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Severe neurotoxicity requiring mechanical ventilation in a dog envenomed by a red-bellied black snake (Pseudechis porphyriacus) and successful treatment with an experimental bivalent whole equine IgG antivenom.
Toxicon 2017; 138:159-164T

Abstract

Snakebite in dogs from Pseudechis porphyriacus (red-bellied black snake; RBBS) is a common envenomation treated by veterinarians in Australia where this snake occurs. This case report describes the successful treatment of a clinically severe RBBS envenomation in a dog with an experimental bivalent equine whole IgG antivenom and mechanical ventilation, following its presentation in a cyanotic state. The cause of the cyanosis and respiratory distress was considered due to paralysis from neurotoxins in RBBS venom. The dog was treated with two vials of bivalent antivenom, each containing sufficient antivenom to neutralise the lethal effects of 40 mg of tiger snake (Notechis sp) and 40 mg of brown snake (Pseudonaja sp) venom. Hypoxaemia (Sp02 of 75%) and hypercapnia (PaCO2 of 61 mmHg) indicated the need for mechanical ventilation (MV) to prevent imminent death. The dog was anaesthetised using total intravenous anaesthesia and MV used for 18 h. Following discontinuation of MV, it resumed spontaneous breathing thereafter and made a complete recovery. Serum biochemistry revealed a significant myopathy with elevated CK and AST levels, peaking approximately 48 h post-treatment. Elevated liver enzymes, suggestive of hypoxic liver injury, were detected during the period of hospitalisation. The dog represented approximately one week after hospital discharge because of inappetence and mild hepatopathy, which resolved spontaneously by 30 d post-treatment. A mild coagulopathy was initially present which resolved within 24 h following antivenom treatment. At initial presentation, RBBS venom antigen was detected by sandwich ELISA in urine and serum. Free RBBS venom antigen was not detected post-antivenom treatment. Human cases of RBBS requiring ventilatory support are rare. This unusual case of RBBS envenomation in a dog highlights its potential clinical severity in dogs, and the need for early, aggressive, MV to achieve a successful outcome in cyanosed and clinically severe cases.

Authors+Show Affiliations

Australian Venom Research Unit, Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 3010, Australia. Electronic address: andrew.padula@unimelb.edu.au.Veterinary Specialist Services and Animal Emergency Service, Underwood, Queensland, 4119, Australia.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28877511

Citation

Padula, A M., and E M. Leister. "Severe Neurotoxicity Requiring Mechanical Ventilation in a Dog Envenomed By a Red-bellied Black Snake (Pseudechis Porphyriacus) and Successful Treatment With an Experimental Bivalent Whole Equine IgG Antivenom." Toxicon : Official Journal of the International Society On Toxinology, vol. 138, 2017, pp. 159-164.
Padula AM, Leister EM. Severe neurotoxicity requiring mechanical ventilation in a dog envenomed by a red-bellied black snake (Pseudechis porphyriacus) and successful treatment with an experimental bivalent whole equine IgG antivenom. Toxicon. 2017;138:159-164.
Padula, A. M., & Leister, E. M. (2017). Severe neurotoxicity requiring mechanical ventilation in a dog envenomed by a red-bellied black snake (Pseudechis porphyriacus) and successful treatment with an experimental bivalent whole equine IgG antivenom. Toxicon : Official Journal of the International Society On Toxinology, 138, pp. 159-164. doi:10.1016/j.toxicon.2017.09.001.
Padula AM, Leister EM. Severe Neurotoxicity Requiring Mechanical Ventilation in a Dog Envenomed By a Red-bellied Black Snake (Pseudechis Porphyriacus) and Successful Treatment With an Experimental Bivalent Whole Equine IgG Antivenom. Toxicon. 2017;138:159-164. PubMed PMID: 28877511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe neurotoxicity requiring mechanical ventilation in a dog envenomed by a red-bellied black snake (Pseudechis porphyriacus) and successful treatment with an experimental bivalent whole equine IgG antivenom. AU - Padula,A M, AU - Leister,E M, Y1 - 2017/09/04/ PY - 2017/08/07/received PY - 2017/08/31/revised PY - 2017/09/01/accepted PY - 2017/9/7/pubmed PY - 2019/1/10/medline PY - 2017/9/7/entrez KW - Dog KW - Enzyme immunoassay KW - Pseudechis porphyriacus KW - Red-bellied black snake KW - Snake antivenom KW - Snake venom KW - Snakebite KW - Veterinary SP - 159 EP - 164 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 138 N2 - Snakebite in dogs from Pseudechis porphyriacus (red-bellied black snake; RBBS) is a common envenomation treated by veterinarians in Australia where this snake occurs. This case report describes the successful treatment of a clinically severe RBBS envenomation in a dog with an experimental bivalent equine whole IgG antivenom and mechanical ventilation, following its presentation in a cyanotic state. The cause of the cyanosis and respiratory distress was considered due to paralysis from neurotoxins in RBBS venom. The dog was treated with two vials of bivalent antivenom, each containing sufficient antivenom to neutralise the lethal effects of 40 mg of tiger snake (Notechis sp) and 40 mg of brown snake (Pseudonaja sp) venom. Hypoxaemia (Sp02 of 75%) and hypercapnia (PaCO2 of 61 mmHg) indicated the need for mechanical ventilation (MV) to prevent imminent death. The dog was anaesthetised using total intravenous anaesthesia and MV used for 18 h. Following discontinuation of MV, it resumed spontaneous breathing thereafter and made a complete recovery. Serum biochemistry revealed a significant myopathy with elevated CK and AST levels, peaking approximately 48 h post-treatment. Elevated liver enzymes, suggestive of hypoxic liver injury, were detected during the period of hospitalisation. The dog represented approximately one week after hospital discharge because of inappetence and mild hepatopathy, which resolved spontaneously by 30 d post-treatment. A mild coagulopathy was initially present which resolved within 24 h following antivenom treatment. At initial presentation, RBBS venom antigen was detected by sandwich ELISA in urine and serum. Free RBBS venom antigen was not detected post-antivenom treatment. Human cases of RBBS requiring ventilatory support are rare. This unusual case of RBBS envenomation in a dog highlights its potential clinical severity in dogs, and the need for early, aggressive, MV to achieve a successful outcome in cyanosed and clinically severe cases. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/28877511/Severe_neurotoxicity_requiring_mechanical_ventilation_in_a_dog_envenomed_by_a_red_bellied_black_snake__Pseudechis_porphyriacus__and_successful_treatment_with_an_experimental_bivalent_whole_equine_IgG_antivenom_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(17)30274-X DB - PRIME DP - Unbound Medicine ER -