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Association between metabolic syndrome and intravesical prostatic protrusion in patients with benign prostatic enlargement and lower urinary tract symptoms (MIPS Study).
BJU Int. 2018 05; 121(5):799-804.BI

Abstract

OBJECTIVE

To investigate the association between metabolic syndrome (MetS) and morphological features of benign prostatic enlargement (BPE), including total prostate volume (TPV), transitional zone volume (TZV) and intravesical prostatic protrusion (IPP).

PATIENTS AND METHODS

Between January 2015 and January 2017, 224 consecutive men aged >50 years presenting with lower urinary tract symptoms (LUTS) suggestive of BPE were recruited to this multicentre cross-sectional study. MetS was defined according to International Diabetes Federation criteria. Multivariate linear and logistic regression models were performed to verify factors associated with IPP, TZV and TPV.

RESULTS

Patients with MetS were observed to have a significant increase in IPP (P < 0.01), TPV (P < 0.01) and TZV (P = 0.02). On linear regression analysis, adjusted for age and metabolic factors of MetS, we found that high-density lipoprotein (HDL) cholesterol was negatively associated with IPP (r = -0.17), TPV (r = -0.19) and TZV (r = -0.17), while hypertension was positively associated with IPP (r = 0.16), TPV (r = 0.19) and TZV (r = 0.16). On multivariate logistic regression analysis adjusted for age and factors of MetS, hypertension (categorical; odds ratio [OR] 2.95), HDL cholesterol (OR 0.94) and triglycerides (OR 1.01) were independent predictors of TPV ≥ 40 mL. We also found that HDL cholesterol (OR 0.86), hypertension (OR 2.0) and waist circumference (OR 1.09) were significantly associated with TZV ≥ 20 mL. On age-adjusted logistic regression analysis, MetS was significantly associated with IPP ≥ 10 mm (OR 34.0; P < 0.01), TZV ≥ 20 mL (OR 4.40; P < 0.01) and TPV ≥ 40 mL (OR 5.89; P = 0.03).

CONCLUSION

We found an association between MetS and BPE, demonstrating a relationship with IPP.

Authors+Show Affiliations

Urology Section, Department of Surgery, University of Catania, Catania, Italy.Urology Section, Department of Surgery, University of Catania, Catania, Italy.Department of Urology, University of Florence, Florence, Italy.Department of Urology, University of Florence, Florence, Italy.Urology Section, Department of Surgery, University of Catania, Catania, Italy.Urology Section, Department of Surgery, University of Catania, Catania, Italy.Department of Urology, University of Florence, Florence, Italy.Department of Urology, University of Florence, Florence, Italy.Department of Urology, University of Florence, Florence, Italy.Urology Section, Department of Surgery, University of Catania, Catania, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28872764

Citation

Russo, Giorgio I., et al. "Association Between Metabolic Syndrome and Intravesical Prostatic Protrusion in Patients With Benign Prostatic Enlargement and Lower Urinary Tract Symptoms (MIPS Study)." BJU International, vol. 121, no. 5, 2018, pp. 799-804.
Russo GI, Regis F, Spatafora P, et al. Association between metabolic syndrome and intravesical prostatic protrusion in patients with benign prostatic enlargement and lower urinary tract symptoms (MIPS Study). BJU Int. 2018;121(5):799-804.
Russo, G. I., Regis, F., Spatafora, P., Frizzi, J., Urzì, D., Cimino, S., Serni, S., Carini, M., Gacci, M., & Morgia, G. (2018). Association between metabolic syndrome and intravesical prostatic protrusion in patients with benign prostatic enlargement and lower urinary tract symptoms (MIPS Study). BJU International, 121(5), 799-804. https://doi.org/10.1111/bju.14007
Russo GI, et al. Association Between Metabolic Syndrome and Intravesical Prostatic Protrusion in Patients With Benign Prostatic Enlargement and Lower Urinary Tract Symptoms (MIPS Study). BJU Int. 2018;121(5):799-804. PubMed PMID: 28872764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between metabolic syndrome and intravesical prostatic protrusion in patients with benign prostatic enlargement and lower urinary tract symptoms (MIPS Study). AU - Russo,Giorgio I, AU - Regis,Federica, AU - Spatafora,Pietro, AU - Frizzi,Jacopo, AU - Urzì,Daniele, AU - Cimino,Sebastiano, AU - Serni,Sergio, AU - Carini,Marco, AU - Gacci,Mauro, AU - Morgia,Giuseppe, Y1 - 2017/09/28/ PY - 2017/9/6/pubmed PY - 2019/2/12/medline PY - 2017/9/6/entrez KW - benign prostatic enlargement KW - intravesical prostatic protrusion KW - lower urinary tract symptoms KW - metabolic syndrome KW - prostate volume SP - 799 EP - 804 JF - BJU international JO - BJU Int VL - 121 IS - 5 N2 - OBJECTIVE: To investigate the association between metabolic syndrome (MetS) and morphological features of benign prostatic enlargement (BPE), including total prostate volume (TPV), transitional zone volume (TZV) and intravesical prostatic protrusion (IPP). PATIENTS AND METHODS: Between January 2015 and January 2017, 224 consecutive men aged >50 years presenting with lower urinary tract symptoms (LUTS) suggestive of BPE were recruited to this multicentre cross-sectional study. MetS was defined according to International Diabetes Federation criteria. Multivariate linear and logistic regression models were performed to verify factors associated with IPP, TZV and TPV. RESULTS: Patients with MetS were observed to have a significant increase in IPP (P < 0.01), TPV (P < 0.01) and TZV (P = 0.02). On linear regression analysis, adjusted for age and metabolic factors of MetS, we found that high-density lipoprotein (HDL) cholesterol was negatively associated with IPP (r = -0.17), TPV (r = -0.19) and TZV (r = -0.17), while hypertension was positively associated with IPP (r = 0.16), TPV (r = 0.19) and TZV (r = 0.16). On multivariate logistic regression analysis adjusted for age and factors of MetS, hypertension (categorical; odds ratio [OR] 2.95), HDL cholesterol (OR 0.94) and triglycerides (OR 1.01) were independent predictors of TPV ≥ 40 mL. We also found that HDL cholesterol (OR 0.86), hypertension (OR 2.0) and waist circumference (OR 1.09) were significantly associated with TZV ≥ 20 mL. On age-adjusted logistic regression analysis, MetS was significantly associated with IPP ≥ 10 mm (OR 34.0; P < 0.01), TZV ≥ 20 mL (OR 4.40; P < 0.01) and TPV ≥ 40 mL (OR 5.89; P = 0.03). CONCLUSION: We found an association between MetS and BPE, demonstrating a relationship with IPP. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/28872764/Association_between_metabolic_syndrome_and_intravesical_prostatic_protrusion_in_patients_with_benign_prostatic_enlargement_and_lower_urinary_tract_symptoms__MIPS_Study__ L2 - https://doi.org/10.1111/bju.14007 DB - PRIME DP - Unbound Medicine ER -