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A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort.

Abstract

Dietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases). Dietary intake was assessed at baseline using a quantitative FFQ and T2D status was based on three self-reports and confirmed by administrative data. Biomarkers were assessed about 10 years later in a biomarker subcohort (n 10 060). Sex- and ethnicity-specific hazard ratios were calculated for the Healthy Eating Index-2010 (HEI-2010), the alternative HEI-2010 (AHEI-2010), the alternate Mediterranean diet score (aMED) and the Dietary Approaches to Stop Hypertension (DASH). Multivariable-adjusted means of biomarkers were compared across dietary index tertiles in the biomarker subcohort. The AHEI-2010, aMED (in men only) and DASH scores were related to a 10-20 % lower T2D risk, with the strongest associations in whites and the direction of the relationships mostly consistent across ethnic groups. Higher scores on the four indices were related to lower HOMA-IR, TAG and C-reactive protein concentrations, not related to leptin, and the DASH score was directly associated with adiponectin. The AHEI-2010 and DASH were directly related to HDL-cholesterol in women. Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile.

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  • Authors+Show Affiliations

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    ,

    3Department of Preventive Medicine,Keck School of Medicine,Norris Comprehensive Cancer Center,University of Southern California,Los Angeles,CA,90032,USA.

    ,

    3Department of Preventive Medicine,Keck School of Medicine,Norris Comprehensive Cancer Center,University of Southern California,Los Angeles,CA,90032,USA.

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    ,

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    1Epidemiology Program,University of Hawaii Cancer Center,Honolulu,HI 96813,USA.

    Source

    The British journal of nutrition 118:4 2017 Aug pg 312-320

    MeSH

    Adiponectin
    African Americans
    Aged
    Asian Continental Ancestry Group
    C-Reactive Protein
    Cholesterol, HDL
    Cohort Studies
    Diabetes Mellitus, Type 2
    Diet
    Diet, Mediterranean
    Dyslipidemias
    Ethnic Groups
    European Continental Ancestry Group
    Female
    Hispanic Americans
    Humans
    Hypertension
    Inflammation
    Insulin Resistance
    Japan
    Male
    Middle Aged
    Oceanic Ancestry Group
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28875870

    Citation

    Jacobs, Simone, et al. "A Priori-defined Diet Quality Indices, Biomarkers and Risk for Type 2 Diabetes in Five Ethnic Groups: the Multiethnic Cohort." The British Journal of Nutrition, vol. 118, no. 4, 2017, pp. 312-320.
    Jacobs S, Boushey CJ, Franke AA, et al. A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort. Br J Nutr. 2017;118(4):312-320.
    Jacobs, S., Boushey, C. J., Franke, A. A., Shvetsov, Y. B., Monroe, K. R., Haiman, C. A., ... Maskarinec, G. (2017). A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort. The British Journal of Nutrition, 118(4), pp. 312-320. doi:10.1017/S0007114517002033.
    Jacobs S, et al. A Priori-defined Diet Quality Indices, Biomarkers and Risk for Type 2 Diabetes in Five Ethnic Groups: the Multiethnic Cohort. Br J Nutr. 2017;118(4):312-320. PubMed PMID: 28875870.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort. AU - Jacobs,Simone, AU - Boushey,Carol J, AU - Franke,Adrian A, AU - Shvetsov,Yurii B, AU - Monroe,Kristine R, AU - Haiman,Christopher A, AU - Kolonel,Laurence N, AU - Le Marchand,Loic, AU - Maskarinec,Gertraud, PY - 2017/9/7/entrez PY - 2017/9/7/pubmed PY - 2017/9/20/medline KW - A priori dietary indices KW - AHEI Alternative Healthy Eating Index KW - CRP C-reactive protein KW - DASH Dietary Approaches to Stop Hypertension KW - HEI Healthy Eating Index KW - HOMA-IR homoeostatic model assessment-estimated insulin resistance KW - MEC Multiethnic Cohort KW - QFFQ quantitative FFQ KW - T tertile KW - T2D type 2 diabetes KW - aMED alternate Mediterranean diet score KW - Adipokines KW - C-reactive protein KW - Dyslipidaemia KW - Ethnicity KW - Prospective cohorts KW - Type 2 diabetes SP - 312 EP - 320 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 118 IS - 4 N2 - Dietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases). Dietary intake was assessed at baseline using a quantitative FFQ and T2D status was based on three self-reports and confirmed by administrative data. Biomarkers were assessed about 10 years later in a biomarker subcohort (n 10 060). Sex- and ethnicity-specific hazard ratios were calculated for the Healthy Eating Index-2010 (HEI-2010), the alternative HEI-2010 (AHEI-2010), the alternate Mediterranean diet score (aMED) and the Dietary Approaches to Stop Hypertension (DASH). Multivariable-adjusted means of biomarkers were compared across dietary index tertiles in the biomarker subcohort. The AHEI-2010, aMED (in men only) and DASH scores were related to a 10-20 % lower T2D risk, with the strongest associations in whites and the direction of the relationships mostly consistent across ethnic groups. Higher scores on the four indices were related to lower HOMA-IR, TAG and C-reactive protein concentrations, not related to leptin, and the DASH score was directly associated with adiponectin. The AHEI-2010 and DASH were directly related to HDL-cholesterol in women. Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28875870/A_priori_defined_diet_quality_indices_biomarkers_and_risk_for_type_2_diabetes_in_five_ethnic_groups:_the_Multiethnic_Cohort_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517002033/type/journal_article DB - PRIME DP - Unbound Medicine ER -