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Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China.
J Glob Antimicrob Resist. 2017 12; 11:183-187.JG

Abstract

OBJECTIVES

There is a lack of information on the activities of antimicrobial agents against Nocardia clinical isolates of specific species in China. The aim of this study was to determine the antibiotic susceptibility of 28 clinical isolates of Nocardia spp. isolated from Beijing Chao-Yang Hospital (Beijing, China).

METHODS

Molecular diagnosis of Nocardia spp. was performed using partial 16S rRNA and rpoB gene sequences. Antimicrobial susceptibility testing was performed by broth microdilution according to Clinical and Laboratory Standards Institute (CLSI) recommendations.

RESULTS

The species distribution was as follows: Nocardia cyriacigeorgica (n=13); Nocardia farcinica (n=6); Nocardia beijingensis (n=3); Nocardia abscessus (n=2); Nocardia wallacei (n=2); Nocardia otitidiscaviarum (n=1); and Nocardia nova (n=1). The susceptibility rates to trimethoprim/sulfamethoxazole (SXT), linezolid, amikacin, imipenem, tobramycin, ceftriaxone and cefotaxime were 100.0%, 100.0%, 92.9%, 75.0%, 67.9%, 67.9% and 64.3%, respectively, whilst the resistance rate both to ciprofloxacin and clarithromycin was 71.4%.

CONCLUSIONS

N. cyriacigeorgica was the most frequently isolated Nocardia spp. All clinical isolates showed low susceptibility to ciprofloxacin and clarithromycin and complete susceptibility both to SXT and linezolid, which can be considered the primary choice for the treatment of Nocardia infections in China.

Authors+Show Affiliations

Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address: 13241759989@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28870771

Citation

Wei, Ming, et al. "Identification and Antimicrobial Susceptibility of Clinical Nocardia Species in a Tertiary Hospital in China." Journal of Global Antimicrobial Resistance, vol. 11, 2017, pp. 183-187.
Wei M, Wang P, Qu J, et al. Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China. J Glob Antimicrob Resist. 2017;11:183-187.
Wei, M., Wang, P., Qu, J., Li, R., Liu, Y., Gu, L., & Yang, C. (2017). Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China. Journal of Global Antimicrobial Resistance, 11, 183-187. https://doi.org/10.1016/j.jgar.2017.08.011
Wei M, et al. Identification and Antimicrobial Susceptibility of Clinical Nocardia Species in a Tertiary Hospital in China. J Glob Antimicrob Resist. 2017;11:183-187. PubMed PMID: 28870771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification and antimicrobial susceptibility of clinical Nocardia species in a tertiary hospital in China. AU - Wei,Ming, AU - Wang,Peng, AU - Qu,Jiuxin, AU - Li,Ran, AU - Liu,Yongzhe, AU - Gu,Li, AU - Yang,Chunxia, Y1 - 2017/09/01/ PY - 2017/07/04/received PY - 2017/08/22/revised PY - 2017/08/23/accepted PY - 2017/9/6/pubmed PY - 2019/6/20/medline PY - 2017/9/6/entrez KW - 16S Rrna KW - China KW - Drug pattern KW - Nocardia KW - Susceptibility KW - rpoB SP - 183 EP - 187 JF - Journal of global antimicrobial resistance JO - J Glob Antimicrob Resist VL - 11 N2 - OBJECTIVES: There is a lack of information on the activities of antimicrobial agents against Nocardia clinical isolates of specific species in China. The aim of this study was to determine the antibiotic susceptibility of 28 clinical isolates of Nocardia spp. isolated from Beijing Chao-Yang Hospital (Beijing, China). METHODS: Molecular diagnosis of Nocardia spp. was performed using partial 16S rRNA and rpoB gene sequences. Antimicrobial susceptibility testing was performed by broth microdilution according to Clinical and Laboratory Standards Institute (CLSI) recommendations. RESULTS: The species distribution was as follows: Nocardia cyriacigeorgica (n=13); Nocardia farcinica (n=6); Nocardia beijingensis (n=3); Nocardia abscessus (n=2); Nocardia wallacei (n=2); Nocardia otitidiscaviarum (n=1); and Nocardia nova (n=1). The susceptibility rates to trimethoprim/sulfamethoxazole (SXT), linezolid, amikacin, imipenem, tobramycin, ceftriaxone and cefotaxime were 100.0%, 100.0%, 92.9%, 75.0%, 67.9%, 67.9% and 64.3%, respectively, whilst the resistance rate both to ciprofloxacin and clarithromycin was 71.4%. CONCLUSIONS: N. cyriacigeorgica was the most frequently isolated Nocardia spp. All clinical isolates showed low susceptibility to ciprofloxacin and clarithromycin and complete susceptibility both to SXT and linezolid, which can be considered the primary choice for the treatment of Nocardia infections in China. SN - 2213-7173 UR - https://www.unboundmedicine.com/medline/citation/28870771/Identification_and_antimicrobial_susceptibility_of_clinical_Nocardia_species_in_a_tertiary_hospital_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-7165(17)30158-3 DB - PRIME DP - Unbound Medicine ER -