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Clinical features and radiological findings of 67 patients with SAPHO syndrome.
Mod Rheumatol 2018; 28(4):703-708MR

Abstract

OBJECTIVES

The purpose of this study was to facilitate the understanding of the SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) syndrome by analyzing the clinical and radiological features of 67 Japanese patients with SAPHO syndrome.

METHODS

Sixty-seven Japanese patients (female/male: 44/23, mean age at onset: 48.5 years) were diagnosed with SAPHO syndrome from 2002 to 2013 at our hospital. Medical records and radiological imaging of these patients were retrospectively reviewed.

RESULTS

Among the 67 patients, 41 had dermatological manifestations, such as palmoplantar pustulosis, acne, and psoriasis. Initial symptom was local pain in all patients, and the most common initial site of the symptom was the anterior chest. Bacterial and fungal cultures from 20 bone biopsies were all negative. Histopathological diagnosis of the specimens was non-specific inflammation in all cases. Bone lesions were observed in 65 patients (97.0%). On the other hand, articular lesions including enthesitis were found in 31 patients (46.2%).

CONCLUSION

SAPHO syndrome had different clinical and radiological aspects. The clinical features were not remarkable, except the dermatological manifestations and the involvement of the anterior chest. Bone lesions including hyperostosis and osteitis were found radiographically in the majority of patients with SAPHO syndrome. These are the characteristics of the SAPHO syndrome, with the exclusion of other bone diseases.

Authors+Show Affiliations

a Department of Orthopaedic Surgery , Tohoku Rosai Hospital , Sendai , Japan. b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.c Department of Diagnostic Radiology , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.d Department of Pathology , Tohoku University Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.e Department of Orthopaedic Surgery , Tohoku Kosai Hospital , Sendai , Japan.b Department of Orthopaedic Surgery , Tohoku University Hospital , Sendai , Japan.a Department of Orthopaedic Surgery , Tohoku Rosai Hospital , Sendai , Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28880693

Citation

Okuno, Hiroshi, et al. "Clinical Features and Radiological Findings of 67 Patients With SAPHO Syndrome." Modern Rheumatology, vol. 28, no. 4, 2018, pp. 703-708.
Okuno H, Watanuki M, Kuwahara Y, et al. Clinical features and radiological findings of 67 patients with SAPHO syndrome. Mod Rheumatol. 2018;28(4):703-708.
Okuno, H., Watanuki, M., Kuwahara, Y., Sekiguchi, A., Mori, Y., Hitachi, S., ... Sato, K. (2018). Clinical features and radiological findings of 67 patients with SAPHO syndrome. Modern Rheumatology, 28(4), pp. 703-708. doi:10.1080/14397595.2017.1372874.
Okuno H, et al. Clinical Features and Radiological Findings of 67 Patients With SAPHO Syndrome. Mod Rheumatol. 2018;28(4):703-708. PubMed PMID: 28880693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features and radiological findings of 67 patients with SAPHO syndrome. AU - Okuno,Hiroshi, AU - Watanuki,Munenori, AU - Kuwahara,Yoshiyuki, AU - Sekiguchi,Akira, AU - Mori,Yu, AU - Hitachi,Shin, AU - Miura,Keiki, AU - Ogura,Ken, AU - Watanabe,Mika, AU - Hosaka,Masami, AU - Hatori,Masahito, AU - Itoi,Eiji, AU - Sato,Katsumi, Y1 - 2017/09/21/ PY - 2017/9/8/pubmed PY - 2018/10/12/medline PY - 2017/9/8/entrez KW - SAPHO syndrome KW - enthesitis KW - hyperostosis KW - osteitis KW - synovitis SP - 703 EP - 708 JF - Modern rheumatology JO - Mod Rheumatol VL - 28 IS - 4 N2 - OBJECTIVES: The purpose of this study was to facilitate the understanding of the SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) syndrome by analyzing the clinical and radiological features of 67 Japanese patients with SAPHO syndrome. METHODS: Sixty-seven Japanese patients (female/male: 44/23, mean age at onset: 48.5 years) were diagnosed with SAPHO syndrome from 2002 to 2013 at our hospital. Medical records and radiological imaging of these patients were retrospectively reviewed. RESULTS: Among the 67 patients, 41 had dermatological manifestations, such as palmoplantar pustulosis, acne, and psoriasis. Initial symptom was local pain in all patients, and the most common initial site of the symptom was the anterior chest. Bacterial and fungal cultures from 20 bone biopsies were all negative. Histopathological diagnosis of the specimens was non-specific inflammation in all cases. Bone lesions were observed in 65 patients (97.0%). On the other hand, articular lesions including enthesitis were found in 31 patients (46.2%). CONCLUSION: SAPHO syndrome had different clinical and radiological aspects. The clinical features were not remarkable, except the dermatological manifestations and the involvement of the anterior chest. Bone lesions including hyperostosis and osteitis were found radiographically in the majority of patients with SAPHO syndrome. These are the characteristics of the SAPHO syndrome, with the exclusion of other bone diseases. SN - 1439-7609 UR - https://www.unboundmedicine.com/medline/citation/28880693/Clinical_features_and_radiological_findings_of_67_patients_with_SAPHO_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/14397595.2017.1372874 DB - PRIME DP - Unbound Medicine ER -