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Rapid exacerbation of renal function after administration of hydroxyethyl starch in a dog.
J Vet Med Sci 2017; 79(9):1591-1595JV

Abstract

Hydroxyethyl starches (HES) are commonly used synthetic colloidal solution in veterinary medicine. Despite of possible adverse effect to kidney injury in human, there is no report about nephrotoxic effects of HES in dogs. HES was administered to a Golden retriever (4-year-old, intact male) with ascites in order to increase plasma osmolality. Initially, the dog was mild azotemic, however, kidney function was rapidly deteriorated after several days of HES administration. Finally, histopathological examination revealed remarkable osmotic nephrosis. In the case reported herein, acute kidney injury was remarkably developed after HES administration. Clinical and histopathologic findings of acute kidney injury support nephrotoxic effects of HES to a dog.

Authors+Show Affiliations

College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of Korea.College of Veterinary Medicine, Chonbuk National University, Jeonju 54896, Republic of Korea.College of Industrial Science, Kongju National University, Yesan 32439, Republic of Korea.National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of Korea.National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of Korea.Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28867687

Citation

Bae, Junwoo, et al. "Rapid Exacerbation of Renal Function After Administration of Hydroxyethyl Starch in a Dog." The Journal of Veterinary Medical Science, vol. 79, no. 9, 2017, pp. 1591-1595.
Bae J, Soliman M, Kim H, et al. Rapid exacerbation of renal function after administration of hydroxyethyl starch in a dog. J Vet Med Sci. 2017;79(9):1591-1595.
Bae, J., Soliman, M., Kim, H., Kang, S., Kim, W., Ahn, S., ... Yu, D. (2017). Rapid exacerbation of renal function after administration of hydroxyethyl starch in a dog. The Journal of Veterinary Medical Science, 79(9), pp. 1591-1595. doi:10.1292/jvms.17-0196.
Bae J, et al. Rapid Exacerbation of Renal Function After Administration of Hydroxyethyl Starch in a Dog. J Vet Med Sci. 2017 Sep 29;79(9):1591-1595. PubMed PMID: 28867687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid exacerbation of renal function after administration of hydroxyethyl starch in a dog. AU - Bae,Junwoo, AU - Soliman,Mahmoud, AU - Kim,Hyunwoo, AU - Kang,Seongwoo, AU - Kim,Woosun, AU - Ahn,Soomin, AU - Cho,Kyoungoh, AU - Choi,Jihye, AU - Kim,Suhee, AU - Park,Jinho, AU - Kim,Sangki, AU - DO,Yoonjung, AU - Yoo,Jaegyu, AU - Yu,Dohyeon, Y1 - 2017/09/02/ PY - 2017/9/5/pubmed PY - 2018/2/21/medline PY - 2017/9/5/entrez KW - acute kidney injury KW - dog KW - hydroxyethyl starch KW - osmotic nephrosis SP - 1591 EP - 1595 JF - The Journal of veterinary medical science JO - J. Vet. Med. Sci. VL - 79 IS - 9 N2 - Hydroxyethyl starches (HES) are commonly used synthetic colloidal solution in veterinary medicine. Despite of possible adverse effect to kidney injury in human, there is no report about nephrotoxic effects of HES in dogs. HES was administered to a Golden retriever (4-year-old, intact male) with ascites in order to increase plasma osmolality. Initially, the dog was mild azotemic, however, kidney function was rapidly deteriorated after several days of HES administration. Finally, histopathological examination revealed remarkable osmotic nephrosis. In the case reported herein, acute kidney injury was remarkably developed after HES administration. Clinical and histopathologic findings of acute kidney injury support nephrotoxic effects of HES to a dog. SN - 1347-7439 UR - https://www.unboundmedicine.com/medline/citation/28867687/Rapid_exacerbation_of_renal_function_after_administration_of_hydroxyethyl_starch_in_a_dog_ L2 - https://dx.doi.org/10.1292/jvms.17-0196 DB - PRIME DP - Unbound Medicine ER -