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[Data mining analysis of regularity of formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos medicin pair in Dictionary of Chinese Medicine Prescription].
Zhongguo Zhong Yao Za Zhi. 2016 Feb; 41(3):528-531.ZZ

Abstract

In this study, formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos in the database of Dictionary of Chinese Medicine Prescription (DCMP) were extracted by using traditional Chinese medicine inheritance support system (TCMISS). The drugs pairs and formula composition rules were analyzed with data mining methods, such as association rules, improved mutual information method and complex system entropy clustering. Totally 39 formulas were included in this study and involved 280 Chinese medicines. The top 5 Chinese medicines most frequently used were Danggui (Angelica sinensis), Chuanxiong (Ligusticum chuanxiong), Xiangfu (Cyperi Rhizoma), Baishao(Radix Paeoniae Alba), Taoren(Prunus persica) and Shengdihuang (Radix Rehmanniae Recens). Six core medicinal pairs were obtained through clustering analysis, namely Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Xiangfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Xiagnfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Honghua (Carthami Flos)-Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Danggui (A. sinensis), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos)-Danggui (A. sinensis). The support degree was set at 11 (38.46%), with a confidence coefficient of 80%, and then 38 associated pairs were screened. These results suggested that Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos is often combined with herbs for activating blood and promoting circulation of qi to treat gynecopathy, stasis blood pain syndrome, stroke and other syndromes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Cui YR
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Liu X
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Shen D
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Yang HJ
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Tang SH
Institute of Chinese Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

MeSH

CarthamusData MiningDrug CompoundingDrug PrescriptionsDrug TherapyDrugs, Chinese HerbalFlowersHumansMedicine in LiteratureMedicine, Chinese TraditionalRhizomeSalvia miltiorrhiza

Pub Type(s)

Journal Article

Language

chi

PubMed ID

28868875

Citation

Cui, Yi-Ran, et al. "[Data Mining Analysis of Regularity of Formulas Containing Salviae Miltiorrhizae Radix Et Rhizoma-Carthami Flos Medicin Pair in Dictionary of Chinese Medicine Prescription]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 41, no. 3, 2016, pp. 528-531.
Cui YR, Liu X, Shen D, et al. [Data mining analysis of regularity of formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos medicin pair in Dictionary of Chinese Medicine Prescription]. Zhongguo Zhong Yao Za Zhi. 2016;41(3):528-531.
Cui, Y. R., Liu, X., Shen, D., Yang, H. J., & Tang, S. H. (2016). [Data mining analysis of regularity of formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos medicin pair in Dictionary of Chinese Medicine Prescription]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 41(3), 528-531. https://doi.org/10.4268/cjcmm20160328
Cui YR, et al. [Data Mining Analysis of Regularity of Formulas Containing Salviae Miltiorrhizae Radix Et Rhizoma-Carthami Flos Medicin Pair in Dictionary of Chinese Medicine Prescription]. Zhongguo Zhong Yao Za Zhi. 2016;41(3):528-531. PubMed PMID: 28868875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Data mining analysis of regularity of formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos medicin pair in Dictionary of Chinese Medicine Prescription]. AU - Cui,Yi-Ran, AU - Liu,Xin, AU - Shen,Dan, AU - Yang,Hong-Jun, AU - Tang,Shi-Huan, PY - 2015/07/21/received PY - 2017/9/5/entrez PY - 2016/2/1/pubmed PY - 2016/2/1/medline KW - Carthami Flos KW - Dictionary of Chinese Medicine Prescription KW - Salviae Miltiorrhizae Radix et Rhizoma KW - data mining KW - medication regularity KW - medicine pair KW - traditional Chinese medicine inheritance support system SP - 528 EP - 531 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 41 IS - 3 N2 - In this study, formulas containing Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos in the database of Dictionary of Chinese Medicine Prescription (DCMP) were extracted by using traditional Chinese medicine inheritance support system (TCMISS). The drugs pairs and formula composition rules were analyzed with data mining methods, such as association rules, improved mutual information method and complex system entropy clustering. Totally 39 formulas were included in this study and involved 280 Chinese medicines. The top 5 Chinese medicines most frequently used were Danggui (Angelica sinensis), Chuanxiong (Ligusticum chuanxiong), Xiangfu (Cyperi Rhizoma), Baishao(Radix Paeoniae Alba), Taoren(Prunus persica) and Shengdihuang (Radix Rehmanniae Recens). Six core medicinal pairs were obtained through clustering analysis, namely Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Xiangfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Xiagnfu (Cyperi Rhizoma)-Honghua (Carthami Flos), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Danggui (A. sinensis)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos), Honghua (Carthami Flos)-Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Danggui (A. sinensis), Danshen (Salviae Miltiorrhizae Radix et Rhizoma)-Baishao (Radix Paeoniae Alba)-Honghua (Carthami Flos)-Danggui (A. sinensis). The support degree was set at 11 (38.46%), with a confidence coefficient of 80%, and then 38 associated pairs were screened. These results suggested that Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos is often combined with herbs for activating blood and promoting circulation of qi to treat gynecopathy, stasis blood pain syndrome, stroke and other syndromes. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/28868875/[Data_mining_analysis_of_regularity_of_formulas_containing_Salviae_Miltiorrhizae_Radix_et_Rhizoma_Carthami_Flos_medicin_pair_in_Dictionary_of_Chinese_Medicine_Prescription]_ DB - PRIME DP - Unbound Medicine ER -