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Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus.
Horm Res. 1987; 27(1):7-12.HR

Abstract

The effect of a new long-acting somatostatin analog SMS 201-995 (SMS) on hormonal mechanisms controlling the glucose metabolism was tested in 8 type I diabetics over a 3-day period. In addition to dietary measures and conventional insulin therapy, the patients received a subcutaneous dose of 50 micrograms SMS three times daily for 3 days. Serum growth hormone (GH) was measured at various intervals throughout the investigational period. Glucagon, somatomedin C (SM-C), triiodothyronine, thyroxine, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) were also determined before and at the end of the therapy with SMS. Basal GH and plasma SM-C had decreased significantly (p less than 0.05 and p less than 0.01, respectively) by the 3rd day. In all cases the insulin requirements could be reduced (mean 28%) without deterioration of the metabolic control. Moreover, blood glucose profiles showed a tendency to lower postprandial peaks after SMS treatment. Glucagon, triiodothyronine, thyroxine, LH, FSH and PRL showed no significant changes. No side effects or alterations in laboratory chemistries were recorded. Dampening of glucose oscillations and counterregulatory mechanisms, and reduction of insulin dosage by SMS may enable a better control of unstable diabetes. Its slow plasma clearance and long action compared to the native peptide will warrant the use of this analog as a additive to standard diabetes therapy in more prolonged trials.

Authors

Plewe G
No affiliation info available
Noelken G
No affiliation info available
Krause U
No affiliation info available
Beyer J
No affiliation info available
del Pozo E
No affiliation info available

MeSH

AdultDiabetes Mellitus, Type 1Diabetic RetinopathyFemaleGrowth HormoneHumansInsulin-Like Growth Factor IMaleMiddle AgedOctreotideSomatomedinsSomatostatin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2887504

Citation

Plewe, G, et al. "Suppression of Growth Hormone and Somatomedin C By Long-acting Somatostatin Analog SMS 201-995 in Type I Diabetes Mellitus." Hormone Research, vol. 27, no. 1, 1987, pp. 7-12.
Plewe G, Noelken G, Krause U, et al. Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus. Horm Res. 1987;27(1):7-12.
Plewe, G., Noelken, G., Krause, U., Beyer, J., & del Pozo, E. (1987). Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus. Hormone Research, 27(1), 7-12.
Plewe G, et al. Suppression of Growth Hormone and Somatomedin C By Long-acting Somatostatin Analog SMS 201-995 in Type I Diabetes Mellitus. Horm Res. 1987;27(1):7-12. PubMed PMID: 2887504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus. AU - Plewe,G, AU - Noelken,G, AU - Krause,U, AU - Beyer,J, AU - del Pozo,E, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 7 EP - 12 JF - Hormone research JO - Horm Res VL - 27 IS - 1 N2 - The effect of a new long-acting somatostatin analog SMS 201-995 (SMS) on hormonal mechanisms controlling the glucose metabolism was tested in 8 type I diabetics over a 3-day period. In addition to dietary measures and conventional insulin therapy, the patients received a subcutaneous dose of 50 micrograms SMS three times daily for 3 days. Serum growth hormone (GH) was measured at various intervals throughout the investigational period. Glucagon, somatomedin C (SM-C), triiodothyronine, thyroxine, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) were also determined before and at the end of the therapy with SMS. Basal GH and plasma SM-C had decreased significantly (p less than 0.05 and p less than 0.01, respectively) by the 3rd day. In all cases the insulin requirements could be reduced (mean 28%) without deterioration of the metabolic control. Moreover, blood glucose profiles showed a tendency to lower postprandial peaks after SMS treatment. Glucagon, triiodothyronine, thyroxine, LH, FSH and PRL showed no significant changes. No side effects or alterations in laboratory chemistries were recorded. Dampening of glucose oscillations and counterregulatory mechanisms, and reduction of insulin dosage by SMS may enable a better control of unstable diabetes. Its slow plasma clearance and long action compared to the native peptide will warrant the use of this analog as a additive to standard diabetes therapy in more prolonged trials. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/2887504/Suppression_of_growth_hormone_and_somatomedin_C_by_long_acting_somatostatin_analog_SMS_201_995_in_type_I_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -