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Energy expenditure, body composition, and prevalence of metabolic disorders in patients with Duchenne muscular dystrophy.
Diabetes Metab Syndr. 2018 Apr - Jun; 12(2):81-85.DM

Abstract

INTRODUCTION

Duchenne muscular dystrophy (DMD) is a severe muscular disease characterized by progressive loss of functional muscle mass followed by changes in body composition.

AIM

To describe body composition, resting energy expenditure (REE), and metabolic disorders in DMD patients followed-up at a tertiary care center. To analyze the association with type of steroid and ambulatory status, and to compare obese DMD patients with patients with multifactorial obesity.

POPULATION AND METHODS

A prospective, observational, cross-sectional study was conducted. Anthropometric measurements were taken, evaluating body composition with bioelectrical impedance analysis (BIA), REE with indirect calorimetry, and biochemical parameters in all DMD patients seen between June 2013 and April 2014.

RESULTS

63 boys between 5.4 and 18.7years of age were evaluated. Diagnosis of obesity ranged from 28% measuring body mass indexZ-score (BMIZ-score) to 70% using percentage of fat mass (%FM). Patients who had lost gait had a significantly higher %FM than those in whom gait was preserved (72% vs 46%, p<0.05). Insulin resistance was present in 29% associated with BMI Z-score and waist circumference and 40% had dyslipidemia associated with %FM, both of which were steroid independent. In obese DMD patients REE was lower than predicted and also lower than controls, and persist when dividing the patients into ambulators and non-ambulators.

CONCLUSIONS

A high prevalence of obesity was observed. BMI-Z-score underestimates the degree of FM. No correlation was found between steroid type and body composition or metabolic disorders. No differences were found in REE between ambulators and non-ambulators. Obese DMD patients have a lower REE than controls.

Authors+Show Affiliations

Department of Nutrition and Diabetes, Hospital JP Garrahan, Argentina. Electronic address: gocarola@fibertel.com.ar.Department of Nutrition and Diabetes, Hospital JP Garrahan, Argentina. Electronic address: carocaminiti@gmail.com.Department of Nutrition and Diabetes, Hospital JP Garrahan, Argentina. Electronic address: julietaweglinski@gmail.com.Head of Day Hospital, Hospital J P Garrahan, Argentina. Electronic address: mariferdc@gmail.com.Department of Neurology, Hospital J P Garrahan, Argentina. Electronic address: mmonges@intramed.net.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28869151

Citation

Saure, Carola, et al. "Energy Expenditure, Body Composition, and Prevalence of Metabolic Disorders in Patients With Duchenne Muscular Dystrophy." Diabetes & Metabolic Syndrome, vol. 12, no. 2, 2018, pp. 81-85.
Saure C, Caminiti C, Weglinski J, et al. Energy expenditure, body composition, and prevalence of metabolic disorders in patients with Duchenne muscular dystrophy. Diabetes Metab Syndr. 2018;12(2):81-85.
Saure, C., Caminiti, C., Weglinski, J., de Castro Perez, F., & Monges, S. (2018). Energy expenditure, body composition, and prevalence of metabolic disorders in patients with Duchenne muscular dystrophy. Diabetes & Metabolic Syndrome, 12(2), 81-85. https://doi.org/10.1016/j.dsx.2017.08.006
Saure C, et al. Energy Expenditure, Body Composition, and Prevalence of Metabolic Disorders in Patients With Duchenne Muscular Dystrophy. Diabetes Metab Syndr. 2018 Apr - Jun;12(2):81-85. PubMed PMID: 28869151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Energy expenditure, body composition, and prevalence of metabolic disorders in patients with Duchenne muscular dystrophy. AU - Saure,Carola, AU - Caminiti,Carolina, AU - Weglinski,Julieta, AU - de Castro Perez,Fernanda, AU - Monges,Soledad, Y1 - 2017/08/26/ PY - 2017/08/02/received PY - 2017/08/20/accepted PY - 2017/9/5/pubmed PY - 2018/9/25/medline PY - 2017/9/5/entrez KW - Baseline energy expenditure KW - Bioelectrical impedance analysis KW - Body composition KW - Duchenne muscular dystrophy KW - Indirect calorimetry SP - 81 EP - 85 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 12 IS - 2 N2 - INTRODUCTION: Duchenne muscular dystrophy (DMD) is a severe muscular disease characterized by progressive loss of functional muscle mass followed by changes in body composition. AIM: To describe body composition, resting energy expenditure (REE), and metabolic disorders in DMD patients followed-up at a tertiary care center. To analyze the association with type of steroid and ambulatory status, and to compare obese DMD patients with patients with multifactorial obesity. POPULATION AND METHODS: A prospective, observational, cross-sectional study was conducted. Anthropometric measurements were taken, evaluating body composition with bioelectrical impedance analysis (BIA), REE with indirect calorimetry, and biochemical parameters in all DMD patients seen between June 2013 and April 2014. RESULTS: 63 boys between 5.4 and 18.7years of age were evaluated. Diagnosis of obesity ranged from 28% measuring body mass indexZ-score (BMIZ-score) to 70% using percentage of fat mass (%FM). Patients who had lost gait had a significantly higher %FM than those in whom gait was preserved (72% vs 46%, p<0.05). Insulin resistance was present in 29% associated with BMI Z-score and waist circumference and 40% had dyslipidemia associated with %FM, both of which were steroid independent. In obese DMD patients REE was lower than predicted and also lower than controls, and persist when dividing the patients into ambulators and non-ambulators. CONCLUSIONS: A high prevalence of obesity was observed. BMI-Z-score underestimates the degree of FM. No correlation was found between steroid type and body composition or metabolic disorders. No differences were found in REE between ambulators and non-ambulators. Obese DMD patients have a lower REE than controls. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/28869151/Energy_expenditure_body_composition_and_prevalence_of_metabolic_disorders_in_patients_with_Duchenne_muscular_dystrophy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(17)30276-X DB - PRIME DP - Unbound Medicine ER -