark. 12 Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28866908

Citation

Mrgan, Monija, et al. "High Burden of Coronary Atherosclerosis in Patients With a New Diagnosis of Type 2 Diabetes." Diabetes & Vascular Disease Research, vol. 14, no. 6, 2017, pp. 468-476.
Mrgan M, Funck KL, Gaur S, et al. High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. Diab Vasc Dis Res. 2017;14(6):468-476.
Mrgan, M., Funck, K. L., Gaur, S., Øvrehus, K. A., Dey, D., Kusk, M. W., Nørgaard, B. L., Gram, J. B., Olsen, M. H., Gram, J., & Sand, N. P. R. (2017). High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. Diabetes & Vascular Disease Research, 14(6), 468-476. https://doi.org/10.1177/1479164117728014
Mrgan M, et al. High Burden of Coronary Atherosclerosis in Patients With a New Diagnosis of Type 2 Diabetes. Diab Vasc Dis Res. 2017;14(6):468-476. PubMed PMID: 28866908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. AU - Mrgan,Monija, AU - Funck,Kristian L, AU - Gaur,Sara, AU - Øvrehus,Kristian A, AU - Dey,Damini, AU - Kusk,Martin W, AU - Nørgaard,Bjarne L, AU - Gram,Jørgen B, AU - Olsen,Michael H, AU - Gram,Jeppe, AU - Sand,Niels Peter R, Y1 - 2017/09/02/ PY - 2017/9/5/pubmed PY - 2017/12/13/medline PY - 2017/9/5/entrez KW - Coronary plaque KW - coronary computed tomography KW - low-density plaque KW - type 2 diabetes SP - 468 EP - 476 JF - Diabetes & vascular disease research JO - Diab Vasc Dis Res VL - 14 IS - 6 N2 - PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls. METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes (n = 44) and controls (n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software. RESULTS: Coronary artery calcification was more often seen in patients with type 2 diabetes (66%) versus controls (48%), p < 0.05. Both the absolute volume (median; interquartile range) of low-density non-calcified plaque (7.9 mm3; 0-50.5 mm3 vs 0; 0-34.3 mm3, p < 0.05) and the increase in low-density non-calcified plaque ratio in relation to total plaque volume (τ = 0.5, p < 0.001) were significantly higher in patients with type 2 diabetes. More patients with type 2 diabetes had spotty calcification (31% vs 0%, p < 0.05). By multivariate analysis, the presence of any low-density non-calcified plaque was higher in males (odds ratio: 4.06, p < 0.05), who also demonstrated a larger low-density non-calcified plaque volume (p < 0.001). The presence and extent of low-density non-calcified plaque increased with age, smoking, hypertension and hyperglycaemia, all p < 0.05. CONCLUSION: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls. SN - 1752-8984 UR - https://www.unboundmedicine.com/medline/citation/28866908/High_burden_of_coronary_atherosclerosis_in_patients_with_a_new_diagnosis_of_type_2_diabetes_ L2 - https://journals.sagepub.com/doi/10.1177/1479164117728014?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -