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In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children.
Br J Nutr. 2017 Aug; 118(4):273-279.BJ

Abstract

Fe fortification of wheat flour was proposed in Haiti to combat Fe deficiency, but Fe bioavailability from fortificants has never been investigated in Haitian women or preschool children, two key target groups. We aimed to investigate the bioavailability of ferrous fumarate (FeFum), NaFeEDTA and their combination from fortified wheat flour. We recruited twenty-two healthy mother-child pairs in Port au Prince, Haiti, for an Fe-absorption study. We administered stable Fe isotopes as FeFum or NaFeEDTA individually in low-extraction wheat flour bread rolls consumed by all participants in a randomised, cross-over design. In a final, identical meal, consumed only by the women, FeFum+NaFeEDTA was administered. We measured Fe absorption by using erythrocyte incorporation of stable isotopes 14 d after consumption of each meal, and determined Fe status, inflammatory markers and Helicobacter pylori infection. Fe absorption (geometric mean was 9·24 (95 % CI 6·35, 13·44) and 9·26 (95 % CI 7·00, 12·31) from FeFum and 13·06 (95 % CI 9·23, 19·10) and 12·99 (95 % CI 9·18, 18·39) from NaFeEDTA in mothers and children, respectively (P<0·05 between compounds). Fe absorption from FeFum+NaFeEDTA was 11·09 (95 % CI 7·45, 17·34) and did not differ from the other two meals. H. pylori infection did not influence Fe absorption in children. In conclusion, in Haitian women and children, Fe absorption from NaFeEDTA was 40 % higher than from FeFum, and the combination FeFum+NaFeEDTA did not significantly increase Fe absorption compared with FeFum alone. In the context of Haiti, where the high costs of NaFeEDTA may not be affordable, the use of FeFum at 60 mg Fe/kg flour may be a preferable, cost-effective fortification strategy.

Authors+Show Affiliations

1Laboratory of Human Nutrition,ETH Zurich,8092 Zurich,Switzerland.2Ministère de la Santé Publique et de la Population,HT 6110 Port au Prince,Haiti.3Laboratoire Nationale de la Santé,HT 6110 Port au Prince,Haiti.4International Atomic Energy Agency,1400 Vienna,Austria.2Ministère de la Santé Publique et de la Population,HT 6110 Port au Prince,Haiti.1Laboratory of Human Nutrition,ETH Zurich,8092 Zurich,Switzerland.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28875866

Citation

Herter-Aeberli, Isabelle, et al. "In Haitian Women and Preschool Children, Iron Absorption From Wheat Flour-based Meals Fortified With Sodium Iron EDTA Is Higher Than That From Meals Fortified With Ferrous Fumarate, and Is Not Affected By Helicobacter Pylori Infection in Children." The British Journal of Nutrition, vol. 118, no. 4, 2017, pp. 273-279.
Herter-Aeberli I, Eliancy K, Rathon Y, et al. In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children. Br J Nutr. 2017;118(4):273-279.
Herter-Aeberli, I., Eliancy, K., Rathon, Y., Loechl, C. U., Marhône Pierre, J., & Zimmermann, M. B. (2017). In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children. The British Journal of Nutrition, 118(4), 273-279. https://doi.org/10.1017/S0007114517002045
Herter-Aeberli I, et al. In Haitian Women and Preschool Children, Iron Absorption From Wheat Flour-based Meals Fortified With Sodium Iron EDTA Is Higher Than That From Meals Fortified With Ferrous Fumarate, and Is Not Affected By Helicobacter Pylori Infection in Children. Br J Nutr. 2017;118(4):273-279. PubMed PMID: 28875866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children. AU - Herter-Aeberli,Isabelle, AU - Eliancy,Kerline, AU - Rathon,Yanick, AU - Loechl,Cornelia U, AU - Marhône Pierre,Joseline, AU - Zimmermann,Michael B, PY - 2017/9/7/entrez PY - 2017/9/7/pubmed PY - 2017/9/20/medline KW - AGP α1-acid glycoprotein KW - BIS body Fe stores KW - CRP C-reactive protein KW - FeFum ferrous fumarate KW - SF serum ferritin KW - TfR transferrin receptor KW - Ferrous fumarate KW - Flour fortification KW - Iron absorption KW - Sodium iron EDTA SP - 273 EP - 279 JF - The British journal of nutrition JO - Br J Nutr VL - 118 IS - 4 N2 - Fe fortification of wheat flour was proposed in Haiti to combat Fe deficiency, but Fe bioavailability from fortificants has never been investigated in Haitian women or preschool children, two key target groups. We aimed to investigate the bioavailability of ferrous fumarate (FeFum), NaFeEDTA and their combination from fortified wheat flour. We recruited twenty-two healthy mother-child pairs in Port au Prince, Haiti, for an Fe-absorption study. We administered stable Fe isotopes as FeFum or NaFeEDTA individually in low-extraction wheat flour bread rolls consumed by all participants in a randomised, cross-over design. In a final, identical meal, consumed only by the women, FeFum+NaFeEDTA was administered. We measured Fe absorption by using erythrocyte incorporation of stable isotopes 14 d after consumption of each meal, and determined Fe status, inflammatory markers and Helicobacter pylori infection. Fe absorption (geometric mean was 9·24 (95 % CI 6·35, 13·44) and 9·26 (95 % CI 7·00, 12·31) from FeFum and 13·06 (95 % CI 9·23, 19·10) and 12·99 (95 % CI 9·18, 18·39) from NaFeEDTA in mothers and children, respectively (P<0·05 between compounds). Fe absorption from FeFum+NaFeEDTA was 11·09 (95 % CI 7·45, 17·34) and did not differ from the other two meals. H. pylori infection did not influence Fe absorption in children. In conclusion, in Haitian women and children, Fe absorption from NaFeEDTA was 40 % higher than from FeFum, and the combination FeFum+NaFeEDTA did not significantly increase Fe absorption compared with FeFum alone. In the context of Haiti, where the high costs of NaFeEDTA may not be affordable, the use of FeFum at 60 mg Fe/kg flour may be a preferable, cost-effective fortification strategy. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28875866/In_Haitian_women_and_preschool_children_iron_absorption_from_wheat_flour_based_meals_fortified_with_sodium_iron_EDTA_is_higher_than_that_from_meals_fortified_with_ferrous_fumarate_and_is_not_affected_by_Helicobacter_pylori_infection_in_children_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517002045/type/journal_article DB - PRIME DP - Unbound Medicine ER -