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[Analysis of commercial specifications and grades of wild and cultivated Gentianae Macrophyllae Radix based on multi-indicative constituents].
Zhongguo Zhong Yao Za Zhi. 2016 Mar; 41(5):786-792.ZZ

Abstract

The study is aimed to analyze the commercial specifications and grades of wild and cultivated Gentianae Macrophllae Radix based on multi-indicative constituents. The seven kinds of main chemical components containing in Gentianae Macrophyllae Radix were determined by UPLC, and then the quality levels of chemical component of Gentianae Macrophyllae Radix were clustered and classified by modern statistical methods (canonical correspondence analysis, Fisher discriminant analysis and so on). The quality indices were selected and their correlations were analyzed. Lastly, comprehensively quantitative grade division for quality under different commodity-specifications and different grades of same commodity-specifications of wild and planting were divided. The results provide a basis for a reasonable division of specification and grade of the commodity of Gentianae Macrophyllae Radix. The range of quality evaluation of main index components (gentiopicrin, loganin acid and swertiamarin) was proposed, and the Herbal Quality Index (HQI) was introduced. The rank discriminant function was established based on the quality by Fisher discriminant analysis. According to the analysis, the quality of wild and cultivated Luobojiao, one of the commercial specification of Gentianae Macrophyllae Radix was the best, Mahuajiao, the other commercial specification, was average , Xiaoqinjiao was inferior. Among grades, the quality of first-class cultivated Luobojiao was the worst, of second class secondary, and the third class the best; The quality of the first-class of wild Luobojiao was secondary, and the second-class the best; The quality of the second-class of Mahuajiao was secondary, and the first-class was the best; the quality of first-class Xiaoqinjiao was secondary, and the second-class was the better one between the two grades, but not obvious significantly. The method provides a new idea and method for evaluation of comprehensively quantitative on the quality of Gentianae Macrophyllae Radix.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yang YM
Gansu University of Chinese Medicine, Lanzhou 730000, China.
Lin L
Gansu University of Chinese Medicine, Lanzhou 730000, China. Research Institute of Chinese （Tibetan） Medicinal Resources, Lanzhou 730000, China.
Lu YY
Gansu University of Chinese Medicine, Lanzhou 730000, China.
Ma XH
Gansu University of Chinese Medicine, Lanzhou 730000, China.
Jin L
Gansu University of Chinese Medicine, Lanzhou 730000, China. Research Institute of Chinese （Tibetan） Medicinal Resources, Lanzhou 730000, China.
Zhu TT
Gansu University of Chinese Medicine, Lanzhou 730000, China. Research Institute of Chinese （Tibetan） Medicinal Resources, Lanzhou 730000, China.

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalGentianaIridoid GlucosidesPyronesQuality Control

Pub Type(s)

Journal Article

Language

chi

PubMed ID

28875628

Citation

Yang, Yan-Mei, et al. "[Analysis of Commercial Specifications and Grades of Wild and Cultivated Gentianae Macrophyllae Radix Based On Multi-indicative Constituents]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 41, no. 5, 2016, pp. 786-792.
Yang YM, Lin L, Lu YY, et al. [Analysis of commercial specifications and grades of wild and cultivated Gentianae Macrophyllae Radix based on multi-indicative constituents]. Zhongguo Zhong Yao Za Zhi. 2016;41(5):786-792.
Yang, Y. M., Lin, L., Lu, Y. Y., Ma, X. H., Jin, L., & Zhu, T. T. (2016). [Analysis of commercial specifications and grades of wild and cultivated Gentianae Macrophyllae Radix based on multi-indicative constituents]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 41(5), 786-792. https://doi.org/10.4268/cjcmm20160505
Yang YM, et al. [Analysis of Commercial Specifications and Grades of Wild and Cultivated Gentianae Macrophyllae Radix Based On Multi-indicative Constituents]. Zhongguo Zhong Yao Za Zhi. 2016;41(5):786-792. PubMed PMID: 28875628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of commercial specifications and grades of wild and cultivated Gentianae Macrophyllae Radix based on multi-indicative constituents]. AU - Yang,Yan-Mei, AU - Lin,Li, AU - Lu,You-Yuan, AU - Ma,Xiao-Hui, AU - Jin,Ling, AU - Zhu,Tian-Tian, PY - 2015/06/17/received PY - 2017/9/7/entrez PY - 2016/3/1/pubmed PY - 2016/3/1/medline KW - Gentianae Macrophyllae Radix KW - UPLC KW - commercial specification and grade KW - crude drug KW - multiple indicative constituents SP - 786 EP - 792 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 41 IS - 5 N2 - The study is aimed to analyze the commercial specifications and grades of wild and cultivated Gentianae Macrophllae Radix based on multi-indicative constituents. The seven kinds of main chemical components containing in Gentianae Macrophyllae Radix were determined by UPLC, and then the quality levels of chemical component of Gentianae Macrophyllae Radix were clustered and classified by modern statistical methods (canonical correspondence analysis, Fisher discriminant analysis and so on). The quality indices were selected and their correlations were analyzed. Lastly, comprehensively quantitative grade division for quality under different commodity-specifications and different grades of same commodity-specifications of wild and planting were divided. The results provide a basis for a reasonable division of specification and grade of the commodity of Gentianae Macrophyllae Radix. The range of quality evaluation of main index components (gentiopicrin, loganin acid and swertiamarin) was proposed, and the Herbal Quality Index (HQI) was introduced. The rank discriminant function was established based on the quality by Fisher discriminant analysis. According to the analysis, the quality of wild and cultivated Luobojiao, one of the commercial specification of Gentianae Macrophyllae Radix was the best, Mahuajiao, the other commercial specification, was average , Xiaoqinjiao was inferior. Among grades, the quality of first-class cultivated Luobojiao was the worst, of second class secondary, and the third class the best; The quality of the first-class of wild Luobojiao was secondary, and the second-class the best; The quality of the second-class of Mahuajiao was secondary, and the first-class was the best; the quality of first-class Xiaoqinjiao was secondary, and the second-class was the better one between the two grades, but not obvious significantly. The method provides a new idea and method for evaluation of comprehensively quantitative on the quality of Gentianae Macrophyllae Radix. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/28875628/[Analysis_of_commercial_specifications_and_grades_of_wild_and_cultivated_Gentianae_Macrophyllae_Radix_based_on_multi_indicative_constituents]_ DB - PRIME DP - Unbound Medicine ER -