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Ethical Issues Regarding CRISPR Mediated Genome Editing.
Curr Issues Mol Biol. 2018; 26:103-110.CI

Abstract

CRISPR-Cas9 has emerged as a simple, precise and most rapid genome editing technology. With a number of promising applications ranging from agriculture and environment to clinical therapeutics, it is greatly transforming the field of molecular biology. However, there are certain ethical, moral and safety concerns related to the attractive applications of this technique. The most contentious issues concerning human germline modifications are the challenges to human safety and morality such as risk of unforeseen, undesirable effects in clinical applications particularly to correct or prevent genetic diseases, matter of informed consent and the risk of exploitation for eugenics. Stringent regulations and guidelines as well as worldwide debate and awareness are required to ensure responsible and wise use of CRISPR mediated genome editing technology. There is a need for an extensive dialogue among scientists, ethicists, industrialists and policy makers on its societal implications. The opinion of different elements of the society including the general public as well as religious scholars is also critical. In countries with existing legislative framework, it might be appropriate to allow CRISPR based research to proceed with proper justification. However, much anticipated future clinical applications must be strictly regulated with newly established regulations.

Authors+Show Affiliations

Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan, and Pakistan Academy of Sciences, Islamabad, Pakistan.Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28879860

Citation

Shinwari, Zabta Khan, et al. "Ethical Issues Regarding CRISPR Mediated Genome Editing." Current Issues in Molecular Biology, vol. 26, 2018, pp. 103-110.
Shinwari ZK, Tanveer F, Khalil AT. Ethical Issues Regarding CRISPR Mediated Genome Editing. Curr Issues Mol Biol. 2018;26:103-110.
Shinwari, Z. K., Tanveer, F., & Khalil, A. T. (2018). Ethical Issues Regarding CRISPR Mediated Genome Editing. Current Issues in Molecular Biology, 26, 103-110. https://doi.org/10.21775/cimb.026.103
Shinwari ZK, Tanveer F, Khalil AT. Ethical Issues Regarding CRISPR Mediated Genome Editing. Curr Issues Mol Biol. 2018;26:103-110. PubMed PMID: 28879860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethical Issues Regarding CRISPR Mediated Genome Editing. AU - Shinwari,Zabta Khan, AU - Tanveer,Faouzia, AU - Khalil,Ali Talha, Y1 - 2017/09/07/ PY - 2017/9/8/pubmed PY - 2018/8/9/medline PY - 2017/9/8/entrez SP - 103 EP - 110 JF - Current issues in molecular biology JO - Curr Issues Mol Biol VL - 26 N2 - CRISPR-Cas9 has emerged as a simple, precise and most rapid genome editing technology. With a number of promising applications ranging from agriculture and environment to clinical therapeutics, it is greatly transforming the field of molecular biology. However, there are certain ethical, moral and safety concerns related to the attractive applications of this technique. The most contentious issues concerning human germline modifications are the challenges to human safety and morality such as risk of unforeseen, undesirable effects in clinical applications particularly to correct or prevent genetic diseases, matter of informed consent and the risk of exploitation for eugenics. Stringent regulations and guidelines as well as worldwide debate and awareness are required to ensure responsible and wise use of CRISPR mediated genome editing technology. There is a need for an extensive dialogue among scientists, ethicists, industrialists and policy makers on its societal implications. The opinion of different elements of the society including the general public as well as religious scholars is also critical. In countries with existing legislative framework, it might be appropriate to allow CRISPR based research to proceed with proper justification. However, much anticipated future clinical applications must be strictly regulated with newly established regulations. SN - 1467-3045 UR - https://www.unboundmedicine.com/medline/citation/28879860/Ethical_Issues_Regarding_CRISPR_Mediated_Genome_Editing_ L2 - https://www.caister.com/cimb/vb/v26/103.pdf DB - PRIME DP - Unbound Medicine ER -